Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Martin Chalfie"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 4, Pp 1121-1130 (2016)
The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo. Loss of MEC-6, a
Externí odkaz:
https://doaj.org/article/90645747ecc446a19a4c778da4587ab0
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1343-1352 (2015)
Cell differentiation usually occurs with high fidelity, but the expression of many transcription factors is variable. Using the touch receptor neurons (TRNs) in C. elegans, we found that the Hox proteins CEH-13/lab and EGL-5/Abd-B overcome this varia
Externí odkaz:
https://doaj.org/article/c80218ccba2040bc9bfb0278ab45ddc7
Autor:
Melissa Kelley, John Yochem, Michael Krieg, Andrea Calixto, Maxwell G Heiman, Aleksandra Kuzmanov, Vijaykumar Meli, Martin Chalfie, Miriam B Goodman, Shai Shaham, Alison Frand, David S Fay
Publikováno v:
eLife, Vol 4 (2015)
During development, biomechanical forces contour the body and provide shape to internal organs. Using genetic and molecular approaches in combination with a FRET-based tension sensor, we characterized a pulling force exerted by the elongating pharynx
Externí odkaz:
https://doaj.org/article/cdd7a4efc098416da962749cc95e830a
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004017 (2013)
Although epigenetic control of stem cell fate choice is well established, little is known about epigenetic regulation of terminal neuronal differentiation. We found that some differences among the subtypes of Caenorhabditis elegans VC neurons, partic
Externí odkaz:
https://doaj.org/article/ffe360ead7e340c6859867ce06456ce2
Autor:
A. Sophia Gayek, Susan Laura Javier Jao, Natalie Yvonne Sayegh, Martin Chalfie, Chaogu Zheng, Ho Ming Terence Lee
Publikováno v:
Molecular Biology of the Cell. 32:331-347
This study describes an updated collection of 99 tubulin missense mutations for their effects on neurite growth in Caenorhabditis elegans. Structural modeling found mutations often cluster and generate steric clashes. Genetic studies identified compl
Autor:
Martin Chalfie
Publikováno v:
Nature's Gift to Neuroscience ISBN: 9781003239758
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f9ae8b0a10ed4c7e85e2234ac8e6c4
https://doi.org/10.1201/9781003239758-5
https://doi.org/10.1201/9781003239758-5
Autor:
Martin Chalfie
Publikováno v:
Developmental Biology. 455:113-361
Publikováno v:
Nature. 597(7875)
Autor:
Martin Chalfie
Publikováno v:
Journal of neurogenetics. 34(3-4)
A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with
Autor:
Ho Ming Terence, Lee, Natalie Yvonne, Sayegh, A Sophia, Gayek, Susan Laura Javier, Jao, Martin, Chalfie, Chaogu, Zheng
Publikováno v:
Molecular Biology of the Cell
Mutations in tubulins affect microtubule (MT) dynamics and functions during neuronal differentiation and their genetic interaction provides insights into the regulation of MT functions. We previously used Caenorhabditis elegans touch receptor neurons