Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Martin Bollmark"'
Autor:
Dmytro Honcharenko, Kristina Druceikaite, Malgorzata Honcharenko, Martin Bollmark, Ulf Tedebark, Roger Strömberg
Publikováno v:
ACS Omega, Vol 6, Iss 1, Pp 579-593 (2020)
Externí odkaz:
https://doaj.org/article/539baf667f3e41209499fd3c9f068d24
Autor:
Kristina Karalė, Martin Bollmark, Rouven Stulz, Dmytro Honcharenko, Ulf Tedebark, Roger Strömberg
Publikováno v:
Molecules, Vol 26, Iss 22, p 6927 (2021)
2′-O-(N-(Aminoethyl)carbamoyl)methyl-modified 5-methyluridine (AECM-MeU) and 5-methylcytidine (AECM-MeC) phosphoramidites are reported for the first time and prepared in multigram quantities. The syntheses of AECM-MeU and AECM-MeC nucleosides are d
Externí odkaz:
https://doaj.org/article/567574a25e0b4173a9ab63f4adf01037
Autor:
Oswaldo Pérez, Dr. Nicolaas Schipper, Dr. Valentina Leandri, Dr. Per H. Svensson, Dr. Martin Bohlin, Dr. Thorsteinn Loftsson, Dr. Martin Bollmark
Publikováno v:
ChemistryOpen, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract In contribution to the pharmaceutical development of cyclic guanosine monophosphorothioate analogue cGMPSA as a potential active pharmaceutical ingredient (API) for the treatment of inherited retinal degenerations (IRDs), its neutral form (c
Externí odkaz:
https://doaj.org/article/fab4a2973a5340db8c26d4c87cf1fc0c
Publikováno v:
Organic Process Research & Development
Post-print
Cyclic guanosine monophosphorothioate analogue 1a is currently showing potential as a drug for the treatment of inherited retinal neurodegenerations. To support ongoing preclinical and clinical work, we have developed a diastereoselec
Cyclic guanosine monophosphorothioate analogue 1a is currently showing potential as a drug for the treatment of inherited retinal neurodegenerations. To support ongoing preclinical and clinical work, we have developed a diastereoselec
Autor:
Olivia, Luige, Kristina, Karalė, Partha Pratim, Bose, Martin, Bollmark, Ulf, Tedebark, Merita, Murtola, Roger, Strömberg
Publikováno v:
RSC advances. 12(9)
The development of Zn
Autor:
Catarina Liljeholm, Martin Bollmark, Staffan Karlsson, Christofer Fredriksson, Søren M. Andersen, Robert Berg, Henrik Toft Sørensen
Publikováno v:
Organic Process Research & Development. 18:952-959
A practical and chromatography-free multikilogram synthesis of a 3-isoxazolol containing antifibrinolytic agent, AZD6564, has been developed in eight steps and 7% overall yield starting from methyl 2-chloroisonicotinate. Highlights in the synthesis a
Autor:
Peter Schuisky, Søren M. Andersen, Fredrik Zetterberg, Martin Bollmark, Robert Ehrl, Carl-Johan Aurell, Anette Witt
Publikováno v:
Organic Process Research & Development. 17:1543-1551
Ethyl 6-chloro-5-cyano-2-methylnicotinate (4) was coupled with 4-piperidinecarboxylic acid (isonipecotic acid) in 81% yield to pyridine acid 10. An amide coupling between 10 and benzylsulfonamide (6) afforded AZD1283 (1) in 79% yield using CDI as cou
Autor:
Sean L. Kitson, Carl-Johan Aurell, Stephen J. Bell, Fredrik Zetterberg, Frans Therkelsen, Conchita Fernandez Garcia, Steve McIntyre, Søren M. Andersen, Martin Bollmark, Robert Ehrl
Publikováno v:
Organic Process Research & Development. 16:819-823
Elucidation of the mechanism of formation of two major impurities in the synthetic route towards key intermediate ethyl 5-cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 1, led directly to the development of a route with significant process im
Publikováno v:
Collection of Czechoslovak Chemical Communications. 71:820-831
Using 31P NMR spectroscopy as a tool, we investigated the condensation of H-phosphonoselenoate monoesters with a hydroxy component in the presence of various coupling agents. On this basis, synthetic protocols that eliminate or significantly suppress
Publikováno v:
Collection of Czechoslovak Chemical Communications. 71:832-841
The utility of a new type of synthetic intermediates, H-phosphonoselenoate diesters, in the preparation of potentially biologically important nucleotide analogues containing the P-Se bond, was explored by converting dinucleoside H-phosphonoselenoates