Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Martin E. Seipel"'
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
The acquisition of apoptosis resistance is a fundamental event in cancer development. Among the mechanisms used by cancer cells to evade apoptosis is the dysregulation of inhibitor of apoptosis (IAP) proteins. The activity of the IAPs is regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749eac6e33c3d6ae4c15d5416ec41d41
https://doi.org/10.1158/1535-7163.c.6536442.v1
https://doi.org/10.1158/1535-7163.c.6536442.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
PDF file - 1384KB, Supplemental Figure 1. Structure of biotinylated birinapant Supplemental Figure 2. Concentration-dependent degradation of GFP-cIAP1/2 by birinapant Supplemental Figure 3. Representative examples of data analysis from 111 cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cfd31d3e0c71e37181fc6d9362974f
https://doi.org/10.1158/1535-7163.22500405.v1
https://doi.org/10.1158/1535-7163.22500405.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
PDF file - 73KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6017e6fd5bb940ccaf18ea18c0384148
https://doi.org/10.1158/1535-7163.22500408.v1
https://doi.org/10.1158/1535-7163.22500408.v1
Autor:
Srinivas K. Chunduru, Mark A. McKinlay, Yigong Shi, David Weng, Martin A. Graham, Matthew D. Alexander, Thomas Haimowitz, Yu-Hua Lee, Pavan K. Tirunahari, Mukta S. Hendi, Yijun Deng, Susan R. Rippin, Matthew G. LaPorte, Gurpreet S. Kapoor, Martin E. Seipel, Guangyao Yu, Stephen M. Condon, Eric M. Neiman, Jennifer M. Burns, Yasuhiro Mitsuuchi, Christopher A. Benetatos
XLS file - 45KB, Sensitivity of a 111 cell line panel to birinapant as a single agent and in combination with TNF or TRAIL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a5608cfd12aa98c693523b28ad5a19
https://doi.org/10.1158/1535-7163.22500402.v1
https://doi.org/10.1158/1535-7163.22500402.v1
Autor:
Stephen M. Condon, Pavan Tirunahari Kumar, Eric M. Neiman, Yijun Deng, Thomas Haimowitz, Bodhi Bettjeman, Yu Hua Lee, Xiaochun Li, Gurpreet S. Kapoor, Mukta S. Hendi, Rebecca Feltham, Martin E. Seipel, Christopher A. Benetatos, Jiawei Wang, Guangyao Yu, Catherine L. Day, James E Vince, Matthew D Alexander, Susan R. Rippin, Jennifer M. Burns, John Silke, Matthew G. LaPorte, Yasuhiro Mitsuuchi, Nufail Khan, Yigong Shi, Mark A. McKinlay, Mathew H. Cumming, Martin A. Graham, Srinivas K. Chunduru
Publikováno v:
Journal of medicinal chemistry. 57(9)
Birinapant (1) is a second-generation bivalent antagonist of IAP proteins that is currently undergoing clinical development for the treatment of cancer. Using a range of assays that evaluated cIAP1 stability and oligomeric state, we demonstrated that
Autor:
Christopher A. Benetatos, Martin E. Seipel, Pavan K. Tirunahari, Yu-Hua Lee, Thomas Haimowitz, Yijun Deng, Gurpreet S. Kapoor, Matthew D Alexander, Martin A. Graham, Srinivas K. Chunduru, Mukta S. Hendi, Eric M. Neiman, Jennifer M. Burns, Guangyao Yu, Stephen M. Condon, David E. Weng, Yasuhiro Mitsuuchi, Mark A. McKinlay, Susan R. Rippin, Matthew G. LaPorte, Yigong Shi
Publikováno v:
Molecular cancer therapeutics. 13(4)
The acquisition of apoptosis resistance is a fundamental event in cancer development. Among the mechanisms used by cancer cells to evade apoptosis is the dysregulation of inhibitor of apoptosis (IAP) proteins. The activity of the IAPs is regulated by
Autor:
C. Glenn Begley, Christopher A. Benetatos, Jennifer M. Burns, Angeline C. Mufalli, Gurpreet S. Kapoor, Yasuhiro Mitsuuchi, Martin E. Seipel, Yijun Deng, Thomas Haimowitz, Stephen M. Condon
Publikováno v:
Cancer Research. 74:1806-1806
The second mitochondria-derived activator of caspases (SMAC) is thought to exert its pro-apoptotic activity as a homodimeric protein. Both monovalent and bivalent peptidomimetics of the SMAC tetrapeptide are being developed for cancer therapy. Birina
Autor:
Christopher A. Benetatos, Guangyao Yu, Yasuhiro Mitsuuchi, Gurpreet S. Kapoor, Martin E. Seipel, Eric M. Neiman, Mark A. McKinlay, Stephen M. Condon, Srinivas K. Chunduru
Publikováno v:
Cancer Research. 73:5302-5302
Acquired resistance to cancer therapies remains a major therapeutic challenge. Identification of resistance mechanisms and biomarkers of acquired resistance are important for management of patients with drug refractory tumors. The present study was a
Autor:
Gurpreet S. Kapoor, Hans Minderman, Eric M. Neiman, Srinivas K. Chunduru, Martin E. Seipel, Stephen M. Condon, Guangyao Yu, Orla Maguire, David Weng, Yasuhiro Mitsuuchi, Christopher A. Benetatos, Angeline C. Mufalli, Martin C. Graham, Mark A. McKinlay
Publikováno v:
Cancer Research. 73:3333-3333
A variety of Smac-mimetic drugs have been developed to target the inhibitor of apoptosis (IAP) proteins including X chromosome-linked IAP (XIAP), cellular IAP proteins (cIAP1 and cIAP2) and ML-IAP whose gene mutations, amplifications and chromosomal
Autor:
Srinivas K. Chunduru, Stephen M. Condon, Yasuhiro Mitsuuchi, Gurpreet S. Kapoor, Christopher A. Benetatos, Mark A. McKinlay, Martin C. Graham, Jennifer M. Burns, Ernest C. Borden, Guangyao Yu, C. Glenn Begley, David Weng, Eric M. Neiman, Martin E. Seipel, Daniel J. Lindner
Publikováno v:
Cancer Research. 73:3336-3336
The Inhibitor of Apoptosis (IAP) protein family is able to inhibit cell death and promote survival signaling triggered by a wide variety of stimuli. Two members of this family in particular, cIAP1 and cIAP2, play key roles in enabling tumor necrosis