Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martin E. Hess"'
Autor:
Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E. Cieślak, Łukasz Szumiec, Martin E. Hess, Hella S. Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C. Brüning
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3182-3198.e9 (2019)
Summary: Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neur
Externí odkaz:
https://doaj.org/article/a536d8e99e444152a3de8a1661f87a00
Autor:
Martin E. Hess, Max Diesner, Hans-Joachim Pflüger, Joachim Schmidt, Estefania Delgado-Betancourt, Susanne Neupert, Thomas Stolz
Publikováno v:
Journal of Neurophysiology. 122:2388-2413
Neuromodulatory neurons located in the brain can influence activity in locomotor networks residing in the spinal cord or ventral nerve cords of invertebrates. How inputs to and outputs of neuromodulatory descending neurons affect walking activity is
Autor:
K Begemann, A Moser, L Griewahn, Jana-Thabea Kiehn, Henrik Oster, Jan Mauer, S M Schmid, Christiane E Koch, Martin E. Hess, Jens C. Brüning
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, f
Autor:
Katharina Timper, Heiko Backes, Philipp Hammerschmidt, Stephan Bremser, Thomas Benzing, Andreas Klein, Sophie M. Steculorum, Linda Engström Ruud, Peter Frommolt, Jens C. Brüning, Martin E. Hess, Johan Ruud, Jan Mauer, Donald A. Morgan, Paul Brinkkötter, Peter Kloppenburg, Ismene Karakasilioti, F. Thomas Wunderlich, Merly C. Vogt, Kamal Rahmouni, Eva Tsaousidou, Lars Paeger
Publikováno v:
Cell. 165(1):125-138
Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through
Autor:
Jens Alber, Johan Ruud, Jens C. Brüning, Hans Nissbrandt, Łukasz Szumiec, Hella S. Brönneke, Linda Engström Ruud, Anna Tokarska, Nasim Biglari, Jan Rodriguez Parkitna, Tatiana Korotkova, Änne Lautenschlager, Marcus Krüger, Gilad Silberberg, Hendrik Nolte, Przemysław Eligiusz Cieślak, Rachel N. Lippert, Martin E. Hess
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3182-3198.e9 (2019)
Summary: Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neur
Autor:
Marc Tittgemeyer, Markus Ullsperger, Klaas E. Stephan, Leonhard Schilbach, Anne B. Kühn, Theo O.J. Gruendler, Jan Mauer, Meltem Sevgi, Lionel Rigoux, Martin E. Hess, Jens C. Brüning
Publikováno v:
Journal of Neuroscience. 35:12584-12592
Variations in the fat mass and obesity-associated (FTO) gene are linked to obesity. However, the underlying neurobiological mechanisms by which these genetic variants influence obesity, behavior, and brain are unknown. Given that Fto regulates D2/3R
Autor:
Jens C. Brüning, Martin E. Hess
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842:2039-2047
Genome wide association studies undoubtedly linked variants of the fat mass and obesity-associated protein (FTO) to obesity. To date, however, knowledge on the mechanisms coupling variants in the intron of the FTO gene to its expression or enzymatic
Autor:
Jun, Zhou, Ji, Wan, Xin Erica, Shu, Yuanhui, Mao, Xiao-Min, Liu, Xin, Yuan, Xingqian, Zhang, Martin E, Hess, Jens C, Brüning, Shu-Bing, Qian
Publikováno v:
Molecular cell. 69(4)
The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or re
Autor:
Xingqian Zhang, Xin Yuan, Shu-Bing Qian, Xiao-Min Liu, Jun Zhou, Ji Wan, Yuanhui Mao, Jens C. Brüning, Martin E. Hess, Xin Erica Shu
Publikováno v:
Molecular Cell. 69:636-647.e7
The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or re
Autor:
Lutz W. Kracht, Jan Mauer, Marc Tittgemeyer, Delia-Lisa Feis, Leonhard Schilbach, Anne B. Kühn, Jens C. Brüning, Martin E. Hess
Publikováno v:
NeuroImage. 128
Variations in the fat mass and obesity associated (FTO) gene are currently the strongest known genetic factor predisposing humans to non-monogenic obesity. Recent experiments have linked these variants to a broad spectrum of behavioural alterations,