Low diagnostic yield and time to diagnostic confirmation results in prolonged use of antimicrobials in critically ill children [version 2; peer review: 2 approved, 1 approved with reservations]

Autor: Martin Curran, Nazima Pathan, M. Estée Török, Stephen Baker, Deborah White, John Clark, Rachel Bousfield, Esther Daubney, Elizabeth Powell, Theodore Gouliouris, Shruti Agrawal, Adam Palmer, Iain Kean, David Inwald

Publikováno v: Wellcome Open Research, Vol 6 (2022)

Background: Broad-spectrum antimicrobial therapy is a key driver of antimicrobial resistance. Here, we aimed to review indications for antimicrobial therapy, determine the proportion of suspected bacterial infections that are confirmed by culture, an

Externí odkaz: https://doaj.org/article/3e43f624bf35490c855554d8b03b6ac5

Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant

Autor: Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M. Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C. James, Katarzyna A. Ciazynska, Xiaoli Xiong, John A.G. Briggs, James A. Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A. Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth G.C. Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K. Gupta, Stephen Baker, Gordon Dougan, Ravi Gupta, Paul J. Lehner, Paul Lyons, Nicholas J. Matheson, Mark Toshner, Michael P. Weekes, Nick Brown, Martin Curran, Surendra Palmar, David Enoch, Daniel Chapman, Ashley Shaw, Sherly Jose, Areti Bermperi, Julie Ann Zerrudo, Evgenia Kourampa, Laura Watson, Jieniean Worsley, Caroline Saunders, Ranalie de Jesus, Jason Domingo, Ciro Pasquale, Bensi Vergese, Phoebe Vargas, Marivic Fabiculana, Marlyn Perales, Lee Mynott, Elizabeth Blake, Amy Bates, Anne-Laure Vallier, Alexandra Williams, David Phillips, Edmund Chiu, Alex Overhill, Nicola Ramenatte, Jamal Sipple, Steven Frost, Helena Knock, Richard Hardy, Emily Foster, Fiona Davidson, Viona Rundell, Purity Bundi, Richmond Abeseabe, Sarah Clark, Isabel Vicente, Anne Elmer, Carla Ribeiro, Jenny Kourampa, Jane Kennet, Jane Rowlands, Anne Meadows, Criona O’Brien, Rebecca Rastall, Cherry Crucusio, Sarah Hewitt, Jane Price, Jo Calder, Laura Canna, Ashlea Bucke, Hugo Tordesillas, Julie Harris, Valentina Ruffolo, Barbara Graves, Helen Butcher, Daniela Caputo, Emma Le Gresley, Benjamin J. Dunmore, Jennifer Martin, Ekaterina Legchenko, Carmen Treacy, Christopher Huang, Jennifer Wood, Rachel Sutcliffe, Josh Hodgson, Joy Shih, Stefan Graf, Zhen Tong, Tobias Tilly, Ciara O’Donnell, Kelvin Hunter, Linda Pointon, Nicole Pond, Marta Wylot, Emma Jones, Stuart Fawke, Ben Bullman, Lori Turner, Isobel Jarvis, Ommar Omarjee, Aloka De Sa, Joe Marsden, Ariana Betancourt, Marianne Perera, Maddie Epping, Nathan Richoz, Georgie Bower, Rahul Sharma, Francesca Nice, Oisin Huhn, Natalia Savoinykh Yarkoni, Nika Romashova, Daniel Lewis, Andrew Hinch, Chiara Cossetti, Mateusz Strezlecki, Richard Grenfell, Hannah Stark, Neil Walker, Kathy Stirrups, Nigel Ovington, Eleanor Dewhust, Emily Li, Sofia Papadia, Nathalie Kingston, Andrew Lever, Estee Torok, William Hamilton, Grant Hall, Aminu Jahun, Yasmin Chaudhry, Malte Pinckert, Iliana Georgana, Anna Yakovleva, Laura Caller, Sarah Caddy, Theresa Feltwell, Fahad Khokhar, Luke Meredith, Charlotte Holdcroft, Surendra Parmar

Publikováno v: Cell Reports Medicine, Vol 1, Iss 6, Pp 100099- (2020)

Summary: Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%–50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant dominates the p

Externí odkaz: https://doaj.org/article/f56b9ae7c1d24d12996d40bd0463ae07

Respiratory infections in elderly people: Viral role in a resident population of elderly care centers in Lisbon, winter 2013–2014

Autor: Maria-Jesus Chasqueira, Paulo Paixão, Maria-Lúcia Rodrigues, Cátia Piedade, Iolanda Caires, Teresa Palmeiro, Maria-Amalia Botelho, Madalena Santos, Martin Curran, Raquel Guiomar, Pedro Pechirra, Inês Costa, Ana Papoila, Marta Alves, Nuno Neuparth

Publikováno v: International Journal of Infectious Diseases, Vol 69, Iss , Pp 1-7 (2018)

Objective: The aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents. Methods: Nasopharyngeal swabs were collected wh

Externí odkaz: https://doaj.org/article/c588993bd16c4ee8840b6576ccbf976d

P48 The limited yield of cultures in the critically ill child

Autor: John Clark, Deborah White, Esther Daubney, Martin Curran, Rachel Bousfield, Theodore Gouliouris, Elizabeth Powell, Adam Palmer, Shruti Agrawal, David Inwald, Iain Kean, M. Estée Török, Stephen Baker, Nazima Pathan

Publikováno v: JAC-Antimicrobial Resistance. 4

Background Broad-spectrum antimicrobial therapy is a key driver of antimicrobial resistance. Here, we aimed to review indications for antimicrobial therapy, determine the proportion of suspected bacterial infections that are confirmed by culture, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e51eb2299862d5e94327019233bb5752
https://doi.org/10.1093/jacamr/dlac004.047

Towards accurate exclusion of neonatal bacterial meningitis: a feasibility study of a novel 16S rDNA PCR assay

Autor: Arthur Abelian, Thomas Mund, Martin Curran, Stuart Savill, Nipa Mitra, Carol Charan, Amanda Ogilvy-Stuart, Hugh Pelham, Paul Dear

Background: PCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of cerebro-spinal fluid (CSF). The assay’s potential for accurate, fast and inexpensive discriminat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711385ff928d4c1c1683eb4068336677
https://doi.org/10.21203/rs.2.17647/v2