Zobrazeno 1 - 10
of 594
pro vyhledávání: '"Martin A Nowak"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012299 (2024)
Computing the rate of evolution in spatially structured populations is difficult. A key quantity is the fixation time of a single mutant with relative reproduction rate r which invades a population of residents. We say that the fixation time is "fast
Externí odkaz:
https://doaj.org/article/1f02ec1b43d9490cbdfd978cae77cf02
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002570 (2024)
Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such tr
Externí odkaz:
https://doaj.org/article/2890d1a322b94caeb3285185535317c4
Autor:
Xiyun Zhang, Gabriela Lobinska, Michal Feldman, Eddie Dekel, Martin A Nowak, Yitzhak Pilpel, Yonatan Pauzner, Baruch Barzel, Ady Pauzner
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011608 (2023)
[This corrects the article DOI: 10.1371/journal.pcbi.1010391.].
Externí odkaz:
https://doaj.org/article/c968eff386c341aabd5e20bdbe954f85
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002214 (2023)
Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however, may lead to an evolutionary safety concern. We define evolutionary saf
Externí odkaz:
https://doaj.org/article/1a46499a5e724a7c82d03645e5741b53
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1010987 (2023)
Human interactions can take the form of social dilemmas: collectively, people fare best if all cooperate but each individual is tempted to free ride. Social dilemmas can be resolved when individuals interact repeatedly. Repetition allows them to adop
Externí odkaz:
https://doaj.org/article/4bbfe384d7f8498e8dbee2464ed1a070
Autor:
Xiyun Zhang, Gabriela Lobinska, Michal Feldman, Eddie Dekel, Martin A Nowak, Yitzhak Pilpel, Yonatan Pauzner, Baruch Barzel, Ady Pauzner
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010391 (2022)
The COVID-19 pandemic demonstrated that the process of global vaccination against a novel virus can be a prolonged one. Social distancing measures, that are initially adopted to control the pandemic, are gradually relaxed as vaccination progresses an
Externí odkaz:
https://doaj.org/article/f47adbc2c59047de8d58f8bd94e44b50
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010149 (2022)
In repeated interactions, players can use strategies that respond to the outcome of previous rounds. Much of the existing literature on direct reciprocity assumes that all competing individuals use the same strategy space. Here, we study both learnin
Externí odkaz:
https://doaj.org/article/5fe220d873664d77bee168e116575ff6
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008402 (2020)
Resources are rarely distributed uniformly within a population. Heterogeneity in the concentration of a drug, the quality of breeding sites, or wealth can all affect evolutionary dynamics. In this study, we represent a collection of properties affect
Externí odkaz:
https://doaj.org/article/190a6522d4654e348d53acd8014f814b
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 7, p e1008010 (2020)
Antibiotic-resistant infections are a growing threat to human health, but basic features of the eco-evolutionary dynamics remain unexplained. Most prominently, there is no clear mechanism for the long-term coexistence of both drug-sensitive and resis
Externí odkaz:
https://doaj.org/article/fc95eaf5a19a45b8b373f827e6dfd83f
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007494 (2020)
The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of a
Externí odkaz:
https://doaj.org/article/9d922acf2dbb4090ad945c8ea2f1b8c5