Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Martin C Frith"'
Autor:
Shintaro Akamatsu, Satomi Mitsuhashi, Kaima Soga, Heisuke Mizukami, Makoto Shiraishi, Martin C Frith, Yoshihisa Yamano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Variants in mitochondrial genomes (mtDNA) can cause various neurological and mitochondrial diseases such as mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes (MELAS). Given the 16 kb length of mtDNA, continuous se
Externí odkaz:
https://doaj.org/article/c3338d81e20740448b40f32ce166bac4
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54210 (2013)
Human gene catalogs are fundamental to the study of human biology and medicine. But they are all based on open reading frames (ORFs) in a reference genome sequence (with allowance for introns). Individual genomes, however, are polymorphic: their sequ
Externí odkaz:
https://doaj.org/article/4b1f2a6ea84748a9a08c9946ab04f715
Autor:
Martin C Frith
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28819 (2011)
Detection of sequences that are homologous, i.e. descended from a common ancestor, is a fundamental task in computational biology. This task is confounded by low-complexity tracts (such as atatatatatat), which arise frequently and independently, caus
Externí odkaz:
https://doaj.org/article/906f564ab49244dda6c38def8767712a
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 4, p e1000071 (2008)
BIOLOGY IS ENCODED IN MOLECULAR SEQUENCES: deciphering this encoding remains a grand scientific challenge. Functional regions of DNA, RNA, and protein sequences often exhibit characteristic but subtle motifs; thus, computational discovery of motifs i
Externí odkaz:
https://doaj.org/article/c4bcaa1c08354951850c7ba274930266
Autor:
Martin C Frith, Laurens G Wilming, Alistair Forrest, Hideya Kawaji, Sin Lam Tan, Claes Wahlestedt, Vladimir B Bajic, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Timothy L Bailey, Lukasz Huminiecki
Publikováno v:
PLoS Genetics, Vol 2, Iss 4, p e23 (2006)
The mammalian transcriptome harbours shadowy entities that resist classification and analysis. In analogy with pseudogenes, we define pseudo-messenger RNA to be RNA molecules that resemble protein-coding mRNA, but cannot encode full-length proteins o
Externí odkaz:
https://doaj.org/article/73e747585289450d9fbf58e975525f82
Autor:
Masaaki Furuno, Ken C Pang, Noriko Ninomiya, Shiro Fukuda, Martin C Frith, Carol Bult, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, John S Mattick, Harukazu Suzuki
Publikováno v:
PLoS Genetics, Vol 2, Iss 4, p e37 (2006)
Non-protein-coding RNAs (ncRNAs) are increasingly being recognized as having important regulatory roles. Although much recent attention has focused on tiny 22- to 25-nucleotide microRNAs, several functional ncRNAs are orders of magnitude larger in si
Externí odkaz:
https://doaj.org/article/90c32b0d57dc4c4fa87080183428175c
Autor:
Martin C Frith, Alistair R Forrest, Ehsan Nourbakhsh, Ken C Pang, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Timothy L Bailey, Sean M Grimmond
Publikováno v:
PLoS Genetics, Vol 2, Iss 4, p e52 (2006)
Short proteins play key roles in cell signalling and other processes, but their abundance in the mammalian proteome is unknown. Current catalogues of mammalian proteins exhibit an artefactual discontinuity at a length of 100 aa, so that protein abund
Externí odkaz:
https://doaj.org/article/c3347406a504491fa97d734ab41ce88d
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease. One hypothesis is that changeable tandem repeats
Externí odkaz:
https://doaj.org/article/d4df2ba35f544696b270840584726362
Publikováno v:
BMC Medical Genomics, Vol 11, Iss S2, Pp 1-10 (2018)
Abstract Background Reliable detection of genome variations, especially insertions and deletions (indels), from single sample DNA sequencing data remains challenging, partially due to the inherent uncertainty involved in aligning sequencing reads to
Externí odkaz:
https://doaj.org/article/33d84f72a3fb40bc8bd4b5e9e20835bc
Autor:
Martin C. Frith, Satomi Mitsuhashi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629956
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::068fe2a1008438f941700f2a95c1bb6b
https://doi.org/10.1007/978-1-0716-2996-3_12
https://doi.org/10.1007/978-1-0716-2996-3_12
