Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Martin Caffrey"'
Autor:
Coilín Boland, Chia-Ying Huang, Shiva Shanker Kaki, Meitian Wang, Vincent Olieric, Martin Caffrey
Publikováno v:
Crystals, Vol 13, Iss 9, p 1402 (2023)
Both intensity and phase information are needed for structure determination by macromolecular X-ray crystallography. The diffraction experiment provides intensities. Phases must be accessed indirectly by molecular replacement, or by experimental phas
Externí odkaz:
https://doaj.org/article/5c89fea58bcb460cbe8b99cd4d1a2b11
Autor:
Samir Olatunji, Katherine Bowen, Chia-Ying Huang, Dietmar Weichert, Warispreet Singh, Irina G. Tikhonova, Eoin M. Scanlan, Vincent Olieric, Martin Caffrey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
In Gram-positive bacteria, lipoprotein intramolecular transacylase Lit produces a lipoprotein variant with less immunogenicity. As such, Lit can be viewed as a virulence factor. Here, structural and functional characterization of the enzyme provides
Externí odkaz:
https://doaj.org/article/03baf9b973b44bc2873d0ae3f2a3b65a
Autor:
Isabelle Martiel, Chia-Ying Huang, Pablo Villanueva-Perez, Ezequiel Panepucci, Shibom Basu, Martin Caffrey, Bill Pedrini, Oliver Bunk, Marco Stampanoni, Meitian Wang
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1131-1141 (2020)
Serial protein crystallography has emerged as a powerful method of data collection on small crystals from challenging targets, such as membrane proteins. Multiple microcrystals need to be located on large and often flat mounts while exposing them to
Externí odkaz:
https://doaj.org/article/f0fc2a49b4e14a08bb736f1b42e25766
Autor:
Samir Olatunji, Xiaoxiao Yu, Jonathan Bailey, Chia-Ying Huang, Marta Zapotoczna, Katherine Bowen, Maja Remškar, Rolf Müller, Eoin M. Scanlan, Joan A. Geoghegan, Vincent Olieric, Martin Caffrey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profou
Externí odkaz:
https://doaj.org/article/01038f4ee14b4c098398c5a500858933
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Lipoproteins are some of the most abundant proteins in bacteria. With a lipid anchor to the cell membrane, they function as enzymes, inhibitors, transporters, structural proteins, and as virulence factors. Lipoproteins activate the innate immune syst
Externí odkaz:
https://doaj.org/article/af9321fd475c433c9ad2b1f2840c9e98
Autor:
Meriem El Ghachi, Nicole Howe, Chia-Ying Huang, Vincent Olieric, Rangana Warshamanage, Thierry Touzé, Dietmar Weichert, Phillip J. Stansfeld, Meitian Wang, Fred Kerff, Martin Caffrey
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Bacterial cell wall components are assembled in a transmembrane cycle that involves the membrane integral pyrophosphorylase, BacA. Here the authors solve the crystal structure of BacA which shows an interdigitated inverted topology repeat that hints
Externí odkaz:
https://doaj.org/article/987e6a420d7e43b5beb6875d278ef2d9
Autor:
Maciej Wiktor, Dietmar Weichert, Nicole Howe, Chia-Ying Huang, Vincent Olieric, Coilín Boland, Jonathan Bailey, Lutz Vogeley, Phillip J. Stansfeld, Nienke Buddelmeijer, Meitian Wang, Martin Caffrey
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Lipoproteins are essential components of bacterial membranes. Here the authors present the crystal structures ofPseudomonas aeruginosa and Escherichia coliapolipoprotein N-acyltransferase, which catalyses the final step in the lipoprotein synthesis p
Externí odkaz:
https://doaj.org/article/3e70da5018ac4c64b19755f2a8e71164
Autor:
Satish R. Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis, Matthew D. Zimmerman, Samir Olatunji, Jaeyong Lee, Min Xie, Jansy Sarathy, Martin Caffrey, Natalie C. J. Strynadka, Véronique Dartois, Thomas Dick, Bom Nae Rin Lee, David G. Russell, Eric Oldfield
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::795aa2e7ce9d04ea62216ba0eca39ed4
https://doi.org/10.1021/acs.jmedchem.3c00398
https://doi.org/10.1021/acs.jmedchem.3c00398
Autor:
Lysbeth H. Antonides, Quenton W. Hurst, Callum M. Ives, Kiefer Ramberg, Nikitas Ostrovitsa, Eoin Scanlan, Martin Caffrey, Samantha J. Pitt, Ulrich Zachariae
The function of ion channels is essential in the infectious cycle of many viruses. To facilitate viral uptake, maturation and export, viruses must modify the ionic balance of their host cells, in particular of calcium ions (Ca2+). Viroporins encoded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d31d751cab0f5983039141beeb3b67e
https://doi.org/10.1101/2022.10.11.511775
https://doi.org/10.1101/2022.10.11.511775
Autor:
Pawel, Krawinski, Martin, Caffrey
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2507
G protein-coupled receptors (GPCRs) play vital roles in human physiology and pathophysiology. This makes the elucidation of the high-resolution blueprints of these high value membrane proteins of crucial importance for the structure-based design of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfc55582672a1cedb69186a782d23e58
https://pubmed.ncbi.nlm.nih.gov/35773586
https://pubmed.ncbi.nlm.nih.gov/35773586