Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Martin Alexander Schubert"'
1
Akademický článek
A Novel Protocol Using Small-Scale Spray-Drying for the Efficient Screening of Solid Dispersions in Early Drug Development and Formulation, as a Straight Pathway from Screening to Manufacturing Stages
Autor: Aymeric Ousset, Rosanna Chirico, Florent Robin, Martin Alexander Schubert, Pascal Somville, Kalliopi Dodou
Publikováno v: Pharmaceuticals, Vol 11, Iss 3, p 81 (2018)
This work describes a novel screening strategy that implements small-scale spray-drying in early development of binary amorphous solid dispersions (ASDs). The proposed methodology consists of a three-stage decision protocol in which small batches (20
Externí odkaz: https://doaj.org/article/d93eed9fa6314c9ba791d70283c37555
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2
Akademický článek
Prediction of Phase Behavior of Spray-Dried Amorphous Solid Dispersions: Assessment of Thermodynamic Models, Standard Screening Methods and a Novel Atomization Screening Device with Regard to Prediction Accuracy
Autor: Aymeric Ousset, Pierre-François Chavez, Joke Meeus, Florent Robin, Martin Alexander Schubert, Pascal Somville, Kalliopi Dodou
Publikováno v: Pharmaceutics, Vol 10, Iss 1, p 29 (2018)
The evaluation of drug–polymer miscibility in the early phase of drug development is essential to ensure successful amorphous solid dispersion (ASD) manufacturing. This work investigates the comparison of thermodynamic models, conventional experime
Externí odkaz: https://doaj.org/article/08f4fe6e295e4741a66f63b2c9b91918
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3
Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding
Autor: Martin Alexander Schubert, Chris Vervaet, Pierre-François Chavez, F. Stauffer, Valérie Vanhoorne, G. Pilcer, T. De Beer
Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 135:49-60
Continuous powder feeding is a critical step in continuous manufacturing of solid dosage forms, as this unit operation should ensure the mass flow consistency at the desired powder feed rate to guarantee the process throughput and final product consi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e9d10a11fa26f7494d461878445333
https://doi.org/10.1016/j.ejpb.2018.12.012
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4
Development of a small-scale spray-drying approach for amorphous\ud solid dispersions (ASDs) screening in early drug development
Autor: Florent Robin, Kalliopi Dodou, Pierre-François Chavez, Aymeric Ousset, Celine Bassand, Joke Meeus, Pascal Somville, Martin Alexander Schubert
Publikováno v: Pharmaceutical Development and Technology
The present study details the development of a small-scale spray-drying approach\ud for the routine screening of amorphous solid dispersions (ASDs). This strategy\ud aims to overcome the limitations of standard screening methodologies like\ud solvent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d976503550c0a9d5870adf143c45d2a
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5
Comparison of a Novel Miniaturized Screening Device with Büchi B290 Mini Spray-Dryer for the Development of Spray-Dried Solid Dispersions (SDSDs)
Autor: Aymeric Ousset, Joke Meeus, Pascal Somville, Florent Robin, Kalliopi Dodou, Martin Alexander Schubert
Publikováno v: Processes
Volume 6
Issue 8
Processes, Vol 6, Iss 8, p 129 (2018)
Spray-drying is an increasingly popular technology for the production of amorphous solid dispersions (ASDs) in the pharmaceutical industry that is used in the early evaluation and industrial production of formulations. Efficient screening of ASD in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e8ddd01e4ae9ea869e29517e4ba597
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6
A Novel Protocol Using Small-Scale Spray-Drying for the Efficient Screening of Solid Dispersions in Early Drug Development and Formulation, as a Straight Pathway from Screening to Manufacturing Stages
Autor: Florent Robin, Pascal Somville, Martin Alexander Schubert, Aymeric Ousset, Kalliopi Dodou, Rosanna Chirico
Publikováno v: Pharmaceuticals, Vol 11, Iss 3, p 81 (2018)
Pharmaceuticals
Volume 11
Issue 3
This work describes a novel screening strategy that implements small-scale spray-drying in early development of binary amorphous solid dispersions (ASDs). The proposed methodology consists of a three-stage decision protocol in which small batches (20
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba52f2d7614231070362cac2916cbd3
http://www.mdpi.com/1424-8247/11/3/81
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7
Prediction of Phase Behavior of Spray-Dried Amorphous Solid Dispersions: Assessment of Thermodynamic Models, Standard Screening Methods and a Novel Atomization Screening Device with Regard to Prediction Accuracy
Autor: Pierre-François Chavez, Aymeric Ousset, Joke Meeus, Pascal Somville, Kalliopi Dodou, Martin Alexander Schubert, Florent Robin
Publikováno v: Pharmaceutics
Pharmaceutics; Volume 10; Issue 1; Pages: 29
Pharmaceutics, Vol 10, Iss 1, p 29 (2018)
The evaluation of drug–polymer miscibility in the early phase of drug development is essential to ensure successful amorphous solid dispersion (ASD) manufacturing. This work investigates the comparison of thermodynamic models, conventional experime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9677da1917f0184cbbb1d99838b95335
http://europepmc.org/articles/PMC5874842
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8
Development of a predictive model for the long term stability assessment of drug-in-adhesive transdermal films using polar pressure sensitive adhesives as carrier/matrix
Autor: Martin Alexander Schubert, Clémence Chenevas-Paule, Mark Ashton, Kalliopi Dodou, Hans-Michael Wolff
Drug crystallization in transdermal drug delivery systems is a critical quality defect. The impact of drug load and hydration on the physical stability of polar (acrylic) drug-in-adhesive (DIA) films was investigated with the objective to identify pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db083f22b128e9060ff41571072a7199
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9
Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier
Autor: Kalliopi Dodou, Hans-Michael Wolff, Clémence Chenevas-Paule, Mark Ashton, Martin Alexander Schubert
Publikováno v: Journal of pharmaceutical sciences. 106(5)
Microreservoir-type transdermal drug delivery systems (MTDDS) can prevent drug crystallization; however, no current predictive model considers the impact of drug load and hydration on their physical stability. We investigated MTDDS films containing p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10655677fc303efc8954691a093fdec0
https://pubmed.ncbi.nlm.nih.gov/28163134
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10
Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool
Autor: Pierre-Yves Sacre, Charlotte De Bleye, Martin Alexander Schubert, Philippe Hubert, Eric Ziemons, Pierre-François Chavez, Jérôme Mantanus, Henri Motte, Lauranne Netchacovitch
Publikováno v: Talanta. 144
The aim of this study was to develop Near infrared (NIR) methods to determine the active content of non-coated pharmaceutical tablets manufactured from a proportional tablet formulation. These NIR methods intend to be used for the monitoring of the a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa167de4c4dc6ea3ddcf92ed2d32709a
https://pubmed.ncbi.nlm.nih.gov/26452969
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