Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Martin Eilers"'
Autor:
Abdallah Gaballa, Anneli Gebhardt-Wolf, Bastian Krenz, Greta Mattavelli, Mara John, Giacomo Cossa, Silvia Andreani, Christina Schülein-Völk, Francisco Montesinos, Raphael Vidal, Carolin Kastner, Carsten P. Ade, Burkhard Kneitz, Georg Gasteiger, Peter Gallant, Mathias Rosenfeldt, Angela Riedel, Martin Eilers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation compl
Externí odkaz:
https://doaj.org/article/8a9d10af203b42eb8a6cbb3a3a12d74d
Autor:
Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dosSantos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp n/a-n/a (2023)
Abstract Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens
Externí odkaz:
https://doaj.org/article/f738f088a5b24d4d84df76ffa09916f9
Autor:
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly r
Externí odkaz:
https://doaj.org/article/07f7321be51a4bf993332239abb08b2b
Autor:
Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering
Publikováno v:
Molecular Oncology, Vol 16, Iss 15, Pp 2788-2809 (2022)
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli
Externí odkaz:
https://doaj.org/article/86ca5923c6f34dcb85b7467dac7cbb83
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101183- (2022)
Summary: Here, we detail a protocol for the generation of pooled short hairpin RNA (shRNA) libraries. We cover the design of optimized miR-E backbone shRNAs, cloning into a Tet-on vector system, and transformation of competent bacteria. We also descr
Externí odkaz:
https://doaj.org/article/3d9287dd87d943aeb49bac14b73896d4
Autor:
Michael Dietachmayr, Abirami Rathakrishnan, Oleksandra Karpiuk, Felix von Zweydorf, Thomas Engleitner, Vanesa Fernández-Sáiz, Petra Schenk, Marius Ueffing, Roland Rad, Martin Eilers, Christian Johannes Gloeckner, Katharina Clemm von Hohenberg, Florian Bassermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X tha
Externí odkaz:
https://doaj.org/article/bd16efa5decb42a998a0892197a13545
Autor:
Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Elevated MYC levels can sensitize tumor cells to apoptosis. In this study, the authors demonstrate that AMPK activation and BCL-2/BCL-XL inhibition have a synergistic effect on apoptosis, and that together with anti PD-1 therapy they can suppress Myc
Externí odkaz:
https://doaj.org/article/d3f1f919795e44fe8702e5ba84a712b6
Autor:
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
Abstract The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase U
Externí odkaz:
https://doaj.org/article/1898fb6a9b9447fe970065bbeeb04bce
Autor:
Gabriele Büchel, Anne Carstensen, Ka-Yan Mak, Isabelle Roeschert, Eoin Leen, Olga Sumara, Julia Hofstetter, Steffi Herold, Jacqueline Kalb, Apoorva Baluapuri, Evon Poon, Colin Kwok, Louis Chesler, Hans Michael Maric, David S. Rickman, Elmar Wolf, Richard Bayliss, Susanne Walz, Martin Eilers
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3483-3497 (2017)
Summary: MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II). To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma
Externí odkaz:
https://doaj.org/article/09207f0506bb47e089f8a4b47d59ee99
Autor:
Stefanie Peter, Jennyfer Bultinck, Kevin Myant, Laura A Jaenicke, Susanne Walz, Judith Müller, Michael Gmachl, Matthias Treu, Guido Boehmelt, Carsten P Ade, Werner Schmitz, Armin Wiegering, Christoph Otto, Nikita Popov, Owen Sansom, Norbert Kraut, Martin Eilers
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1525-1541 (2014)
Abstract Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF‐BP1, MULE) associates with both MYC and the MYC‐associated protein MI
Externí odkaz:
https://doaj.org/article/285765620d5f424582909a71e1e55870