Výsledky vyhledávání - "Martin Augistin"

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Autor: Timothy P, Heffron, Robert A, Heald, Chudi, Ndubaku, BinQing, Wei, Martin, Augistin, Steven, Do, Kyle, Edgar, Charles, Eigenbrot, Lori, Friedman, Emanuela, Gancia, Philip S, Jackson, Graham, Jones, Aleksander, Kolesnikov, Leslie B, Lee, John D, Lesnick, Cristina, Lewis, Neville, McLean, Mario, Mörtl, Jim, Nonomiya, Jodie, Pang, Steve, Price, Wei Wei, Prior, Laurent, Salphati, Steve, Sideris, Steven T, Staben, Stefan, Steinbacher, Vickie, Tsui, Jeffrey, Wallin, Deepak, Sampath, Alan G, Olivero

Publikováno v: Journal of medicinal chemistry. 59(3)

Inhibitors of the class I phosphoinositide 3-kinase (PI3K) isoform PI3Kα have received substantial attention for their potential use in cancer therapy. Despite the particular attraction of targeting PI3Kα, achieving selectivity for the inhibition o

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