Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Martin Casper"'
Autor:
Bryan A. Kramer, Kevin Whelan, Yoshinori Sekiguchi, Shigeyuki Chaki, Pureza Vallar, Michael Morgan, Graeme Semple, Thuy-Anh Tran, William Thomsen, Dipanjan Sengupta, Juyi Choi, Debbie Hsu, Andrew J. Grottick, Kosuke Kanuma, Erin K. Hauser, Ning Zou, Martin Casper, Sangdon Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6166-6171
A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was not
Autor:
Bill Thomsen, Mariko Nishiguchi, Debbie Hsu, Graeme Semple, Katsunori Omodera, Bryan A. Kramer, Kosuke Kanuma, Takeo Funakoshi, Martin Casper, Thuy-Anh Tran, Yoshinori Sekiguchi, Shigeyuki Chaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3853-3856
The optimization of a series of 4-(dimethylamino)quinazoline antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. The combination of the elaboration of both the linker portion and the terminal phenyl ring provided N-(cis
Publikováno v:
Chest. 149:A536
Autor:
Abu J.M. Sadeque, Michael Morgan, Marc Decaire, Honnappa Jayakumar, Lan Pham, John W. Adams, Graeme Semple, Jin-Sun Karoline Choi, Konrad Feichtinger, Yifeng Xiong, Bradley Teegarden, John Frazer, Diane Yuskin, Sonja Strah-Pleynet, Weichao Chen, Brett Ullman, Robert R. Webb, Hussien A. Al-Shamma, Martin Casper, Peter I. Dosa, Daniel T. Connolly
Publikováno v:
Journal of medicinal chemistry. 53(11)
Serotonin, which is stored in platelets and is released during thrombosis, activates platelets via the 5-HT(2A) receptor. 5-HT(2A) receptor inverse agonists thus represent a potential new class of antithrombotic agents. Our medicinal program began wi
Autor:
Peter I. Dosa, Marc Decaire, Martin Casper, Juerg Lehmann, Katie Elwell, Juan Ramirez, Yifeng Xiong, John W. Adams, Amy Siu-Ting Wong, Graeme Semple, Karoline Choi, Honnappa Jayakumar, Jeremy G. Richman, Bradley Teegarden, William Thomsen, Robert R. Webb, Sonja Strah-Pleynet
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(18)
Potent 5-HT 2A inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated hum
Autor:
Debbie Hsu, Thuy-Anh Tran, Nigel Robert Arnold Beeley, Kosuke Kanuma, Bill Thomsen, Mariko Nishiguchi, Graeme Semple, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Bryan A. Kramer, Katsunori Omodera, Martin Casper
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(10)
A series of 4-(dimethylamino)quinazoline based antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. This series was derived from a lead compound, AR129330, identified by HTS of a GPCR-directed library using a functional