Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martin Broch-Lips"'
Autor:
Marianne Skals, Martin Broch-Lips, Martin Brandhøj Skov, Anders Riisager, Judith Ceelen, Ole Bækgaard Nielsen, Sorin J. Brull, Hans D. de Boer, Thomas Holm Pedersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While muscle relaxation facilitates surgical procedures and tracheal intubation, adequate recovery of muscle function after surgery is requi
Externí odkaz:
https://doaj.org/article/d6d8337b10cb40b79893895d9f8251c0
Autor:
Ole Bækgaard Nielsen, Osk Halldorsdottir, Martin Broch-Lips, William Alexander Macdonald, Thomas Holm Pedersen
Publikováno v:
Pedersen, T H, Macdonald, W A, Broch-Lips, M, Halldorsdottir, O & Bækgaard Nielsen, O 2021, ' Chloride channel inhibition improves neuromuscular function under conditions mimicking neuromuscular disorders ', Acta Physiologica, vol. 233, no. 2, e13690 . https://doi.org/10.1111/apha.13690
Aim: The skeletal muscle Cl− channels, the ClC-1 channels, stabilize the resting membrane potential and dampen muscle fibre excitability. This study explored whether ClC-1 inhibition can recover nerve-stimulated force in isolated muscle under condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff25231fe98bc62a68061e127b77af74
https://pure.au.dk/portal/da/publications/chloride-channel-inhibition-improves-neuromuscular-function-under-conditions-mimicking-neuromuscular-disorders(d12ff87d-c942-41c7-afef-61425629b348).html
https://pure.au.dk/portal/da/publications/chloride-channel-inhibition-improves-neuromuscular-function-under-conditions-mimicking-neuromuscular-disorders(d12ff87d-c942-41c7-afef-61425629b348).html
Publikováno v:
The Journal of Physiology. 591:531-545
Resting skeletal muscle fibres have a large membrane Cl(-) conductance (G(Cl)) that dampens their excitability. Recently, however, muscle activity was shown to induce PKC-mediated reduction in G(Cl) in rat muscles of 40-90%. To examine the physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ed5994ad9fe26179e0c2636e459182
https://doi.org/10.1113/jphysiol.2012.243246
https://doi.org/10.1113/jphysiol.2012.243246
Publikováno v:
Broch-Lips, M, Pedersen, T H & Nielsen, O B 2010, ' Effect of purinergic receptor activation on Na +-K + pump activity, excitability, and function in depolarized skeletal muscle ', American Journal of Physiology (Consolidated), vol. 298, no. 6, pp. C1438-C1444 . https://doi.org/10.1152/ajpcell.00361.2009
Activity-induced elevation of extracellular purines and pyrimidines has been associated with autocrine and paracrine signaling in many tissues. Here we investigate the effect of purinergic signaling for the excitability and contractility of depolariz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbc7e14a9b06c84de5764a9e9fd83a2
https://doi.org/10.1152/ajpcell.00361.2009
https://doi.org/10.1152/ajpcell.00361.2009
Autor:
Martin, Broch-Lips, Frank, de Paoli, Thomas Holm, Pedersen, Ole Baekgaard, Nielsen, Ole B, Nielsen, Thomas H, Pedersen, Boubacar, Benziane, Alexander V, Chibalin, Sergej, Pirkmajer, Michael J, McKenna, Craig A, Goodman
Publikováno v:
Journal of Applied Physiology. 112:2124-2126
A commentary on Viewpoint: Maximal Na+-K+-ATPase activity is upregulated in association with muscle activity by C. Juel, published in Journal of Applied Physiology, 112(12), pp. 2121-3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766a17b58430a0a662b80fbb34a6d52f
https://doi.org/10.1152/japplphysiol.00449.2012
https://doi.org/10.1152/japplphysiol.00449.2012
Autor:
Anders Riisager, Ole Bækgaard Nielsen, Thomas Holm Pedersen, Thomas Schmitt-John, Martin Broch-Lips
Publikováno v:
Broch-Lips, M, Pedersen, T H, Riisager, A, Schmitt-John, T & Nielsen, O B 2013, ' Neuro-muscular function in the wobbler murine model of primary motor neuronopathy ', Experimental Neurology, vol. 248, pp. 406-415 . https://doi.org/10.1016/j.expneurol.2013.07.005
The wobbler mouse represents a model for neurodegenerative disease affecting motor neurons. This study explored the importance of fiber type specific changes for the contractile dysfunction of soleus and extensor digitorum longus (EDL) muscles from w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55f7ace6bd3bafc8d44e1802778a8b8
https://pure.au.dk/portal/da/publications/neuromuscular-function-in-the-wobbler-murine-model-of-primary-motor-neuronopathy(e1bfea2d-35e0-41b2-8560-66e02c09b755).html
https://pure.au.dk/portal/da/publications/neuromuscular-function-in-the-wobbler-murine-model-of-primary-motor-neuronopathy(e1bfea2d-35e0-41b2-8560-66e02c09b755).html
Publikováno v:
The Journal of physiology. 591(2)
Resting skeletal muscle fibres have a large membrane Cl(-) conductance (G(Cl)) that dampens their excitability. Recently, however, muscle activity was shown to induce PKC-mediated reduction in G(Cl) in rat muscles of 40-90%. To examine the physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36a071fb993fb48e55f06ff6f4911237
https://pubmed.ncbi.nlm.nih.gov/23045345
https://pubmed.ncbi.nlm.nih.gov/23045345
Publikováno v:
Broch-Lips, M, Pedersen, T H & Nielsen, O B 2012, ' Commentaries on viewpoint: maximal Na⁺-K⁺-ATPase activity is upregulated in association with muscle activity. ', Journal of Applied Physiology, vol. 112, no. 12, pp. 2124-2126 .
Aarhus University
Aarhus University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8a746a9278d85276b45f64f1a7d9ac01
https://pure.au.dk/portal/da/publications/commentaries-on-viewpoint-maximal-nakatpase-activity-is-upregulated-in-association-with-muscle-activity(5cc65e0a-f6be-4530-bc45-90a34b90ddaa).html
https://pure.au.dk/portal/da/publications/commentaries-on-viewpoint-maximal-nakatpase-activity-is-upregulated-in-association-with-muscle-activity(5cc65e0a-f6be-4530-bc45-90a34b90ddaa).html
Publikováno v:
Broch-Lips, M, de Paoli, F V, Overgaard, K & Nielsen, O B 2011, ' Effects of 8 wk of voluntary unloaded wheel running on K+ tolerance and excitability of soleus muscles in rat ', The Journal of Physiology, bind 111 .
Aarhus University
Aarhus University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cf80631d507e7f01eeaab4fb9561913f
https://pure.au.dk/portal/da/publications/effects-of-8-wk-of-voluntary-unloaded-wheel-running-on-k-tolerance-and-excitability-of-soleus-muscles-in-rat(2d19819f-c855-456d-9700-0bbd3a7afcc0).html
https://pure.au.dk/portal/da/publications/effects-of-8-wk-of-voluntary-unloaded-wheel-running-on-k-tolerance-and-excitability-of-soleus-muscles-in-rat(2d19819f-c855-456d-9700-0bbd3a7afcc0).html
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71dbce3d6f5d9c5582f3476b050970e9
https://doi.org/10.1096/fasebj.22.1_supplement.962.8
https://doi.org/10.1096/fasebj.22.1_supplement.962.8