Biomarker candidates for the detection of an infectious etiology of febrile neutropenia

Autor: Michael Kiehntopf, Paul La Rosée, Tom Bretschneider, Christine Pausch, Frank M. Brunkhorst, Sophie Neugebauer, Martin E. A. Richter, Christoph Engel, Andreas Hochhaus, Herbert G. Sayer, Falco Engelmann, Stefan Hagel, Katrin Ludewig, Marie von Lilienfeld-Toal

Publikováno v: Infection. 44:175-186

Infections and subsequent septicemia are major complications in neutropenic patients with hematological malignancies. Here, we identify biomarker candidates for the early detection of an infectious origin, and monitoring of febrile neutropenia (FN).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d0948c26af29ddeb9d18af8807e8de
https://doi.org/10.1007/s15010-015-0830-6

Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step

Autor: Matthias Henrot, Martin E. A. Richter, Michaël De Paolis, Jacques Maddaluno, Christian Hertweck

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51 (38), pp.9587-9591. ⟨10.1002/anie.201204259⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9671eefd2355ffd1afed406a0311590
https://doi.org/10.1002/anie.201204259

Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts

Autor: Martin E. A. Richter, Ekkehard Hiller, Bernhard Hube, Lydia Kasper, Sascha Brunke, Dominique Ferrandon, Christophe d'Enfert, Jessica Quintin, Steffen Rupp, Karl Kuchler, Ilse D. Jacobsen, Tobias Schwarzmüller

Publikováno v: Disease Models & Mechanisms
Disease Models & Mechanisms, Cambridge Company of Biologists, 2015, 8 (5), pp.473-486. ⟨10.1242/dmm.019901⟩
Disease Models and Mechanisms 5 (8), 473-486. (2015)
Disease Models & Mechanisms, Vol 8, Iss 5, Pp 473-486 (2015)
Disease Models & Mechanisms, 2015, 8 (5), pp.473-486. ⟨10.1242/dmm.019901⟩

Studying infectious diseases requires suitable hosts for experimental in vivo infections. Recent years have seen the advent of many alternatives to murine infection models. However, the use of non-mammalian models is still controversial because it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ec6b2e629f1b37c9db7f13916ea47
https://pubmed.ncbi.nlm.nih.gov/25786415

Pyran Formation by an Atypical CYP-Mediated Four-Electron Oxygenation-Cyclization Cascade in an Engineered Aureothin Pathway

Autor: Benjamin Busch, Keishi Ishida, Bradley S. Moore, Martin E. A. Richter, Christian Hertweck

Small changes, big effect: A new aureothin derivative, aureopyran, which features an unusual pyran backbone, was generated by simply altering the enzymatic methylation topology. The α-pyrone ring hampers the correct placement of the polyketide backb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e95a096099fc078118169c55505fcc6
https://europepmc.org/articles/PMC3517090/

Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications

Autor: Martin E. A. Richter, Alokta Chakrabarti, Ivo R. Ruttekolk, Roland Brock, Jörg Rademann, Heike Glauner, Falk Duchardt, Wouter P. R. Verdurmen

Publikováno v: Molecular Pharmacology, 79, 692-700
Molecular Pharmacology, 79, 4, pp. 692-700

Item does not contain fulltext Here, we demonstrate that coupling to N-hydroxypropyl methacrylamide (HPMA) copolymer greatly enhances the activity of apoptosis-inducing peptides inside cells. Peptides corresponding to the BH3 domain of Bid were coupl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd258415c9a78a7e50ba47969e38350
https://pubmed.ncbi.nlm.nih.gov/21247935