Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Martin F Jarrold"'
Autor:
Chao Chen, Joseph Che-Yen Wang, Elizabeth E Pierson, David Z Keifer, Mildred Delaleau, Lara Gallucci, Christian Cazenave, Michael Kann, Martin F Jarrold, Adam Zlotnick
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005802 (2016)
Hepatitis B virus (HBV) capsids are found in many forms: immature single-stranded RNA-filled cores, single-stranded DNA-filled replication intermediates, mature cores with relaxed circular double-stranded DNA, and empty capsids. A capsid, the protein
Externí odkaz:
https://doaj.org/article/6da743e70a024966bb67ca76e98bcc91
Autor:
Junping Zhang, Dylan A. Frabutt, Matthew Chrzanowski, Ning Li, Lohra M. Miller, Jiahe Tian, Patrick L. Mulcrone, Anh K. Lam, Benjamin E. Draper, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101206- (2024)
Self-complementary AAV vectors (scAAV) use a mutant inverted terminal repeat (mITR) for efficient packaging of complementary stranded DNA, enabling rapid transgene expression. However, inefficient resolution at the mITR leads to the packaging of mono
Externí odkaz:
https://doaj.org/article/ba0fb73ec32b4ab08090643c484cf170
Autor:
Bryan Troxell, Sarah L. Jaslow, I-Wei Tsai, Chelsea Sullivan, Benjamin E. Draper, Martin F. Jarrold, Kate Lindsey, Levi Blue
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 288-302 (2023)
Recombinant adeno-associated viruses (rAAVs) deliver DNA to numerous cell types. However, packaging of partial genomes into the rAAV capsid is of concern. Although empty rAAV capsids are studied, there is little information regarding the impact of pa
Externí odkaz:
https://doaj.org/article/8a4925de91024196b5902ddf22890b66
Autor:
Xin Li, Lohra Mickelle Miller, Matthew Chrzanowski, Jiahe Tian, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao, Benjamin Draper, Junping Zhang
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Genetic engineering advances have led to recombinant adeno-associated virus (rAAV) becoming an invaluable tool for the development of effective gene therapies. The production of rAAV is susceptible to off-target heterogeneous packaging, the effects o
Externí odkaz:
https://doaj.org/article/b644a5a27ba2402b86be15f164c43ac0
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 327-336 (2022)
Charge detection mass spectrometry (CDMS) was used to analyze recombinant adeno-associated virus serotype 8 (rAAV8) vectors after incubation at elevated temperatures. rAAV8 vectors with a range of genomes of interest (GOIs) from 2.22 to 4.84 kb were
Externí odkaz:
https://doaj.org/article/3c212eaa5b8041f5a4fd01b527ebcdb2
Autor:
Lucas W. Henderson, Edie M. Sharon, Amit K. S. Gautam, Adam J. Anthony, Martin F. Jarrold, David H. Russell, Andreas Matouschek, David E. Clemmer
Publikováno v:
The Journal of Physical Chemistry Letters. :5014-5017
Autor:
Brianna M. Woodbury, Tina Motwani, Makayla N. Leroux, Lauren F. Barnes, Nicholas A. Lyktey, Sanchari Banerjee, Corynne L. Dedeo, Martin F. Jarrold, Carolyn M. Teschke
Publikováno v:
Viruses, Vol 14, Iss 7, p 1400 (2022)
The oligomerization and incorporation of the bacteriophage P22 portal protein complex into procapsids (PCs) depends upon an interaction with scaffolding protein, but the region of the portal protein that interacts with scaffolding protein has not bee
Externí odkaz:
https://doaj.org/article/e9045634e7dd4872a8e106b9a7a8c50f
Autor:
Lohra M. Miller, Martin F. Jarrold
Publikováno v:
Essays in Biochemistry. 67:315-323
Heterogeneity usually restricts conventional mass spectrometry to molecular weights less than around a megadalton. As a single-particle technique, charge detection mass spectrometry (CDMS) overcomes this limitation. In CDMS, the mass-to-charge (m/z)
Autor:
Lauren F. Barnes, Benjamin E. Draper, Justin Kurian, Yu-Ting Chen, Tatiana Shapkina, Thomas W. Powers, Martin F. Jarrold
Publikováno v:
Analytical Chemistry. 95:4310-4316
Autor:
Martin F. Jarrold
Publikováno v:
LCGC North America. :14-18
Conventional mass spectrometry is limited by heterogeneity to relatively small molecular weights from a biologics perspective. Charge detection mass spectrometry—where masses of individual ions are directly measured—overcomes this limitation and