Výsledky vyhledávání - "Martin Enrique Garaycoechea"

Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease

Autor: Silvia Cristina Sookoian, Diego Martin Flichman, Carlos José Pirola, Gustavo Osvaldo Castaño, Martin Enrique Garaycoechea

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background and aims: The progression of nonalcoholic fatty liver disease (NAFLD) into severe histological forms (steatohepatitis – NASH) is paralleled by the occurrence of complex molecular processes. Mitochondrial dysfunction is a hallmark feature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32198842e929824e0af071949354fd0
https://doi.org/10.1111/joim.13147

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Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

Autor: Martin Enrique Garaycoechea, Carlos José Pirola, Adrián Emanuel Salatino, Gustavo Osvaldo Castaño, Cinthia Belen Fijalkowky, Silvia Cristina Sookoian, Maria Silvina Landa

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Objective: We aimed to characterise the liver tissue bacterial metataxonomic signature in two independent cohorts of patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) diagnosis, as differences in the host phenotypic features - fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae3ec8d4c83c42b8a57f60f6b9836bb
https://doi.org/10.1136/gutjnl-2019-318811

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Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease[S]

Autor: Martin Enrique Garaycoechea, Silvia Cristina Sookoian, Carlos José Pirola, Diego Martin Flichman, Gustavo Osvaldo Castaño, Julio San Martino, Marco Arrese, Carla Gazzi

Publikováno v: Journal of Lipid Research, Vol 60, Iss 1, Pp 176-185 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) is a lipid droplet-associated protein; its gene-encoding variants affect the chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). To estimate the effect of rs72613567, a splice v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe90bc5b07dfd0ee905c76272c9ba061
http://www.sciencedirect.com/science/article/pii/S0022227520326754

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Lack of evidence supporting a role of TMC4-rs641738 missense variant - MBOAT7- intergenic downstream variant - In the Susceptibility to Nonalcoholic Fatty Liver Disease

Autor: Gustavo Osvaldo Castaño, Carlos José Pirola, Silvia Cristina Sookoian, Julio San Martino, Martin Enrique Garaycoechea, Diego Martin Flichman, Carla Gazzi

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Current knowledge on the genetic basis of nonalcoholic fatty liver disease (NAFLD) suggests that variants contributing not only to the disease predisposition but histological severity as well are located in genes that regulate lipid metabolism. We ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5530baa2aaf9fe909513a2a32f60174
http://www.nature.com/articles/s41598-018-23453-9

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Metastasis-associated lung adenocarcinoma transcript 1 as a common molecular driver in the pathogenesis of nonalcoholic steatohepatitis and chronic immune-mediated liver damage

Autor: Silvia Cristina Sookoian, Martin Enrique Garaycoechea, Carlos José Pirola, Julio San Martino, Gustavo Osvaldo Castaño, Diego Martin Flichman

Publikováno v: Hepatology Communications
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Long noncoding RNAs (lncRNAs) are functional molecules that orchestrate gene expression. To identify lncRNAs involved in nonalcoholic fatty liver disease (NAFLD) severity, we performed a multiscale study that included: (a) systems biology modeling th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004e1b7e540159c98464cd0a57777ba
Wiley Online Library

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A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis

Autor: Cristian Oscar Rohr, Martin Enrique Garaycoechea, Hernán Dopazo, Tomás Fernández Gianotti, Carlos José Pirola, Julio San Martino, Gustavo Osvaldo Castaño, Carla Gazzi, Diego Martin Flichman, Silvia Cristina Sookoian

Publikováno v: Hepatology Communications
Hepatology Communications, Vol 2, Iss 9, Pp 1030-1036 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

We report on the presence of a rare nonsense mutation (rs149847328, p.Arg227Ter) in the glucokinase regulator (GCKR) gene in an adult patient with nonalcoholic fatty liver disease (NAFLD), morbid obesity, and type 2 diabetes; this patient developed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07afcd1436539e22cec566851463d0e5
https://pubmed.ncbi.nlm.nih.gov/30202818

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