Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Martin Bergstrand"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 11, Pp 1577-1590 (2023)
Abstract Autologous Chimeric antigen receptor (CAR‐T) cell therapy has been highly successful in the treatment of aggressive hematological malignancies and is also being evaluated for the treatment of solid tumors as well as other therapeutic areas
Externí odkaz:
https://doaj.org/article/f43babcbc5b1492bb69bb0f82fcc856c
Autor:
Benjamin Guiastrennec, David P. Sonne, Martin Bergstrand, Tina Vilsbøll, Filip K. Knop, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 9, Pp 603-612 (2018)
Bile acids released postprandially can modify the rate and extent of lipophilic compounds’ absorption. This study aimed to predict the enterohepatic circulation (EHC) of total bile acids (TBAs) in response to caloric intake from their spillover in
Externí odkaz:
https://doaj.org/article/64b1229fb37e4ce3bcf2476ace11cf46
Autor:
Jesmin Permala Lohy Das, Myat P. Kyaw, Myat H. Nyunt, Khin Chit, Kyin H. Aye, Moe M. Aye, Mats O. Karlsson, Martin Bergstrand, Joel Tarning
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background Artemisinins are the most effective anti-malarial drugs for uncomplicated and severe Plasmodium falciparum malaria. However, widespread artemisinin resistance in the Greater Mekong Region of Southeast Asia is threatening the possi
Externí odkaz:
https://doaj.org/article/6018fefd4e4a489a8e0ef3202b43bb4b
PDF file - 143KB, Goodness-of-fit plots: (A,B) evaluation dataset with allometric body weight as covariate on clearance; (C,D) evaluation dataset with body surface area as covariate on clearance. For each dataset the observed plasma concentrations ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab74f96e94919f2b3fe8ffe9e1c8aa2
https://doi.org/10.1158/1078-0432.22444065.v1
https://doi.org/10.1158/1078-0432.22444065.v1
PDF file - 79KB, (A) Conditional weighted residuals over time after dose for the population model with allometric body weight as covariate on clearance and (B) conditional weighted residuals over time after dose for the population model with body sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb7a4b215ccbdbbbdc2207cc3f83601
https://doi.org/10.1158/1078-0432.22444071
https://doi.org/10.1158/1078-0432.22444071
PDF file - 139KB, prediction corrected Visual Predictive Checks pcVPC; (A) development models; (B) development models with IV busulfan data; (C) development models with oral busulfan data; (D) evaluation dataset; pcVPCs show the median solid black li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a057124d9cb5b258791d31802bf8e9b
https://doi.org/10.1158/1078-0432.22444068.v1
https://doi.org/10.1158/1078-0432.22444068.v1
PDF file - 75KB, Population model comparison; population parameter estimates Abbreviations: BW body weight, BSA body surface area, CL apparent clearance, V apparent volume of distribution, ka absorption rate constant, F bioavailability, standard erro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f16ef0e73cdbdedd3e909774609933a
https://doi.org/10.1158/1078-0432.22444059
https://doi.org/10.1158/1078-0432.22444059
Purpose: To evaluate the best method for dosing busulfan in children, we retrospectively analyzed two different data sets from three different dosing regimens by means of population pharmacokinetics using NONMEM.Experimental Design: The development d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14aaba1df976b3952edda5ba04119738
https://doi.org/10.1158/1078-0432.c.6520050
https://doi.org/10.1158/1078-0432.c.6520050
PDF file - 612KB, AUC exposure shown by weight groups from simulations for the (A) allometric dosing regimen and (B) BSA dosing regimen with an AUCtarget of 1150�M*min; plots the 10th, 25th, 50th median, 75th and 90th percentiles as vertical boxes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad03b67da78c2cc3ded2e14b7430dab0
https://doi.org/10.1158/1078-0432.22444062
https://doi.org/10.1158/1078-0432.22444062
Autor:
Martina Brueckmann, Lisa Bomgaars, Martin Bergstrand, Lesley G. Mitchell, Moustafa M. A. Ibrahim, Leonardo R. Brandão, Elizabeth Chalmers, Savion Gropper, Fenglei Huang, Jacqueline Halton, Matteo Luciani, Igor Tartakovsky, David Joseph, Manuela Albisetti, Daniel Röshammar
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Dabigatran etexilate (DE), a direct oral thrombin inhibitor, has been evaluated in children with venous thromboembolism (VTE) using oral solution, pellets, or capsules. Objectives This study evaluated DE pharmacokinetics (PK) in children w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6f28e48321106c7465cc0257b5e3fd
https://doi.org/10.1111/jth.15277
https://doi.org/10.1111/jth.15277