Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Martin A. Wear"'
1
Akademický článek
Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach
Autor: Ashita Singh, Monikaben Padariya, Jakub Faktor, Sachin Kote, Sara Mikac, Alicja Dziadosz, Tak W. Lam, Jack Brydon, Martin A. Wear, Kathryn L. Ball, Ted Hupp, Alicja Sznarkowska, Borek Vojtesek, Umesh Kalathiya
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The interferon signalling system elicits a robust cytokine response against a wide range of environmental pathogenic and internal pathological signals, leading to induction of a subset of interferon-induced proteins. We applied DSS (disuccin
Externí odkaz: https://doaj.org/article/dde10cbfa9fa423d95fc9d4bcdeb1995
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2
Akademický článek
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
Autor: Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Glycolytic enzymes are challenging drug targets due to their highly conserved active sites and phosphorylated substrates. Here, the authors identify fast acting allosteric inhibitors of Trypanosoma brucei phosphofructokinase that block trypanosome gl
Externí odkaz: https://doaj.org/article/4b5f2d939f554cc8b893fd1148232b4e
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3
Akademický článek
Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200
Autor: Martin A. Wear, Matthew W. Nowicki, Elizabeth A. Blackburn, Iain W. McNae, Malcolm D. Walkinshaw
Publikováno v: FEBS Open Bio, Vol 7, Iss 4, Pp 533-549 (2017)
We have established a refined methodology for generating surface plasmon resonance sensor surfaces of recombinant his‐tagged human cyclophilin‐A. Our orientation‐specific stabilisation approach captures his‐tagged protein under ‘physiologic
Externí odkaz: https://doaj.org/article/2b897559d29a477eb4e1bf2d09d79cd3
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4
Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis
Autor: James Kinkead, Malcolm D. Walkinshaw, Martin A. Wear, Monserrat Vásquez-Valdivieso, Iain W. McNae, Peter M Fernandes, Paul A.M. Michels
Publikováno v: The Febs Journal
Fernandes, P, Kinkead, J, McNae, I, Vásquez-Valdivieso, M G, Wear, M, Michels, P & Walkinshaw, M 2019, ' Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis ', Febs Journal . https://doi.org/10.1111/febs.15177
Trypanosomatids possess glycosome organelles that contain much of the glycolytic machinery, including phosphofructokinase (PFK). We present kinetic and structural data for PFK from three human pathogenic trypanosomatids, illustrating intriguing diffe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0ea2f8a7ecd2ee01abc1225b75b567
http://europepmc.org/articles/PMC7383607
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5
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
Autor: James Kinkead, Ryan Ritchie, Paul A.M. Michels, Simon N. Pettit, Adrian J. Highton, Jeremy C. Mottram, Elizabeth A. Blackburn, Carol Austin, Martin Walker, Martin A. Wear, Antonio K. Vong, Malcolm D. Walkinshaw, Andrew John Keats, Scott P. Webster, Divya Malik, Nick Gray, Chris Swain, Li-Hsuan Yen, Iain W. McNae, Peter M Fernandes, Jacqueline Dornan, Elmarie Myburgh
Publikováno v: McNae, I W, Kinkead, J, Malik, D, Yen, L-H, Walker, M K, Swain, C, Webster, S P, Gray, N, Fernandes, P M, Myburgh, E, Blackburn, E A, Ritchie, R, Austin, C, Wear, M A, Highton, A J, Keats, A J, Vong, A, Dornan, J, Mottram, J C, Michels, P A M, Pettit, S & Walkinshaw, M D 2021, ' Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice ', Nature Communications, vol. 12, no. 1, 1052 . https://doi.org/10.1038/s41467-021-21273-6
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the bite of the tsetse fly where it is wholly reliant on glycolysis for the productio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799da05836121fe3900af19fdb8614ee
https://hdl.handle.net/20.500.11820/ba80df50-0eee-4cf5-92f8-bfbfbb7b3473
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6
A helminth-derived suppressor of ST2 blocks allergic responses
Autor: Zala Sekne, E. Suzanne Cohen, Georgia Perona-Wright, Matthew K. Higgins, Martin A. Wear, William F Gregory, Elizabeth C Hinchy, Adefunke Ogunkanbi, Graham Heieis, Abhishek Jamwal, Francesco Vacca, Henry J. McSorley, Holly Webster, Josquin A Nys, Caroline Chauché
Publikováno v: Vacca, F, Chauché, C, Jamwal, A, Hinchy, E C, Heieis, G, Webster, H, Ogunkanbi, A, Sekne, Z, Gregory, W F, Wear, M, Perona-Wright, G, Higgins, M K, Nys, J A, Cohen, E S & Mcsorley, H J 2020, ' A helminth-derived suppressor of ST2 blocks allergic responses ', eLIFE, vol. 9, e54017 . https://doi.org/10.7554/eLife.54017
eLife, Vol 9 (2020)
eLife
The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d50e157d7547282bee91dad218a400a
https://doi.org/10.7554/elife.54017
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8
A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine
Autor: Caroline Chauché, Martin A. Wear, Henry J. McSorley, William F. Gregory, Francesco Vacca, Josh Richards, Adefunke Ogunkanbi, Shin Li Chia
Publikováno v: Frontiers in Immunology
Chauche, C, Vacca, F, Chia, S L, Richards, J, Gregory, W F, Ogunkanbi, A, Wear, M A & McSorley, H 2020, ' A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine ', Frontiers in Immunology, vol. 11, 1363 . https://doi.org/10.3389/fimmu.2020.01363
Frontiers in Immunology, Vol 11 (2020)
1AbstractThe murine intestinal nematode Heligmosomoides polygyrus releases the H. polygyrus Alarmin Release Inhibitor (HpARI) - a protein which binds to IL-33 and to DNA, effectively tethering the cytokine in the nucleus of necrotic cells. Previous w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45b0d5ce1c33cbb8e6f1959339ab1ff
https://pubmed.ncbi.nlm.nih.gov/32695116
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9
Pilot scale production, extraction and purification of a thermostable phycocyanin from Synechocystis sp. PCC 6803
Autor: Alistair J. McCormick, Anton Puzorjov, Suleyman Mert Unal, Martin A. Wear
Publikováno v: Puzorjov, A, Ünal, M, Wear, M A & McCormick, A J 2021, ' Pilot scale production, extraction and purification of a thermostable phycocyanin from Synechocystis sp. PCC 6803 ', Bioresource technology, vol. 345, 126459 . https://doi.org/10.1016/j.biortech.2021.126459
Phycocyanin (PC) is a soluble blue pigment-protein primarily harvested from the cyanobacterium Arthrospira platensis. PC is in high demand from several industries, but its narrow stability range limits potential applications. Here, a pilot scale (120
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e23ba28407ffd0e38a246ec874925a0
https://doi.org/10.1016/j.biortech.2021.126459
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10
Evaluation of novel 3D-printed monolithic adsorbers against conventional chromatography columns for the purification of c-phycocyanin from Spirulina
Autor: Alistair J. McCormick, Martin A. Wear, Ursula Simon, Alex Zouliatis, Simone Dimartino, Livia C T Scorza
Publikováno v: Scorza, L, Simon, U, Wear, M A, Zouliatis, A, Dimartino, S & McCormick, A J 2021, ' Evaluation of novel 3D-printed monolithic adsorbers against conventional chromatography columns for the purification of c-phycocyanin from Spirulina ', Algal Research, vol. 55, 102253 . https://doi.org/10.1016/j.algal.2021.102253
Extraction and purification of high-grade phycobiliproteins is a multistep process that typically involves costly chromatographic separation techniques. 3D printing approaches and materials can now be tailored to fabricate low-cost anion exchange mon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4fe97b51df20ccd55064c84719379a
https://doi.org/10.1016/j.algal.2021.102253
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