Výsledky vyhledávání - "Martin De Cecco"

What makes a good antibody–drug conjugate?

Autor: Lisa L McDermott, Martin De Cecco, Daniel N Galbraith

Publikováno v: Expert Opinion on Biological Therapy. 21:841-847

Introduction: Antibody-Drug Conjugates (ADCs) are becoming increasingly important weapons in the fight against cancer, as evidenced by the growing number of approved products. The complex nature of an ADC means that there is a vast array of choices t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128da5c41ca46aaa2cc22fb245e77fdb
https://doi.org/10.1080/14712598.2021.1880562

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Characterisation of glycoproteins using a quadrupole time-of-flight mass spectrometer configured for electron transfer dissociation

Autor: Johannes P. C. Vissers, Ying Qing Yu, Martin De Cecco, Asish B. Chakraborty, Steven Derek Pringle, Jonathan P. Williams, Stephane Houel, Lee A. Gethings, Keith Richardson, Jeffery Mark Brown, Weibin Chen

Publikováno v: Rapid Communications in Mass Spectrometry. 27:2383-2390

RATIONALE Electron transfer dissociation (ETD) within ion trapping mass spectrometers has proven to be a useful tool for the characterisation of post-translational modifications. In this study, we describe the implementation of ETD upon a modified qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::064f5d5f5afbff8ac9781758a79241c3
https://doi.org/10.1002/rcm.6684

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Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement

Autor: Julia R. Dorin, Natalie L. Reynolds, Martin De Cecco, Derek Macmillan, Luiz Fernando Arruda Santos, Perdita E. Barran

Publikováno v: ChemBioChem. 12:2133-2136

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fa3e12dac809e6df14297da0dde759
https://doi.org/10.1002/cbic.201100364

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Interaction of Human β-Defensin 2 (HBD2) with Glycosaminoglycans

Autor: Dušan Uhrín, Dominic J. Campopiano, Emily S. Seo, Perdita E. Barran, Bärbel S. Blaum, Thomas Vargues, Malcolm Lyon, Martin De Cecco, Jon A. Deakin

Publikováno v: Seo, E S, Blaum, B S, Vargues, T, De Cecco, M, Deakin, J A, Lyon, M, Barran, P E, Campopiano, D J & Uhrín, D 2010, ' Interaction of Human beta-Defensin 2 (HBD2) with Glycosaminoglycans ', Biochemistry, vol. 49, no. 49, pp. 10486–10495 . https://doi.org/10.1021/bi1011749

Human β-defensin 2 (HBD2) is a member of the defensin family of antimicrobial peptides that plays important roles in the innate and adaptive immune system of both vertebrates and invertebrates. In addition to their direct bactericidal action, defens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9bdc37c9a2bd4ffcd252afd57dfd82
https://doi.org/10.1021/bi1011749

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Isoleucine/leucine2 is essential for chemoattractant activity of β-defensin Defb14 through chemokine receptor 6

Autor: Christine Tyrrell, Martin De Cecco, Derek Macmillan, Fiona Kilanowski, Dominic J. Campopiano, Natalie L. Reynolds, Perdita E. Barran, Julia R. Dorin

Publikováno v: Molecular Immunology. 47:1378-1382

beta-Defensins are both antimicrobial and able to chemoattract various immune cells including immature dendritic cells and CD4 T cells through CCR6. They are short, cationic peptides with a highly conserved six-cysteine motif. It has been shown that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa5acb6abc4fd4e83cd4df54691f910
https://doi.org/10.1016/j.molimm.2009.11.025

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Conformational Preferences of Linear β-Defensins Are Revealed by Ion Mobility-Mass Spectrometry

Autor: Dominic J. Campopiano, Bryan J. McCullough, Martin De Cecco, Julia R. Dorin, K. J. Taylor, Emily S. Seo, Perdita E. Barran, Derek Macmillan, David Clarke

Publikováno v: The Journal of Physical Chemistry B. 114:2312-2318

In recent times there has been an enormous rise in resistance to synthetic antibiotics as well as an increase in the virulence of bacteria, the so-called "superbugs". This problem has catalyzed a search for novel molecules to fight bacteria, which in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacba3252f1381793df54e9575ba17a9
https://doi.org/10.1021/jp9111662

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Multivariate kinetic hard-modelling of spectroscopic data: A comparison of the esterification of butanol by acetic anhydride on different scales and with different instruments

Autor: Yorck-Michael Neuhold, Paul J. Gemperline, Alison Nordon, Martin De Cecco, J. Katy Basford, Maryann Ehly, Graeme Puxty, Konrad Hungerbühler, David Littlejohn, Marc Jecklin

Publikováno v: Chemical Engineering Science. 63:4800-4809

For safety, economic efficiency and environmental efficiency understanding and predicting the behaviour of a chemical reaction are of greatest importance in industry. Hard-modelling, the evolution of a chemical reaction by the rate law derived from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f8f77339a0f6c4d9b46b890452fd9c2
https://doi.org/10.1016/j.ces.2008.01.020

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Shapes of supramolecular cages by ion mobility mass spectrometry

Autor: Paul J. Lusby, Sarah J. Pike, Martin De Cecco, Jakub Ujma, Perdita E. Barran, Chris Moffat, Hannah J. Levene, Oleg Chepelin

Publikováno v: Chemical Communications. 48:4423-4425

Mass spectrometry and drift tube ion mobility mass spectrometry have been used to analyse several isobaric, multicomponent cages yielding information on three dimensional structure, interactions and dynamics of assembly in the gas phase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02160884279d21f3de089fcfe1f8b798
https://doi.org/10.1039/c2cc30778b

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Characterisation of glycoproteins using a quadrupole time-of-flight mass spectrometer configured for electron transfer dissociation

Autor: Jonathan P, Williams, Steven, Pringle, Keith, Richardson, Lee, Gethings, Johannes P C, Vissers, Martin, De Cecco, Stephane, Houel, Asish B, Chakraborty, Ying Qing, Yu, Weibin, Chen, Jeffery M, Brown

Publikováno v: Rapid communications in mass spectrometry : RCM. 27(21)

Electron transfer dissociation (ETD) within ion trapping mass spectrometers has proven to be a useful tool for the characterisation of post-translational modifications. In this study, we describe the implementation of ETD upon a modified quadrupole t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cf24563269bf5502f664d53329c2a77
https://pubmed.ncbi.nlm.nih.gov/24097394

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Peptide Fragments of a β-Defensin Derivative with Potent Bactericidal Activity ▿

Autor: Julia R. Dorin, Dušan Uhrín, Dominic J. Campopiano, Jason M. D. Kalapothakis, Martin De Cecco, Emily S. Seo, John R. W. Govan, Fiona Kilanowski, Natalie L. Reynolds, Chloe Stanton, Perdita E. Barran, Derek Macmillan, K. J. Taylor

Publikováno v: Reynolds, N L, De Cecco, M, Taylor, K, Stanton, C, Kilanowski, F, Kalapothakis, J, Seo, E, Uhrin, D, Campopiano, D, Govan, J, Macmillan, D, Barran, P & Dorin, J R 2010, ' Peptide Fragments of a β-Defensin Derivative with Potent Bactericidal Activity ', Antimicrobial Agents and Chemotherapy, vol. 54, no. 5, pp. 1922-1929 . https://doi.org/10.1128/AAC.01568-09

β-Defensins are known to be both antimicrobial and able to chemoattract various immune cells. Although the sequences of paralogous genes are not highly conserved, the core defensin structure is retained. Defb14-1C V has bactericidal activity similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207f6c8e55806a61e98f4b586696a90c
https://europepmc.org/articles/PMC2863616/

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