Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Martin Beinborn"'
Autor:
Kathleen M. Sicinski, Vittorio Montanari, Venkata S. Raman, Jamie R. Doyle, Benjamin N. Harwood, Yi Chi Song, Micaella P. Fagan, Maribel Rios, David R. Haines, Alan S. Kopin, Martin Beinborn, Krishna Kumar
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 454-466 (2021)
Externí odkaz:
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 823-830 (2013)
The hydroxy-carboxylic acid receptor (HCA1) is a G protein-coupled receptor that is highly expressed on adipocytes and considered a potential target for the treatment of dyslipidemia. In the current study, we investigated the pharmacological properti
Externí odkaz:
https://doaj.org/article/ddb9cf2c90a84fd2a0981d13c1201029
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24693 (2011)
BACKGROUND:The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptors are considered complementary therapeutic targets for type 2 diabetes. Using recombinant membrane-tethered ligand (MTL) technology, the
Externí odkaz:
https://doaj.org/article/24082e83afab4e08916be489cab49f4e
Autor:
Alan S. Kopin, Martin Beinborn, Micaella P Fagan, Jamie R. Doyle, David R. Haines, Maribel Rios, Kathleen M Sicinski, Venkata S. Raman, Yi Chi Song, Krishna Kumar, Vittorio Montanari, Benjamin N. Harwood
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 454-466 (2021)
ACS Central Science
ACS Central Science
The gut-derived incretin hormone, glucagon-like peptide-1 (GLP1), plays an important physiological role in attenuating post-prandial blood glucose excursions in part by amplifying pancreatic insulin secretion. Native GLP1 is rapidly degraded by the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981a6490ffab054d45057568971aa31
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:106-116
The Cys-Cys chemokine receptor 6 (CCR6) is a well-established modulator of inflammation. Although several genetic associations have been identified between CCR6 polymorphisms and immune system disorders (e.g., rheumatoid arthritis and Crohn's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf226d4f5dbd28e46392a9e3e90fe30
https://doi.org/10.1124/jpet.116.237669
https://doi.org/10.1124/jpet.116.237669
Autor:
Yuantee Zhu, Martin Beinborn, Michael N. Nitabach, Alan S. Kopin, Charles Choi, Jean-Philippe Fortin
Publikováno v:
Proceedings of the National Academy of Sciences. 106:8049-8054
Class B1 (secretin family) G protein-coupled receptors (GPCRs) modulate a wide range of physiological functions, including glucose homeostasis, feeding behavior, fat deposition, bone remodeling, and vascular contractility. Endogenous peptide ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0894d28d1de7aacb9bcdbeabc42d9761
https://doi.org/10.1073/pnas.0900149106
https://doi.org/10.1073/pnas.0900149106
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:10106-10112
To elucidate the receptor-bound conformation of glucagon-like peptide-1 (GLP-1), a series of conformationally constrained GLP-1 analogues were synthesized by introducing lactam bridges between Lys(i) and Glu(i)(+4) to form alpha-helices at various po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8a7d85b11fc78000d2550f7b216f02
https://doi.org/10.1016/j.bmc.2008.10.006
https://doi.org/10.1016/j.bmc.2008.10.006
Publikováno v:
Journal of Medicinal Chemistry. 51:7303-7307
The relative simplicity and high specificity of peptide therapeutics has fueled recent interest. However, peptide and protein drugs generally require injection and suffer from low metabolic stability. We report here the design, synthesis, and charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0c96c31648ce0d019e8fb1a21bfb44
https://doi.org/10.1021/jm8008579
https://doi.org/10.1021/jm8008579
Publikováno v:
Journal of Molecular Neuroscience. 34:211-223
Drugs targeting dopamine receptors have been the focus of much research over the past 30 years, in large part because of their role in treating multiple pathological conditions including Parkinson's disease, schizophrenia, Tourette's syndrome, and hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8537c485779a53bc896372f03da17b98
https://doi.org/10.1007/s12031-007-9030-x
https://doi.org/10.1007/s12031-007-9030-x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:1036-1043
The growth hormone secretagogue receptor (GHSR) plays an important role in regulating food intake and energy homeostasis. In this study, we compared the pharmacological properties of four reported variants of the human GHSR (I134T, V160M, A204E, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c92caa342b12beac95cb1369bbef297
https://doi.org/10.1124/jpet.107.123141
https://doi.org/10.1124/jpet.107.123141