Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Martin Brodde"'
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A multistep in vitro hemocompatibility testing protocol recapitulating the foreign body reaction to nanocarriers
Autor: Valeria Perugini, Ruth Schmid, Yrr Morch, Isabelle Texier, Martin Brodde, Matteo Santin
Publikováno v: Drug Delivery and Translational Research
The development of drug nanocarriers based on polymeric, lipid and ceramic biomaterials has been paving the way to precision medicine, where the delivery of poorly soluble active compounds and personalized doses are made possible. However, the nano-s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da837addf42a9a71c76de5f6b58efd7
https://doi.org/10.1007/s13346-022-01141-6
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2
Plasmin-Induced Activation of Human Platelets Is Modulated by Thrombospondin-1, Bona Fide Misfolded Proteins and Thiol Isomerases
Autor: Claudia Pielsticker, Kerstin Jurk, Lisa Raum, Martin Brodde, Beate E. Kehrel
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 22
Inflammatory processes are triggered by the fibrinolytic enzyme plasmin. Tissue-type plasminogen activator, which cleaves plasminogen to plasmin, can be activated by the cross-&beta
structure of misfolded proteins. Misfolded protein aggregates a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675cf3bbffe5ec5006be0d9335e73980
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3
Thrombogenicity of the p48 and anti-thrombogenic p48 hydrophilic polymer coating low-profile flow diverters in an in vitro human thrombin generation model
Autor: Martin Brodde, Hermann Monstadt, Ralf Hannes, Hans Henkes, Catrin Bannewitz, Tim Lenz-Habijan, Pervinder Bhogal, Beate E. Kehrel
Publikováno v: Interv Neuroradiol
Objectives The implantation of flow diverters, or stents in general, necessitates the use of dual anti-platelet treatment with typical regimes including aspirin and a P2Y12 inhibitor. This carries an inherent risk of haemorrhage. We sought to compare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b1ab1449aa8744cdf836a047c4e4ef
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85084609583
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5
Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products
Autor: Beate E. Kehrel, Christine Heilmann, Bettina Löffler, Martin Brodde, Hélène Van de Vyver, Muzaffar Hussain, Dirk Holzinger, Anne Bertling, Dirk Reinhardt, Georg Peters, Silke Niemann, Anke C. Fender
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Globalization and migration promote the spread of Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus strains. The toxin PVL is linked to the development of thrombosis in association with osteomyelitis. The mechanisms by which PVL drives
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef8c00e91be75392a716bfdb682a950
https://doi.org/10.1038/s41598-018-20582-z
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6
Oxidation of C-reactive protein by hypochlorous acid leads to the formation of potent platelet activator
Autor: Rafał Szewczyk, Martin Brodde, Magdalena Boncler, Beate E. Kehrel, Radoslaw Bednarek, Emilia Stec-Martyna, Cezary Watala
Publikováno v: International journal of biological macromolecules. 107
We examined the structural and functional consequences of oxidative modification of C-reactive protein (CRP) by hypochlorous acid (HOCl), which can be generated in vivo via the myeloperoxidase/H2O2/Cl- system. HOCl exposure resulted in the oxidation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b383b2299fd635ac3ad1b4138ece5c
https://pubmed.ncbi.nlm.nih.gov/29111269
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8
First characterization of platelet secretion defect in patients with familial hemophagocytic lymphohistiocytosis type 3 (FHL-3)
Autor: Karin Beutel, Kirstin Sandrock-Lang, Lea Nakamura, Anne Bertling, Barbara Zieger, Ansgar Schulz, Sandra Ammann, Udo zur Stadt, Beate E. Kehrel, Martin Brodde
Publikováno v: Blood. 125:412-414
To the editor: Familial hemophagocytic lymphohistiocytosis (FHL), a rare autosomal recessive disorder of lymphocyte cytotoxicity, is caused by mutations in genes encoding perforin (FHL-2) or proteins important for intracellular trafficking/exocytosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::071c0fefc4e11253aab9c8d107048a4b
https://doi.org/10.1182/blood-2014-07-587568
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9
KRP-203, Sphingosine 1-Phosphate Receptor Type 1 Agonist, Ameliorates Atherosclerosis in LDL-R −/− Mice
Autor: Christian Weber, Sandro Sacchi, Fabio Gualtieri, Francesco Potì, Martin Brodde, Gabriele Weißen-Plenz, Jerzy-Roch Nofer, Georg Varga, Manuela Simoni
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1505-1512
Objective— Sphingosine 1-phosphate (S1P) partly accounts for antiatherogenic properties of high-density lipoproteins. We previously demonstrated that FTY720, a synthetic S1P analog targeting all S1P receptors but S1P receptor type 2, inhibits murin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f73f1fa2db68af7b5b48b4f1c3e071
https://doi.org/10.1161/atvbaha.113.301347
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10
State of the Art in Platelet Function Testing
Autor: Martin Brodde, Beate E. Kehrel
Publikováno v: Transfusion Medicine and Hemotherapy. 40:73-86
Platelets perform many functions in hemostasis but also in other areas of physiology and pathology. Therefore, it is obvious that many different function tests have been developed, each one conceived and standardized for a special purpose. This revie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20fb6fb34c97630d5e21be3e29351f6
https://doi.org/10.1159/000350469
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