Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Martin Akerman"'
Autor:
Alyssa D Fronk, Miguel A Manzanares, Paulina Zheng, Adam Geier, Kendall Anderson, Shaleigh Stanton, Hasan Zumrut, Sakshi Gera, Robin Munch, Vanessa Frederick, Priyanka Dhingra, Gayatri Arun, Martin Akerman
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 676-701 (2024)
Abstract Splice-switching oligonucleotides (SSOs) are antisense compounds that act directly on pre-mRNA to modulate alternative splicing (AS). This study demonstrates the value that artificial intelligence/machine learning (AI/ML) provides for the id
Externí odkaz:
https://doaj.org/article/af0776e556f747fd855724c15473a6ed
Autor:
SungHee Park, Mattia Brugiolo, Martin Akerman, Shipra Das, Laura Urbanski, Adam Geier, Anil K. Kesarwani, Martin Fan, Nathan Leclair, Kuan-Ting Lin, Leo Hu, Ian Hua, Joshy George, Senthil K. Muthuswamy, Adrian R. Krainer, Olga Anczuków
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2672-2688.e7 (2019)
Summary: Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and how it contributes to malignancy are only beginning to be unraveled. Here, we define which members of the splicing factor SR and SR-like families con
Externí odkaz:
https://doaj.org/article/f827df5d6e02402098b1b3fb0fb45114
Publikováno v:
Cell Reports, Vol 1, Iss 2, Pp 110-117 (2012)
The SR protein splicing factor SRSF1 is a potent proto-oncogene that is frequently upregulated in cancer. Here, we show that SRSF1 is a direct target of the transcription factor oncoprotein MYC. These two oncogenes are significantly coexpressed in lu
Externí odkaz:
https://doaj.org/article/9354842146bf4e3085a1443a55804a89
Autor:
Kfir Oved, Eran Eden, Martin Akerman, Roy Noy, Ron Wolchinsky, Orit Izhaki, Ester Schallmach, Adva Kubi, Naama Zabari, Jacob Schachter, Uri Alon, Yael Mandel‐Gutfreund, Michal J Besser, Yoram Reiter
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-11 (2009)
Abstract Heterogeneous cell populations form an interconnected network that determine their collective output. One example of such a heterogeneous immune population is tumor‐infiltrating lymphocytes (TILs), whose output can be measured in terms of
Externí odkaz:
https://doaj.org/article/b849521a2c414ac981b91c9ece53a2d3
Autor:
Miguel A Manzanares, Priyanka Dhingra, Kendall Anderson, Vanessa Frederick, Adam Geier, Alyssa Casill, Martin Akerman, Gayatri Arun
Publikováno v:
Cancer Research. 82:P5-17
Aberrant splicing is a major hallmark of cancer, affecting tumor progression, metastasis, and therapy resistance. The oncogenic activity of specific cis splicing errors and trans-acting splicing factor misregulation in patient tumors have been demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38f68b5cd1da81a9af96d0dfed822483
https://doi.org/10.1158/1538-7445.sabcs21-p5-17-11
https://doi.org/10.1158/1538-7445.sabcs21-p5-17-11
Autor:
Alyssa D Fronk, Miguel A Manzanares, Paulina Zheng, Adam Geier, Kendall Anderson, Vanessa Frederick, Shaleigh Smith, Sakshi Gera, Robin Munch, Mahati Are, Priyanka Dhingra, Gayatri Arun, Martin Akerman
This study demonstrates the value that artificial intelligence/machine learning (AI/ML) provides for the identification of novel and verifiable splice-switching oligonucleotide (SSO) targetsin-silico. SSOs are antisense compounds that act directly on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b9bcb7d19b234dfd363b5fc824d646
https://doi.org/10.1101/2022.10.14.512313
https://doi.org/10.1101/2022.10.14.512313
Autor:
Hasan Ekrem Zumrut, Kendall Anderson, Miguel Manzanares, Shaleigh Smith, Sakshi Gera, Nayab Habib, Sanjana Shah, Devon Trahan, Martin Akerman, Gayatri Arun
Publikováno v:
Cancer Research. 83:448-448
RNA splicing is a central step in the regulation of gene expression, leading to the accurate assembly of viable mRNA isoforms. Errors in the splicing process are common in cancer and lead to the production of tumor-specific mRNAs that often encode fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567d7d4c62878d03424a2e0a6be2cedb
https://doi.org/10.1158/1538-7445.am2023-448
https://doi.org/10.1158/1538-7445.am2023-448
Publikováno v:
Cancer Research. 80:P3-11
Splicing deregulation is a major hallmark of cancer, affecting progression, metastasis and therapy resistance. Multiple studies have demonstrated the oncogenic activity of specific splicing events and splicing factors, including SRSF1, SRSF2, ESRP1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3828e57a03122cee6f506309a62d5c3d
https://doi.org/10.1158/1538-7445.sabcs19-p3-11-21
https://doi.org/10.1158/1538-7445.sabcs19-p3-11-21
Autor:
Adrian R. Krainer, Shipra Das, Martin Fan, Nathan K. Leclair, Leo Hu, Olga Anczuków, Laura Urbanski, Adam Geier, SungHee Park, Martin Akerman, Ian Hua, Senthil K. Muthuswamy, Joshy George, Kuan-Ting Lin, Mattia Brugiolo, Anil K. Kesarwani
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2672-2688.e7 (2019)
Summary: Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and how it contributes to malignancy are only beginning to be unraveled. Here, we define which members of the splicing factor SR and SR-like families con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9c6c61db16613b4bf9fef37a973633
http://www.sciencedirect.com/science/article/pii/S2211124719314433
http://www.sciencedirect.com/science/article/pii/S2211124719314433
Autor:
Miguel A. Manzanares, Alyssa Casill, Kendall Anderson, Priyanka Dhingra, Vanessa Frederick, Adam Geier, Martin Akerman, Gayatri Arun
Publikováno v:
Cancer Research. 82:1873-1873
Accumulating evidence highlights aberrant splicing as a disease-driving event in cancer, affecting tumor progression, metastasis, and therapy resistance. Multiple studies have described the tumor-promoting activity of specific aberrant cis-splicing v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ede17216e49e0d2b8f403e6ece74891
https://doi.org/10.1158/1538-7445.am2022-1873
https://doi.org/10.1158/1538-7445.am2022-1873