Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Martin E Rottenberg"'
Autor:
Gabriela C Olivera, Leonie Vetter, Chiara Tesoriero, Federico Del Gallo, Gustav Hedberg, Juan Basile, Martin E Rottenberg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009764 (2021)
The infection by Trypanosoma brucei brucei (T.b.b.), a protozoan parasite, is characterized by an early-systemic stage followed by a late stage in which parasites invade the brain parenchyma in a T cell-dependent manner. Here we found that early afte
Externí odkaz:
https://doaj.org/article/d02266cd13464e0ba538fe5733379b97
Autor:
Lili Zou, Jun Lu, Jun Wang, Xiaoyuan Ren, Lanlan Zhang, Yu Gao, Martin E Rottenberg, Arne Holmgren
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1165-1178 (2017)
Abstract Multidrug‐resistant (MDR) Gram‐negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance. Here, we report that five most clinically difficu
Externí odkaz:
https://doaj.org/article/35cdb17ce96d4e5e90b30d0bb004aa34
Autor:
Yu Gao, Juan Ignacio Basile, Cajsa Classon, Dolores Gavier-Widen, Akihiko Yoshimura, Berit Carow, Martin E Rottenberg
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006809 (2018)
STAT3 is a master regulator of the immune responses. Here we show that M. tuberculosis-infected stat3fl/fl lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but highe
Externí odkaz:
https://doaj.org/article/124936c6589544bf8270865402460584
Autor:
Gabriela C Olivera, Xiaoyuan Ren, Suman K Vodnala, Jun Lu, Lucia Coppo, Chaniya Leepiyasakulchai, Arne Holmgren, Krister Kristensson, Martin E Rottenberg
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005442 (2016)
Nitric oxide (NO) generated by inducible NO synthase (iNOS) is critical for defense against intracellular pathogens but may mediate inflammatory tissue damage. To elucidate the role of iNOS in neuroinflammation, infections with encephalitogenic Trypa
Externí odkaz:
https://doaj.org/article/b5318e5e09424b96b896e0e77e60e8e8
Autor:
Berit Carow, Ann-Kathrin Reuschl, Dolores Gavier-Widén, Brendan J Jenkins, Matthias Ernst, Akihiko Yoshimura, Benedict J Chambers, Martin E Rottenberg
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003442 (2013)
Suppressor of cytokine signalling 3 (SOCS3) negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens. In the
Externí odkaz:
https://doaj.org/article/ccb20071a27346fea8f7fc0ef60e5438
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002464 (2012)
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis in
Externí odkaz:
https://doaj.org/article/b42546be93334f2eba6b168ff034b108
Autor:
Filip Claes, Suman K Vodnala, Nick van Reet, Nathalie Boucher, Hilda Lunden-Miguel, Theo Baltz, Bruno Maria Goddeeris, Philippe Büscher, Martin E Rottenberg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e486 (2009)
Monitoring Trypanosoma spread using real-time imaging in vivo provides a fast method to evaluate parasite distribution especially in immunoprivileged locations. Here, we generated monomorphic and pleomorphic recombinant Trypanosoma brucei expressing
Externí odkaz:
https://doaj.org/article/489ad5b85b6b402b85dff1c5de3057c4
Autor:
Suman K Vodnala, Marcela Ferella, Hilda Lundén-Miguel, Evans Betha, Nick van Reet, Daniel Ndem Amin, Bo Oberg, Björn Andersson, Krister Kristensson, Hans Wigzell, Martin E Rottenberg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 8, p e495 (2009)
BACKGROUND: There is an urgent need to substitute the highly toxic compounds still in use for treatment of the encephalitic stage of human African trypanosomiasis (HAT). We here assessed the treatment with the doublet cordycepin and the deaminase inh
Externí odkaz:
https://doaj.org/article/6636be3df9c7493780dd443fc287610d
Autor:
Safina Abdul Razzak, Kiran Iqbal Masood, Rabia Hussain, Syed Faisal Mahmood, Iffat Khanum, Najia Karim Ghanchi, Asghar Nasir, Zahra Hasan, Maliha Yameen, Bushra Jamil, Javeria Ashraf, Akbar Kanji, Martin E. Rottenberg, Nosheen Nasir, Saba Shahid
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe
Autor:
Ruining Liu, Victoria Muliadi, Wenjun Mou, Hanxiong Li, Juan Yuan, Johan Holmberg, Benedict J. Chambers, Nadeem Ullah, Jakob Wurth, Mohammad Alzrigat, Susanne Schlisio, Berit Carow, Lars Gunnar Larsson, Martin E. Rottenberg
Publikováno v:
Nature Communications. 13