Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Martin D Johnson"'
Autor:
Jingyao Wang, Mark R. Berglund, Timothy Braden, Matthew C. Embry, Martin D. Johnson, Stephen R. Groskreutz, Fareed Bhasha Sayyed, Sergey Vladimirovich Tsukanov, Timothy D. White, Ankur Jalan, Kevin D. Seibert, Michael E. Kopach
Publikováno v:
ACS Omega, Vol 7, Iss 50, Pp 46809-46824 (2022)
Externí odkaz:
https://doaj.org/article/0d36177179bf4c10b430c4f3e285bf18
Autor:
Martin D. Johnson, Timothy Braden, Joel R. Calvin, Alison Campbell Brewer, Kevin P. Cole, Scott Frank, Mark Kerr, Doug Kjell, Michael E. Kopach, Joseph R. Martinelli, Scott. A. May, Juan Rincon, Timothy D. White, Matthew H. Yates
Publikováno v:
CHIMIA, Vol 77, Iss 5 (2023)
Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman
Externí odkaz:
https://doaj.org/article/b4057d6508d9480596cdbdfe9135202f
Continuous stirred-tank reactor cascade platform for self-optimization of reactions involving solids
Autor:
Kakasaheb Y. Nandiwale, Travis Hart, Andrew F. Zahrt, Anirudh M. K. Nambiar, Prajwal T. Mahesh, Yiming Mo, María José Nieves-Remacha, Martin D. Johnson, Pablo García-Losada, Carlos Mateos, Juan A. Rincón, Klavs F. Jensen
Publikováno v:
Reaction Chemistry & Engineering. 7:1315-1327
Research-scale fully automated flow platform for reaction self-optimization with solids handling facilitates identification of optimal conditions for continuous manufacturing of pharmaceuticals while reducing amounts of raw materials consumed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931eac995bb5edda2963ade4286f801e
https://doi.org/10.1039/d2re00054g
https://doi.org/10.1039/d2re00054g
Autor:
Richard D. Spencer, Jeffrey C. Roberts, Venkata Ramana Reddy, Robert Moylan, Carla V. Luciani, Joel R. Calvin, Christopher L. Burcham, Jennifer McClary Groh, Myers Steven Scott, Scott A. May, Martin D. Johnson, James R. Stout, Luke P. Webster, Aoife P. Corrigan, Raymond A. Boyse, John D. Murphy
Publikováno v:
Organic Process Research & Development. 25:1284-1351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8925596485876e213ebdb446a13d226
https://doi.org/10.1021/acs.oprd.0c00345
https://doi.org/10.1021/acs.oprd.0c00345
Publikováno v:
Biosensors, Vol 3, Iss 4, Pp 360-373 (2013)
We demonstrate a fluorescence lateral flow system that has excellent sensitivity and wide dynamic range. The illumination system utilizes an LED, plastic lenses and plastic and colored glass filters for the excitation and emission light. Images are c
Externí odkaz:
https://doaj.org/article/35af2b5881694824bd775b536544b48b
Autor:
Matthew M. Bio, Hui Li, David Kouvchinov, Scott Alan Frank, Martin D. Johnson, Yuan-Qing Fang, Andrew M. Clausen, Mark S. Kerr, Ian T. Crouch, Jillian W. Sheeran
Publikováno v:
The Journal of organic chemistry. 87(4)
The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous flow process utilizing a Turbo Grignard reagent, N-methylpiperidin-4-ylmagnesium chloride, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b1ab78f78766ee34996ac2090449dc
https://pubmed.ncbi.nlm.nih.gov/34374277
https://pubmed.ncbi.nlm.nih.gov/34374277
Autor:
Richard D. Miller, Kevin P. Cole, Timothy M. Braden, Todd D. Maloney, Bradley M. Campbell, Moussa Boukerche, Christopher K. Lippelt, Brandon J. Reizman, David Mitchell, Derek R. Starkey, Richard F. Cope, Sam Tadayon, Xin Zhang, Ping Huang, Mindy B. Forst, Michael E. Laurila, Molly Hess, Jonas Y. Buser, Jing Chen, Martin Kwok, Baoquan Sun, Martin D. Johnson, Justin L. Burt, Carla V. Luciani
Publikováno v:
Organic Process Research & Development. 23:870-881
Technology transfer of a small volume continuous (SVC) process and Current Good Manufacturing Practices (cGMP) manufacturing of merestinib are described. A hybrid batch-SVC campaign was completed at a contract manufacturing organization under cGMP. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd431b28c4c7db03a4cd9996f224085
https://doi.org/10.1021/acs.oprd.8b00442
https://doi.org/10.1021/acs.oprd.8b00442
Autor:
Mindy B. Forst, Edward W. Conder, Brandon J. Reizman, Timothy M. Braden, Justin L. Burt, Christopher S. Polster, Molly Hess, Kevin P. Cole, Bradley M. Campbell, David Mitchell, Richard F. Cope, Michael E. Laurila, Moussa Boukerche, Martin D. Johnson, Aurpon W. Mitra, Michael R. Heller, Richard D. Miller, Jennifer McClary Groh, Joseph L. Phillips, John R. Howell, Todd D. Maloney
Publikováno v:
Organic Process Research & Development. 23:858-869
Development of a small volume continuous process that used a combination of batch and flow unit operations to manufacture the small molecule oncolytic candidate merestinib is described. Continuous processing was enabled following the identification a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaef0d8d2753aa1c2899452eb9cc8bfd
https://doi.org/10.1021/acs.oprd.8b00441
https://doi.org/10.1021/acs.oprd.8b00441
Autor:
Martin D. Johnson, Vaidyaraman Shankarraman, Luke P. Webster, Scott A. May, Jennifer McClary Groh, Richard D. Spencer, Timothy M. Braden, Christopher S. Polster, Carla V. Luciani
Publikováno v:
Continuous Pharmaceutical Processing ISBN: 9783030415235
Axial dispersion and residence time distribution (RTD) have significant process implications in the design of continuous processes. Low dispersion is better for minimizing time for complete reaction and minimizing deviation boundaries. High dispersio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6f9279d7888fe2e94d049e660133f8
https://doi.org/10.1007/978-3-030-41524-2_3
https://doi.org/10.1007/978-3-030-41524-2_3
Autor:
Zahra Abbasi, Mohamed Hamada Abdel Kodous, Callie W. Babbitt, Peter M. Budd, Zhen Lei Cheng, Tai-Shung Chung, Marc-Olivier Coppens, Joaquin Coronas, Levente Cseri, Yue Cui, Michael K. Danquah, Enrico Drioli, Arzu Ersöz, Xiaolei Fan, Anthony G. Fane, Maria-Chiara Ferrari, Wen Xiao Gai, Ángel Galán-Martín, Andrés González-Garay, Gonzalo Guillén-Gosálbez, John D. Hayler, Istvan T. Horvath, Jaison Jeevanandam, Yilai Jiao, Martin D. Johnson, C. Oliver Kappe, Rüstem Keçili, Kenta Kokado, Bradley P. Ladewig, Alexei Lapkin, Elsa Lasseuguette, Phantisa Limleamthong, Ryan P. Lively, Andrew Livingston, Yao Ma, Kiyoshi Matsuyama, Farhad Moghadam, Chandran Murugan, Masami Naya, Suzana P. Nunes, Kaushik Pal, Ho Bum Park, Camille Petit, Carlos Pozo, Thalappil Pradeep, Ji Soo Roh, Kazuki Sada, Rıdvan Say, Giulia Schukraft, Varsha Sharma, Jae Eun Shin, Richard L. Smith, Anandhakumar Sundaramurthy, Gyorgy Szekely, Kam C. Tam, Panagiotis Trogadas, Bernhardt L. Trout, Ikuo Ushiki, Luigi Vaccaro, Chun Feng Wan, Huanting Wang, Ecevit Yılmaz, Fengyi Zhang, Xiwang Zhang, Xiangliang Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72db45169b158d1d54efcf88f6beb4fe
https://doi.org/10.1016/b978-0-12-814681-1.01002-x
https://doi.org/10.1016/b978-0-12-814681-1.01002-x