Výsledky vyhledávání - "Martin Bizet"

Akademický článek

Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.

Autor: Badri Nath Singh, Hiep Tran, Joseph Kramer, Elmira Kirichenko, Neha Changela, Fei Wang, Yaping Feng, Dibyendu Kumar, Min Tu, Jie Lan, Martin Bizet, François Fuks, Ruth Steward

Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0293894 (2024)

Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are

Externí odkaz: https://doaj.org/article/3ce50553810e4b2e8cb5a9fbd4184a4f

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Akademický článek

Methylglyoxal: a novel upstream regulator of DNA methylation

Autor: Gaurav Dube, Assia Tiamiou, Martin Bizet, Yasmine Boumahd, Imène Gasmi, Rebekah Crake, Justine Bellier, Marie-Julie Nokin, Emilie Calonne, Rachel Deplus, Tom Wissocq, Olivier Peulen, Vincent Castronovo, François Fuks, Akeila Bellahcène

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)

Abstract Background Aerobic glycolysis, also known as the Warburg effect, is predominantly upregulated in a variety of solid tumors, including breast cancer. We have previously reported that methylglyoxal (MG), a very reactive by-product of glycolysi

Externí odkaz: https://doaj.org/article/99203b58e323473ab885bd1de0fe091d

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Akademický článek

Improving Infinium MethylationEPIC data processing: re-annotation of enhancers and long noncoding RNA genes and benchmarking of normalization methods

Autor: Martin Bizet, Matthieu Defrance, Emilie Calonne, Gianluca Bontempi, Christos Sotiriou, François Fuks, Jana Jeschke

Publikováno v: Epigenetics, Vol 17, Iss 13, Pp 2434-2454 (2022)

Illumina Infinium DNA Methylation (5mC) arrays are a popular technology for low-cost, high-throughput, genome-scale measurement of 5mC distribution, especially in cancer and other complex diseases. After the success of its HumanMethylation450 array (

Externí odkaz: https://doaj.org/article/7dfb809f07564239a3fb829e113edf6a

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Akademický článek

The chromatin remodelling protein LSH/HELLS regulates the amount and distribution of DNA hydroxymethylation in the genome

Autor: Maud De Dieuleveult, Martin Bizet, Laurence Colin, Emilie Calonne, Martin Bachman, Chao Li, Irina Stancheva, Benoit Miotto, François Fuks, Rachel Deplus

Publikováno v: Epigenetics, Vol 17, Iss 4, Pp 422-443 (2022)

Ten-Eleven Translocation (TET) proteins convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) leading to a dynamic epigenetic state of DNA that can influence transcription and chromatin organization. While TET proteins interact with comple

Externí odkaz: https://doaj.org/article/5adf755568894664aea40507c9488355

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Akademický článek

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

Publikováno v: EBioMedicine, Vol 79, Iss , Pp 103985- (2022)

Summary: Background: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing a

Externí odkaz: https://doaj.org/article/b64342c7f9c945c392341ed58313d142

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Akademický článek

Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces

Externí odkaz: https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f

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Akademický článek

The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes

Autor: Yasmina Serroukh, Chunyan Gu-Trantien, Baharak Hooshiar Kashani, Matthieu Defrance, Thien-Phong Vu Manh, Abdulkader Azouz, Aurélie Detavernier, Alice Hoyois, Jishnu Das, Martin Bizet, Emeline Pollet, Tressy Tabbuso, Emilie Calonne, Klaas van Gisbergen, Marc Dalod, François Fuks, Stanislas Goriely, Arnaud Marchant

Publikováno v: eLife, Vol 7 (2018)

Cytotoxic CD4 (CD4CTX) T cells are emerging as an important component of antiviral and antitumor immunity, but the molecular basis of their development remains poorly understood. In the context of human cytomegalovirus infection, a significant propor

Externí odkaz: https://doaj.org/article/82779754636643bd9037d7babaacbad5

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Akademický článek

Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state.

Autor: Dragan Milenkovic, Wim Vanden Berghe, Céline Boby, Christine Leroux, Ken Declerck, Katarzyna Szarc vel Szic, Karen Heyninck, Kris Laukens, Martin Bizet, Matthieu Defrance, Sarah Dedeurwaerder, Emilie Calonne, Francois Fuks, Guy Haegeman, Guido R M M Haenen, Aalt Bast, Antje R Weseler

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95527 (2014)

In a recent intervention study, the daily supplementation with 200 mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the im

Externí odkaz: https://doaj.org/article/66dc8ff740ab4f338d19887c8d8c09cb

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