Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Martin Donnelley"'
Autor:
Nicole Reyne, Ronan Smith, Patricia Cmielewski, Nina Eikelis, Mark Lawrence, Jennie Louise, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Two cystic fibrosis (CF) rat models, one carrying the common Phe508del mutation and the other a nonsense cystic fibrosis transmembrane conductance regulator (CFTR) mutation (knockout) were previously characterised. Although relevant CFTR mRN
Externí odkaz:
https://doaj.org/article/f30e6698146645fa9909c5f556e1586c
Autor:
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena Schneider-Futschik, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/725af926fa9c429f9377c586aaa5b7a7
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, Rainer Schreiber, Gabriella diStefano, Dorothee Römermann, Ursula Seidler, Martin Donnelley, Karl Kunzelmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated
Externí odkaz:
https://doaj.org/article/06c1135f56334127a708313a72426579
Autor:
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena Schneider-Futschik, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction:Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies
Externí odkaz:
https://doaj.org/article/d6e52064a46e407fbcacadcbcf9524f1
Autor:
Jessica Phillips, Andrew Tai, David Parsons, Kristin Carson-Chahhoud, Matthew Bruorton, Martin Donnelley, Thomas Goddard, Antonia O’Connor
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Cystic fibrosis (CF) is a life-limiting autosomal recessive genetic condition. It is caused by mutations in the gene that encodes for a chloride and bicarbonate conducting transmembrane channel. X-ray velocimetry (XV) is a novel form of
Externí odkaz:
https://doaj.org/article/c9d7366ec56243f68eb9f6a3b0e3f6c6
Autor:
Danni Li, Yimin Zhu, Martin Donnelley, David Parsons, Mark D. Habgood, Elena K. Schneider-Futschik
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116155- (2024)
Background: The potential effects of the very effective cystic fibrosis triple combination drug, Elexacaftor/Tezacaftor/Ivacaftor (ETI) in pregnancy on prenatal development of offspring remain largely unknown. Research question: We aimed to investiga
Externí odkaz:
https://doaj.org/article/1988b84659a84e33a4a322b4699ef6fa
Autor:
Martin Donnelley, Patricia Cmielewski, Kaye Morgan, Juliette Delhove, Nicole Reyne, Alexandra McCarron, Nathan Rout-Pitt, Victoria Drysdale, Chantelle Carpentieri, Kathryn Spiers, Akihisa Takeuchi, Kentaro Uesugi, Naoto Yagi, David Parsons
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Gene vectors to treat cystic fibrosis lung disease should be targeted to the conducting airways, as peripheral lung transduction does not offer therapeutic benefit. Viral transduction efficiency is directly related to the vector residence ti
Externí odkaz:
https://doaj.org/article/8e5066133a14494fa29a90749fcb2c7c
To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Cystic fibrosis (CF) lung disease is characterised by recurring bacterial infections resulting in inflammation, lung damage and ultimately respiratory failure. Pseudomonas aeruginosa is considered one of the most important lung pathogens in those wit
Externí odkaz:
https://doaj.org/article/969e444d6b584b46a13f2b92e4981943
Autor:
Nirajan Shrestha, Nathan Rout-Pitt, Alexandra McCarron, Courtney A. Jackson, Andrew C. Bulmer, Andrew J. McAinch, Martin Donnelley, David W. Parsons, Deanne H. Hryciw
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7194 (2023)
Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR), causes essential fatty acid deficiency. The aim of this study was to characterize fatty acid handling in two rodent models of CF; one strain which har
Externí odkaz:
https://doaj.org/article/1c17e09243904be6b5630c5bff4e9839
Publikováno v:
Journal of Inflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enhances NLRP3 inflammaso
Externí odkaz:
https://doaj.org/article/38b6d4bd2fd849b69fa1e93a0d78ff0c