Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Martin Ezechiáš"'
Autor:
Martin Ezechiáš
Publikováno v:
Toxicology Letters. 350:22-29
Concentration addition as a classic null model for toxicology and pharmacology is based on Loewe's mathematical formulation and the linearity of the isoboles. Novel mathematical models, however, propose curved isoboles in certain conditions. This art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288c2d41640b39fd29a1ca83c3bb9e71
https://doi.org/10.1016/j.toxlet.2021.06.016
https://doi.org/10.1016/j.toxlet.2021.06.016
Publikováno v:
Journal of hazardous materials. 423
Mixture toxicity, including agonistic and antagonistic effects, is an unrevealed environmental problem. Estrogenic endocrine disruptors are known to cause adverse effects for aquatic biota, but causative chemicals and their contributions to the total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253c630cb7958e06bf66fe4a1c1ab348
https://pubmed.ncbi.nlm.nih.gov/34523467
https://pubmed.ncbi.nlm.nih.gov/34523467
Autor:
Martin Ezechiáš
Publikováno v:
Environmental Toxicology and Pharmacology. 89:103781
Cell-based bioassays are very sensitive and allow integrative effect screening of the whole environmental sample, which is usually composed of a mixture of agonists and antagonists. Measured toxicity is usually expressed as a bioanalytical equivalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0574b4b46e1344c509ab8707c1258c8
https://doi.org/10.1016/j.etap.2021.103781
https://doi.org/10.1016/j.etap.2021.103781
Autor:
Tomáš Cajthaml, Martin Ezechiáš
Publikováno v:
Toxicology. 393:26-33
Living organisms interact with various chemical compounds via receptors, which is described by the receptor theory. The affinity of the biologically active compounds toward receptors and their ability to trigger a biological or toxic signal vary subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ae934dfa4d0c70001fa05ec8158f94
https://doi.org/10.1016/j.tox.2017.10.012
https://doi.org/10.1016/j.tox.2017.10.012
Autor:
Martin Ezechiáš, Tomáš Cajthaml
Publikováno v:
Toxicology. 420
The equilibrium dissociation constant of competitive antagonists represents the affinity of the receptor-ligand interaction, and it is a key characteristic of many therapeutic drugs or toxic compounds. Two commonly used methods by which the affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821453cedc823695dde01f9bb4e3e577
https://pubmed.ncbi.nlm.nih.gov/30935971
https://pubmed.ncbi.nlm.nih.gov/30935971
Autor:
Martin Ezechiáš, Tomáš Cajthaml
Publikováno v:
Toxicology. :58-70
Estrogenic compounds as well as other biologically active substances are commonly present in the form of complex mixtures in the environment. There is still no satisfactory model that would be capable of predicting the toxic effects of mixtures conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdecf039b7905ae02e2efba4122c691
https://doi.org/10.1016/j.tox.2016.06.017
https://doi.org/10.1016/j.tox.2016.06.017
Autor:
Martin Ezechiáš, Tomáš Cajthaml
Publikováno v:
Toxicology.
Receptor ligands in mixtures may produce effects that are greater than the effect predicted from their individual dose-response curves. The historical basis for predicting the mixture effect is based on Loewe’s concept and its mathematical formulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d0eb5ec023604a1311155f354d00c9
https://pubmed.ncbi.nlm.nih.gov/29660376
https://pubmed.ncbi.nlm.nih.gov/29660376
Autor:
Alena Filipová, Lucie Linhartová, Zdena Křesinová, Martin Ezechiáš, Tomáš Cajthaml, Pavel Mašín
Publikováno v:
New biotechnology. 43
The white rot fungus Pleurotus ostreatus HK 35, which is also an edible industrial mushroom commonly cultivated in farms, was tested in the degradation of typical representatives of endocrine disrupters (EDCs; bisphenol A, estrone, 17β-estradiol, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5423405ca6e2b0983f8bc916be79d221
https://pubmed.ncbi.nlm.nih.gov/28502780
https://pubmed.ncbi.nlm.nih.gov/28502780
Publikováno v:
Chemosphere. 152
A considerable amount of scientific evidence indicates that a number of pharmaceuticals that could be detected in the environment can contribute towards the development of problems associated with human reproductive systems, as well as those of wildl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2a05e3506cb010d93d0316100fa081
https://pubmed.ncbi.nlm.nih.gov/26978704
https://pubmed.ncbi.nlm.nih.gov/26978704
Publikováno v:
Environmental Science & Technology. 46:13377-13385
The white rot fungus Pleurotus ostreatus is able to completely remove the synthetic hormone 17α-ethinylestradiol (EE2, 200 μg in 20 mL) from a liquid complex or mineral medium in 3 or 14 days, respectively. Its efficiency has also been documented i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa9b0a21c08a9a58c505be1ff870306
https://doi.org/10.1021/es3029507
https://doi.org/10.1021/es3029507