Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Martin Di Grandi"'
Autor:
Nancy Torres, Eileen Frommer, Bloom Jonathan David, Karen Collins, Dunnick Alejandro Lee, George Diamantidis, Yongbo Hu, Minu Dutia, Christoph W. Zapf, Zhang Chunchun, Darrin William Hopper, Dan Maarten Berger, Donald Wojciechowicz, Dennis Powell, Martin Di Grandi, Jeremy I. Levin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6957-6961
A novel series of pyrazolo[1,5-a]pyrimidines bearing a 3-hydroxyphenyl group at C(3) and substituted tropanes at C(7) have been identified as potent B-Raf inhibitors. Exploration of alternative functional groups as a replacement for the C(3) phenol d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6346230a46b93ee107f73ab7d8869701
https://doi.org/10.1016/j.bmcl.2009.10.058
https://doi.org/10.1016/j.bmcl.2009.10.058
Autor:
John O'Connell, Yongbo Hu, Girija Krishnamurthy, Amar S. Prashad, Stanley Mullen, Geraldine Bebernitz, Martin Di Grandi, Matthew W. Olson, Amara Luckay, Keith Pitts
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
Two classes of compounds, thiocarbamates 1 and triazoles 2, have been identified as HIV RT RNase H inhibitors using a novel FRET-based HTS assay. The potent analogs in each series exhibited selectivity and were active in cell-based assays. In additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7082b4aef75a0486cf5716173e6e2ef4
https://pubmed.ncbi.nlm.nih.gov/19939680
https://pubmed.ncbi.nlm.nih.gov/19939680
Autor:
Kevin J. Curran, Gregg Feigelson, Bloom Jonathan David, Martin Di Grandi, Amar S. Prashad, Jeanette Fairhurst, Robert J. Visalli, Boris Feld, Ross Adma Antonia
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(16)
The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641e8ba142ad1bc835be58c8bcbacb45
https://pubmed.ncbi.nlm.nih.gov/15261261
https://pubmed.ncbi.nlm.nih.gov/15261261
Autor:
Bloom Jonathan David, George A. Ellestad, Weidong Ding, Kevin J. Curran, Ellen Z. Baum, Miriam Rossi, Stanley A. Lang, Geraldine Bebernitz, Martin Di Grandi
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(20)
The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f1036e5c977d4003aa9da769eb950f
https://pubmed.ncbi.nlm.nih.gov/14505653
https://pubmed.ncbi.nlm.nih.gov/14505653