Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Martin Coupal"'
Autor:
Jennifer M. A. Laird, Giovanni Martino, Patricia Schroeder, Dan Widzowski, Vijayaratnam Santhakumar, Mattias Lindberg, Michael W. Wood, Johan Sandin, Martin Coupal, Manon Valiquette
Publikováno v:
Neuropharmacology. 123:233-241
Although the muscarinic receptor family has long been a source of potentially compelling targets for small molecule drug discovery, it was difficult to achieve agonist selectivity within the family. A new class of M1 muscarinic agonists has emerged,
Autor:
Martin Coupal, Nektaria Markoglou, Fraser McIntosh, Carole Puma, Jennifer M. A. Laird, Xiao Hong Yu, Martin N. Perkins, Giovanni Martino, Annie-Kim Gilbert
Publikováno v:
Pain. 152:2852-2860
The role of muscarinic receptor subtype-1 (M1) in chronic pain is unclear. In an attempt to gain an understanding of its role, we have tested xanomeline, an M1/M4-preferring agonist, together with nonselective (scopolamine and pirenzepine), and selec
Autor:
Martin Coupal, Paul Jones, Lejla Hodzic, Wenhau Xiao, Edward Roberts, Andrew Griffin, Daniel Delorme, Dominic Salois, Maryse Labarre, Stephane St-Onge, Christopher Walpole, Jamie Boulet, Lars Gawell, Rico Lavoie, Joanne Butterworth, William Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5994-5998
We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus
Autor:
Johan Sandin, Jennifer M. A. Laird, Patricia Schroeder, Giovanni Martino, Dan Widzowski, Mattias Lindberg, Martin Coupal, Manon Valiquette, Vijayaratnam Santhakumar, Michael Wood
Publikováno v:
The FASEB Journal. 27
Autor:
Marie Roumi, Dominic Salois, Christopher Walpole, Lynda Adam, William Brown, Mylene Gosselin, Pierre-Emmanuel Morin, Andrew Griffin, Martin Coupal
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the
Autor:
Lejla Hodzic, Martin Coupal, Chris Dockendorff, Lautens Mark, Christopher Walpole, Nathan Spear, Shujuan Jin, Madeline Olsen, Kemal Payza, Tomaszewski Miroslaw
Publikováno v:
ChemInform. 40
Autor:
Lejla Hodzic, Chris Dockendorff, Tomaszewski Miroslaw, Shujuan Jin, Christopher Walpole, Mark Lautens, Nathan Spear, Martin Coupal, Kemal Payza, Madeline Olsen
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(4)
A series of 1-aminotetralin scaffolds was synthesized via metal-catalyzed ring-opening reactions of heterobicyclic alkenes. Small libraries of amides and amines were made using the amino group of each scaffold as a handle. Screening of these librarie
Autor:
Christian Jossart, André De Léan, Alain Fournier, N. McNicoll, Martin Coupal, Brian C. Wilkes
Publikováno v:
Biochemistry
Biochemistry, American Chemical Society, 2005, 44 (7), pp.2397-408. ⟨10.1021/bi048251y⟩
Biochemistry, American Chemical Society, 2005, 44 (7), pp.2397-408. ⟨10.1021/bi048251y⟩
International audience; Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are loop-shaped peptidic hormones that have multiple actions on body fluid homeostasis. Their physiological effects are mediated through the activation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7eb27c52aa49e2582eafdc906e10091
https://hal-riip.archives-ouvertes.fr/pasteur-00820032
https://hal-riip.archives-ouvertes.fr/pasteur-00820032
Autor:
Martin Coupal, Mylene Gosselin, Maryse Labarre, Daniel Bellemare, William Brown, Kemal Payza, Page Daniel, Angela Naismith, Ralf Schmidt
Publikováno v:
Journal of medicinal chemistry. 44(15)
The design, synthesis and pharmacological evaluation of a novel class of Dmt-Tic dipeptide analogues are described. These resulting analogues bearing different C-terminal functionalities were found to bind to the human delta receptor with high affini
Publikováno v:
Biochemical and biophysical research communications. 258(1)
Two Nalpha-benzophenone-substituted photoprobes, derived from the high affinity NPR-A chimeric agonist [N, C, rANP(1-28)]pBNP32 (pBNP1) were assembled by solid-phase peptide synthesis. [Nalpha-p-benzoylbenzoyl, Tyr2]pBNP1 (probe A), and [Nalpha-p-ben