Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Martin B. Brenner"'
Autor:
Yan Weng, Jeffrey R Chabot, Barbara Bernardo, Qingyun Yan, Yimin Zhu, Martin B Brenner, Chandra Vage, Alison Logan, Roberto Calle, Saswata Talukdar
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119104 (2015)
Pharmacological administration of fibroblast growth factor 21 (FGF21) improves metabolic profile in preclinical species and humans. FGF21 exerts its metabolic effects through formation of beta-klotho (KLB)/FGF receptor 1c FGFR1c complex and subsequen
Externí odkaz:
https://doaj.org/article/aed1e6d6ba284404809036ca2277d7e3
Autor:
Darwin V Lee, Dongmei Li, Qingyun Yan, Yimin Zhu, Bryan Goodwin, Roberto Calle, Martin B Brenner, Saswata Talukdar
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111767 (2014)
Fibroblast growth factor 21 (FGF21) has evolved as a major metabolic regulator, the pharmacological administration of which causes weight loss, insulin sensitivity and glucose control in rodents and humans. To understand the molecular mechanisms by w
Externí odkaz:
https://doaj.org/article/4bb2cb6254e341c3a8c89725072036b0
Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.
Autor:
Alex Gutteridge, J Michael Rukstalis, Daniel Ziemek, Mark Tié, Lin Ji, Rebeca Ramos-Zayas, Nancy A Nardone, Lisa D Norquay, Martin B Brenner, Kim Tang, John D McNeish, Rebecca K Rowntree
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56024 (2013)
We have used a previously unavailable model of pancreatic development, derived in vitro from human embryonic stem cells, to capture a time-course of gene, miRNA and histone modification levels in pancreatic endocrine cells. We investigated whether it
Externí odkaz:
https://doaj.org/article/ba50e4e5722448bd92405c4304f6ca70
Autor:
Adhiraj Lanba, Yan Weng, Veena Somayaji, Ronald W. Clark, Michelle Rossulek, Jeffrey R. Chabot, Dongmei Li, Derek M. Erion, Bryan Goodwin, Martin B. Brenner, Yingjiang Zhou, Saswata Talukdar, Bryn M. Owen, Kathryn E. Gropp, Roberto A. Calle, Timothy P. Rolph, Jennifer Q. Dong, Jeffrey K. Trimmer
Publikováno v:
Cell Metabolism. 23:427-440
FGF21 plays a central role in energy, lipid, and glucose homeostasis. To characterize the pharmacologic effects of FGF21, we administered a long-acting FGF21 analog, PF-05231023, to obese cynomolgus monkeys. PF-05231023 caused a marked decrease in fo
Autor:
Xiao Liang, Zhufang Shen, Martin B. Brenner, Bing Cui, Steven M. Watkins, Gautum K. Bandyopadhyay, Takeshi Imamura, Olivia Osborn, Jerrold M. Olefsky, Min Lu, Salvatore Iovino, Joshua Wollam, Shaocong Hou, Wei Ying, Pingping Li, Andrew M.F. Johnson, Dorothy D. Sears, Lijuan Kong, Shuainan Liu, Da Young Oh
Publikováno v:
Cell, vol 167, iss 4
In obesity, macrophages and other immune cells accumulate in insulin target tissues, promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2a01be1ab2047fe148c014ef81fed9
https://europepmc.org/articles/PMC5179329/
https://europepmc.org/articles/PMC5179329/
Autor:
Martin B. Brenner, Joseph S. Warmus, Jeffrey S. Dubins, Liuqing Wei, Janice E. Chin, Nicole S. Roush, David Hepworth, Angela Wolford, Mei Li, Sophie Y. Lavergne, Sandra M. Jennings, Wenhua Jiao, Kevin B. Bahnck, Denise Gautreau, David W. Piotrowski, Joanne Buxton, John R. Hadcock, Matthew F. Sammons, Declan Flynn, Michael Herr, Benjamin D. Stevens, Steven B. Coffey, Kentaro Futatsugi, Michael John Munchhof, Jian Wang, Terri Hinchey, Suvi T. M. Orr, Gregory Storer, Angel Guzman-Perez, Bryan Li, Ann M. Janssen
Publikováno v:
MedChemComm. 4:205-210
Reported herein is a medicinal chemistry effort towards the identification of orally available TGR5 agonist 12, which served as a dog tool compound for studies to increase confidence in this mechanism. With the challenge of striking the balance of TG
Autor:
Joseph S. Warmus, Steven B. Coffey, John R. Hadcock, Liuqing Wei, Kevin Daniel Freeman-Cook, Martin B. Brenner, Kentaro Futatsugi, Suvi T. M. Orr, Nicole S. Roush, Angela Wolford, David W. Piotrowski, David Hepworth, Joanne Buxton, Sophie Y. Lavergne, Michael Herr, Gregory Storer, Janice E. Chin, Jian Wang, Ann M. Janssen, Terri Hinchey, Raman Sharma, Allyn T. Londregan, Amit S. Kalgutkar, Sandra M. Jennings, Wenhua Jiao, Declan Flynn
Publikováno v:
ACS Medicinal Chemistry Letters. 4:63-68
Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class of high-throughput screening (HTS)-derived tetrahydropyrido[4,3-d]pyrimidine amide TGR5 ag
Autor:
Andrew Mark Vick, Niels Porksen, Yu Tian, Wolfgang Glaesner, Tom Bumol, Anja Koester, Garret J. Etgen, Krister Bokvist, Rohn Lee Millican, Bernice Ellis, Martin B. Brenner, Sheng-Hung Rainbow Tschang
Publikováno v:
Diabetes/Metabolism Research and Reviews. 26:287-296
Background Glucagon-like peptide-1 (GLP-1) receptor agonists are novel agents for type 2 diabetes treatment, offering glucose-dependent insulinotropic effects, reduced glucagonemia and a neutral bodyweight or weight-reducing profile. However, a short
Autor:
Martin B. Brenner, Gautam Bandyopadhyay, Nancy Levin, Timothy P. Rolph, Barbara Bernardo, Min Lu, Derek M. Erion, Jie Huang, Saswata Talukdar, Eva M. Tomas, Yingjiang Zhou, Pingping Li, Roberto A. Calle
Publikováno v:
Scientific Reports
FGF21 is a key metabolic regulator modulating physiological processes and its pharmacological administration improves metabolic profile in preclinical species and humans. We used native-FGF21 and a long-acting FGF21 (PF-05231023), to determine the co
Autor:
Yimin Zhu, Barbara Bernardo, Alison Logan, Chandra Vage, Saswata Talukdar, Jeffrey R. Chabot, Roberto A. Calle, Yan Weng, Qingyun Yan, Martin B. Brenner
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0119104 (2015)
PLoS ONE, Vol 10, Iss 3, p e0119104 (2015)
Pharmacological administration of fibroblast growth factor 21 (FGF21) improves metabolic profile in preclinical species and humans. FGF21 exerts its metabolic effects through formation of beta-klotho (KLB)/FGF receptor 1c FGFR1c complex and subsequen