Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Martin E.M. Noble"'
Autor:
Stephen T. Hallett, Martyna W. Pastok, R. Marc L. Morgan, Anita Wittner, Katie L.I.M. Blundell, Ildiko Felletar, Stephen R. Wedge, Chrisostomos Prodromou, Martin E.M. Noble, Laurence H. Pearl, Jane A. Endicott
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1386-1398 (2017)
Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system. Like other Hsp90
Externí odkaz:
https://doaj.org/article/47f3367cf8e14eb7a9f180a5866f49b6
Autor:
Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, Mohammed J Al Yasiri
Publikováno v:
Journal of Medicinal Chemistry. 64:10001-10018
NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains
Autor:
Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
Publikováno v:
Journal of Medicinal Chemistry. 64:4071-4088
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibit
Autor:
Natalie J. Tatum, Megan A Cassidy, Pamela A. Lochhead, David Oxley, Julie A. Tucker, Victoria P Johnson, Andrew M. Kidger, Simon J. Cook, Martin E.M. Noble, Nathanael S. Gray, Jinhua Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The dual protein kinase-transcription factor, ERK5, is an emerging drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been developed. However, selective ERK5 kinase inhibitors fail to recapitulate ERK5 genetic abla
Autor:
Marcin Wojdyr, Paul D. Adams, David G. Brown, Zukang Feng, Yasuyo Ikegawa, Lora Mak, Minyu Chen, Billy K. Poon, John D. Westbrook, Ezra Peisach, Jasmine Young, Helen M. Berman, Masashi Yokochi, Nigel W. Moriarty, Yu-He Liang, Stephen K. Burley, John L. Markley, Garib N. Murshudov, John M. Berrisford, Eldon L. Ulrich, Sameer Velankar, Yumiko Kengaku, Aleksandras Gutmanas, Dorothee Liebschner, C. Flensburg, Pavel V. Afonine, Kumaran Baskaran, Clemens Vonrhein, Jeffrey C. Hoch, Eugene Krissinel, Irina Persikova, Genji Kurisu, Oleg V. Sobolev, Martin E.M. Noble, Gérard Bricogne
Publikováno v:
Acta crystallographica. Section D, Structural biology, vol 75, iss Pt 4
This letter announces that PDBx/mmCIF format files will become mandatory for crystallographic depositions to the Protein Data Bank (PDB).
Autor:
Ian R. Hardcastle, Celine Cano, Mathew P. Martin, Leanne E Knight, Michael J. Waring, Islam Al-Khawaldeh, J. Daniel Lopez-Fernandez, Miller Duncan Charles, Jane A. Endicott, Martin E.M. Noble, Shengying Lin, D.J. Wood, Conghao Gai
Publikováno v:
Journal of Medicinal Chemistry. 62:3741-3752
Identifying ligand binding sites on proteins is a critical step in target-based drug discovery. Current approaches to this require resource-intensive screening of large libraries of lead-like or fragment molecules. Here, we describe an efficient and
Autor:
Judith Reeks, James R. Ault, Martyna W. Pastok, Natalie J. Tatum, Svitlana Korolchuk, Mengxi Liu, Martin E.M. Noble, Richard A Heath, Frank Sobott, Bailey C. Montefiore, D.J. Wood, Lan-Zhen Wang, Michele Pagano, Jane A. Endicott, Marco Salamina, Arnaud Baslé, Stefan T. Arold
Publikováno v:
Journal of Molecular Biology
Graphical abstract
Highlights • SKP2 engages a site on the N-terminal lobe of cyclin A. • SKP2 recruits a catalytic CDK2-cyclin A to CDK2-cyclin A-CKS1-p27KIP1-SKP1-SKP2. • The SKP2 and p27KIP1 binding sites on cyclin A are divergent but o
Highlights • SKP2 engages a site on the N-terminal lobe of cyclin A. • SKP2 recruits a catalytic CDK2-cyclin A to CDK2-cyclin A-CKS1-p27KIP1-SKP1-SKP2. • The SKP2 and p27KIP1 binding sites on cyclin A are divergent but o
Autor:
Arnaud Baslé, Natalie J. Tatum, Frank Sobott, Stefan T. Arold, Marco Salamina, Bailey C. Montefiore, Richard A Heath, Martin E.M. Noble, Judith Reeks, D.J. Wood, Lan-Zhen Wang, Michele Pagano, Mengxi Liu, Svitlana Korolchuk, Jane A. Endicott, Martyna W. Pastok, James R. Ault
The SCFSKP2 ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1af534de89e8bab164434dd0bc2f1a
https://doi.org/10.1101/2020.10.08.329599
https://doi.org/10.1101/2020.10.08.329599
Autor:
Peter O'Brien, C. David Owen, Alice Douangamath, Louise Dunnett, Efrat Resnick, Mathew P. Martin, P. Gehrtz, R. Skyner, José Brandão-Neto, Nir London, Martin A. Walsh, Petra Lukacik, S. Paul Jones, Péter Ábrányi-Balogh, James D. Firth, M. Snee, Rambabu N. Reddi, Anna Carbery, D. Fearon, Aaron Keeley, Hanna F. Klein, T. Krojer, Gemma Davison, Frank von Delft, Conor Wild, Michael J. Waring, A.J. Powell, Martin E.M. Noble, G.M. Keseru, Claire Strain-Damerell, A. Aimon, Thomas D. Downes, Alexandre Dias, Michael Fairhead
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0901607193d626009824417763fb3128
https://doi.org/10.1101/2020.05.27.118117
https://doi.org/10.1101/2020.05.27.118117
Publikováno v:
Essays in Biochemistry. 61:439-452
The cell fate-determining roles played by members of the cyclin-dependent protein kinase (CDK) family explain why their dysregulation can promote proliferative diseases, and identify them as potential targets for drug discovery in oncology and beyond