ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats

Autor: Marianne Skals, Martin Broch-Lips, Martin Brandhøj Skov, Anders Riisager, Judith Ceelen, Ole Bækgaard Nielsen, Sorin J. Brull, Hans D. de Boer, Thomas Holm Pedersen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Abstract Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While muscle relaxation facilitates surgical procedures and tracheal intubation, adequate recovery of muscle function after surgery is requi

Externí odkaz: https://doaj.org/article/d6d8337b10cb40b79893895d9f8251c0

Relationship between membrane Cl−conductance and contractile endurance in isolated rat muscles

Autor: Martin Broch-Lips, Ole Bækgaard Nielsen, Frank Vincenzo de Paoli, Thomas Holm Pedersen

Publikováno v: The Journal of Physiology. 591:531-545

Resting skeletal muscle fibres have a large membrane Cl(-) conductance (G(Cl)) that dampens their excitability. Recently, however, muscle activity was shown to induce PKC-mediated reduction in G(Cl) in rat muscles of 40-90%. To examine the physiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5ed5994ad9fe26179e0c2636e459182
https://doi.org/10.1113/jphysiol.2012.243246

Effect of purinergic receptor activation on Na+-K+ pump activity, excitability, and function in depolarized skeletal muscle

Autor: Thomas Holm Pedersen, Ole Bækgaard Nielsen, Martin Broch-Lips

Publikováno v: Broch-Lips, M, Pedersen, T H & Nielsen, O B 2010, ' Effect of purinergic receptor activation on Na +-K + pump activity, excitability, and function in depolarized skeletal muscle ', American Journal of Physiology (Consolidated), vol. 298, no. 6, pp. C1438-C1444 . https://doi.org/10.1152/ajpcell.00361.2009

Activity-induced elevation of extracellular purines and pyrimidines has been associated with autocrine and paracrine signaling in many tissues. Here we investigate the effect of purinergic signaling for the excitability and contractility of depolariz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbc7e14a9b06c84de5764a9e9fd83a2
https://doi.org/10.1152/ajpcell.00361.2009

Neuro-muscular function in the wobbler murine model of primary motor neuronopathy

Autor: Anders Riisager, Ole Bækgaard Nielsen, Thomas Holm Pedersen, Thomas Schmitt-John, Martin Broch-Lips

Publikováno v: Broch-Lips, M, Pedersen, T H, Riisager, A, Schmitt-John, T & Nielsen, O B 2013, ' Neuro-muscular function in the wobbler murine model of primary motor neuronopathy ', Experimental Neurology, vol. 248, pp. 406-415 . https://doi.org/10.1016/j.expneurol.2013.07.005

The wobbler mouse represents a model for neurodegenerative disease affecting motor neurons. This study explored the importance of fiber type specific changes for the contractile dysfunction of soleus and extensor digitorum longus (EDL) muscles from w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55f7ace6bd3bafc8d44e1802778a8b8
https://pure.au.dk/portal/da/publications/neuromuscular-function-in-the-wobbler-murine-model-of-primary-motor-neuronopathy(e1bfea2d-35e0-41b2-8560-66e02c09b755).html

Commentaries on viewpoint: maximal Na⁺-K⁺-ATPase activity is upregulated in association with muscle activity

Autor: Martin Broch-Lips, Thomas Holm Pedersen, Ole Bækgaard Nielsen

Publikováno v: Broch-Lips, M, Pedersen, T H & Nielsen, O B 2012, ' Commentaries on viewpoint: maximal Na⁺-K⁺-ATPase activity is upregulated in association with muscle activity. ', Journal of Applied Physiology, vol. 112, no. 12, pp. 2124-2126 .
Aarhus University

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8a746a9278d85276b45f64f1a7d9ac01
https://pure.au.dk/portal/da/publications/commentaries-on-viewpoint-maximal-nakatpase-activity-is-upregulated-in-association-with-muscle-activity(5cc65e0a-f6be-4530-bc45-90a34b90ddaa).html