Resolving Human Lactation Heterogeneity Using Single Milk-Derived Cells, a Resource at the Ready.

Autor: Martin Carli JF; Section of Nutrition, Denver Anschutz Medical Campus Department of Pediatrics, University of Colorado, Aurora, CO, 80045, USA. jayne.martincarli@cuanschutz.edu., Trahan GD; Section of Hematology, Oncology, and Bone Marrow Transplant, Denver Anschutz Medical Campus Department of Pediatrics, University of Colorado, Aurora, CO, 80045, USA., Rudolph MC; Department of Physiology, Oklahoma University Health Sciences Center, Oklahoma City, OK, 73104, USA.

Publikováno v: Journal of mammary gland biology and neoplasia [J Mammary Gland Biol Neoplasia] 2021 Mar; Vol. 26 (1), pp. 3-8. Date of Electronic Publication: 2021 Jun 07.

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

Autor: Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K. h.yaghootkar@exeter.ac.uk tuomas.kilpelainen@sund.ku.dk.; Division of Medical Sciences, Department of Health Sciences, Luleå University of Technology, Luleå, Sweden.; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, U.K., Zhang Y; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY., Spracklen CN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA., Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; DTU Health Technology, Technical University of Denmark, Lyngby, Denmark., Huang LO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bradfield J; Center for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.; Quantinuum Research LLC, San Diego, CA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Fine RS; Department of Genetics, Harvard Medical School, Boston, MA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Kutalik Z; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Wittemans LBL; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, and Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN., Metz S; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Willems SM; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Molnos S; German Center for Diabetes Research, München-Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany., Sandoval-Zárate AA; Institute for Molecular Medicine Finland, Helsinki, Finland., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD.; Data Tecnica International, Glen Echo, MD., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado-Denver, Denver, CO., Haesser J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Venturini C; Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Kacprowski T; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Wang CA; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Amin N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Broer L; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Robertson N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Young KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC., Allison M; Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA., Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI., Blüher M; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Borja JB; Office of Population Studies Foundation, Inc., Cebu City, Philippines.; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Carrasquilla GD; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christofidou P; Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Doege CA; Department of Pathology and Cell Biology, Columbia University, New York, NY., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.; Carolina Center for Genome Sciences, Chapel Hill, NC., Guo K; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY., Hakonarson H; Center for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Hong J; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Jackson R; Division of Endocrinology, Diabetes, and Metabolism, Ohio State University, Columbus, OH., Jakupović H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jousilahti P; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Justice AE; Center for Biomedical and Translational Informatics, Geisinger, Danville, PA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kizer JR; Cardiology Section, San Francisco Veterans Affairs Health Care System, University of California San Francisco, San Francisco, CA.; Departments of Medicine and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA., Kriebel J; German Center for Diabetes Research, München-Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany., LeDuc CA; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY., Li J; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Mackey DA; Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, West Australia, Australia., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, U.K., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Martin Carli JF; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY., Medina-Gomez C; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biostatistics, University of Liverpool, Liverpool, U.K.; Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, U.K., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Nauck M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Prokic I; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Pennell CE; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Pradhan AD; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Psaty BM; Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, Turku, Finland., Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Skaaby T; Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, Insitute of Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, Ludwig Maximilian University Munich, München, Germany., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Teumer A; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Uitterlinden AG; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Wu Y; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Walker M; Institute of Cellular Medicine (Diabetes), Newcastle University, Newcastle upon Tyne, U.K., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC., Kovacs P; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Lye S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Ingelsson E; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA.; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Spector TD; Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K., McKnight B; Department of Biostatistics, University of Washington, Seattle, WA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Adair LS; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Reiner AP; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD., Ripatti S; Broad Institute of MIT and Harvard, Cambridge, MA.; Institute for Molecular Medicine Finland, Helsinki, Finland.; Public Health, University of Helsinki, Helsinki, Finland., Grallert H; German Center for Diabetes Research, München-Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany., Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, MA., Salomaa V; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Willems van Dijk K; Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Grant SFA; Center for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Center for Spatial and Functional Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.; Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA.; Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Broad Institute of MIT and Harvard, Cambridge, MA.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, U.K., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Leibel RL; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark h.yaghootkar@exeter.ac.uk tuomas.kilpelainen@sund.ku.dk.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY.

Publikováno v: Diabetes [Diabetes] 2020 Dec; Vol. 69 (12), pp. 2806-2818. Date of Electronic Publication: 2020 Sep 11.

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Autor: Stratigopoulos G; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. Electronic address: gs2172@columbia.edu., Martin Carli JF; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., O'Day DR; Divisions of Developmental Medicine and Genetic Medicine, Department of Pediatrics, Seattle Children's Research Institute and University of Washington 1959 NE Pacific St, Seattle, WA 98195, USA., Wang L; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Leduc CA; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Lanzano P; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Chung WK; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Rosenbaum M; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Egli D; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Doherty DA; Divisions of Developmental Medicine and Genetic Medicine, Department of Pediatrics, Seattle Children's Research Institute and University of Washington 1959 NE Pacific St, Seattle, WA 98195, USA., Leibel RL; Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. Electronic address: rl232@columbia.edu.

Publikováno v: Cell metabolism [Cell Metab] 2014 May 06; Vol. 19 (5), pp. 767-79.