Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Martin B. Ulmschneider"'
Autor:
David Hollingworth, Frances Thomas, Dana A. Page, Mohamed A. Fouda, Raquel Lopez-Rios De Castro, Altin Sula, Vitaliy B. Mykhaylyk, Geoff Kelly, Martin B. Ulmschneider, Peter C. Ruben, B. A. Wallace
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (INaL). INaL results from in
Externí odkaz:
https://doaj.org/article/eeabfb2a411349818eb73589abebceae
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Membrane active peptides are known to porate lipid bilayers, but their exact permeabilization mechanism and the structure of the nanoaggregates they form in membranes have often been difficult to determine experimentally. For many sequences
Externí odkaz:
https://doaj.org/article/188906633d6b4692b73fe53342f67369
Publikováno v:
ACS Omega, Vol 9, Iss 26, Pp 28715-28725 (2024)
Externí odkaz:
https://doaj.org/article/e62541fe21ba48ee9ea9ecc5bdcf4a9d
Autor:
Ayesha Khan, Richard Killick, Daniel Wirth, Dominique Hoogland, Kalina Hristova, Jakob P. Ulmschneider, Christopher R. King, Martin B. Ulmschneider
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Reducing brain levels of both soluble and insoluble forms of amyloid beta (Aβ) remains the primary goal of most therapies that target Alzheimer's disease (AD). However, no treatment has so far resulted in patient benefit, and c
Externí odkaz:
https://doaj.org/article/964ff61904ec4b6b91c1f1f545a124ba
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1100-1112 (2021)
Externí odkaz:
https://doaj.org/article/8e92cc16e1d54f4c9a7d884ffd66678c
Autor:
Charles H. Chen, Yu‐Han Liu, Arvin Eskandari, Jenisha Ghimire, Leon Chien‐Wei Lin, Zih‐Syun Fang, William C. Wimley, Jakob P. Ulmschneider, Kogularamanan Suntharalingam, Che‐Ming Jack Hu, Martin B. Ulmschneider
Publikováno v:
Advanced Science, Vol 9, Iss 13, Pp n/a-n/a (2022)
Abstract Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and induction of drug resistance via stress‐induced mu
Externí odkaz:
https://doaj.org/article/3d2758c7d56f4fad97392aa8500d523e
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transien
Externí odkaz:
https://doaj.org/article/322f5d07a3e6460aa7ea543a7dc9effb
Autor:
Charles H. Chen, Bing Zan, Jakob P. Ulmschneider, William C. Wimley, Timothy K. Lu, Martin B. Ulmschneider, Liping Zhou
Publikováno v:
Journal of Peptide Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7220178caedbdbaacdb025a50f309d17
https://doi.org/10.1002/psc.3482
https://doi.org/10.1002/psc.3482
Autor:
Jakob P. Ulmschneider, Shantanu Guha, Martin B. Ulmschneider, Charles G. Starr, William C. Wimley, Charles Chen
Publikováno v:
The Journal of Membrane Biology. 254:75-96
The use of designed antimicrobial peptides as drugs has been impeded by the absence of simple sequence-structure-function relationships and design rules. The likely cause is that many of these peptides permeabilize membranes via highly disordered, he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e21255ac658ccda7434d258300b1734
https://doi.org/10.1007/s00232-021-00174-1
https://doi.org/10.1007/s00232-021-00174-1
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2405
Understanding the interactions between peptides and lipid membranes could not only accelerate the development of antimicrobial peptides as treatments for infections but also be applied to finding targeted therapies for cancer and other diseases. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6acc5e2687d120d5d977ed99c720b0f0
https://pubmed.ncbi.nlm.nih.gov/35298811
https://pubmed.ncbi.nlm.nih.gov/35298811