CH-01 is a Hypoxia-Activated Prodrug That Sensitizes Cells to Hypoxia/Reoxygenation Through Inhibition of Chk1 and Aurora A

Autor: Ester M. Hammond, Liam J O'Connor, Monica M. Olcina, Martin Christlieb, Samuel C. Grayer, Isabel M. Pires, Stuart J. Conway, I Diane Swallow, Cindy Cazares-Körner

Publikováno v: ACS Chemical Biology
Cazares-Körner, C, Pires, IM, Swallow, ID, Grayer, SC, O'Connor, LJ, Olcina, MM, Christlieb, M, Conway, SJ & Hammond, EM 2013, ' CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A ', ACS chemical biology, vol. 8, no. 7, pp. 1451-1459 . https://doi.org/10.1021/cb4001537

The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462266bd2f7e91a170e9b36c04d27c7c
https://doi.org/10.1021/cb4001537

Functionalised bicyclic alcohols by enantioselective alpha-deprotonation-rearrangement of meso-epoxides

Autor: Gary P. Lee, David M. Hodgson, Rebecca Green, Iain D. Cameron, Lesley A. Robinson, Martin Christlieb

Enantioselective α-deprotonation–rearrangement of achiral substituted cyclooctene oxides 7, 27 and 28 and N-Boc hexahydroazonine oxide 45 using organolithiums in the presence of (−)-sparteine 3 or (−)-α-isosparteine 4 gives the functionalised

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https://ora.ox.ac.uk/objects/uuid:ab2698f1-910d-409c-9aad-8c00bdf0ed62

The exocyclic functionalisation of bis(thiosemicarbazonate) complexes of zinc and copper: the synthesis of monomeric and dimeric species

Autor: Paul D. Bonnitcha, Jonathan R. Dilworth, Harriet S. R. Struthers, Andrew R. Cowley, Martin Christlieb

This paper reports the synthesis of bimetallic zinc thiosemicarbazone complexes with rigid aromatic linkers, using either 1,3- or 1,4- benzenediamines or 1,3- or 1,4- benzenedialdehydes as the basis of the linking groups. Non-rigid aliphatic diamines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011a5b210b48bb8790e71ad33989d127
https://ora.ox.ac.uk/objects/uuid:8c629ffc-5575-4429-bf24-68b9ef9551f3

A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo

Autor: Matthew Tredwell, Antony D. Gee, Kamila Hussien, Bart Cornelissen, Martin Christlieb, Rebekka Hueting, Jan Passchier, Jonathan R. Dilworth, Véronique Gouverneur, Ruth J. Muschel, Veerle Kersemans, Sean Smart

(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clinically as a PET agent both for delineation of tumor hypoxia and as an effective indicator of patient prognosis, but there are still aspects of the mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afce5facae138f9ef4ce88aca8a496c
https://ora.ox.ac.uk/objects/uuid:1db13ad7-3d1e-4239-8f21-71eaf038342d

On the Use of Low-Pass Filters for Image Processing with Inverse Laplacian Models

Autor: Michael Brady, Martin Christlieb, Mark Gooding, Tunde Szilagyi, Rehan Ali

A novel signal processing-oriented approach to solving problems involving inverse Laplacians is introduced. The Monogenic Signal is a powerful method of computing the phase of discrete signals in image data, however it is typically used with band-pas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09a733c571e5e635af143c11d1507af
https://doi.org/10.1007/s10851-011-0299-6