Zobrazeno 1 - 10
of 380
pro vyhledávání: '"Martin A Kohli"'
Autor:
Johannes M Hennings, Martin A Kohli, Darina Czamara, Maria Giese, Anne Eckert, Christiane Wolf, Angela Heck, Katharina Domschke, Volker Arolt, Bernhard T Baune, Sonja Horstmann, Tanja Brückl, Torsten Klengel, Andreas Menke, Bertram Müller-Myhsok, Marcus Ising, Manfred Uhr, Susanne Lucae
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64947 (2013)
BackgroundData from clinical studies and results from animal models suggest an involvement of the neurotrophin system in the pathology of depression and antidepressant treatment response. Genetic variations within the genes coding for the brain-deriv
Externí odkaz:
https://doaj.org/article/d7ff4fab0c1d4b77b1f4b26aa8948ea8
Autor:
Marcus Ising, Johannes M. Hennings, Florian Holsboer, Susanne Lucae, Martin A. Kohli, Manfred Uhr
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 95
Major depression is a stress-related disorder with robust clinical and preclinical data implicating that both, dysregulation of the hypothalamus-pituitary-adrenocortical (HPA) axis and of the neurotrophin system of the brain are involved in the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d97eadc7cc904b3eb8dad967ead3b5e
https://pubmed.ncbi.nlm.nih.gov/31295515
https://pubmed.ncbi.nlm.nih.gov/31295515
Autor:
Martin A. Kohli, Patrice L. Whitehead, Deborah C. Mash, Crystal Humphries, Margaret A. Pericak-Vance, Lubov Nathanson, Gary W. Beecham, John R. Gilbert, Eden R. Martin
Publikováno v:
Journal of Alzheimer's Disease. 44:977-987
Previous transcriptome studies observed disrupted cellular processes in late-onset Alzheimer's disease (LOAD), yet it is unclear whether these changes are specific to LOAD, or are common to general neurodegeneration. In this study, we address this qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9ec6ad136472dbc9cd0a561afbebe0
https://doi.org/10.3233/jad-141989
https://doi.org/10.3233/jad-141989
Autor:
Martin A. Kohli, Crystal Humphries
Publikováno v:
Current Genetic Medicine Reports. 2:75-84
Alzheimer disease (AD) is the most common dementia in the elderly, still without effective treatment. Early-onset AD (EOAD) is caused by mutations in the genes APP, PSEN1 and PSEN2. Genome-wide association studies have identified >20 late-onset AD (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3c0dbc2958a85122d3560998b6e205
https://doi.org/10.1007/s40142-014-0035-9
https://doi.org/10.1007/s40142-014-0035-9
Autor:
Jeffery M. Vance, Goldie S. Byrd, Kara L. Hamilton-Nelson, Rosalyn Lang, Margaret A. Pericak-Vance, Brian W. Kunkle, Adam C. Naj, Patrice L. Whitehead, J. R. Gilbert, Eden R. Martin, Liyong Wang, Regina M. Carney, Martin A. Kohli, Jonathan L. Haines, Michael L. Cuccaro, Gary W. Beecham
Publikováno v:
Neuroscience letters. 649
Several variants in the gene ABCA7 have been identified as potential causal variants for late-onset Alzheimer’s disease (LOAD). In order to replicate these findings, and search for novel causal variants, we performed targeted sequencing of this gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f31792c23bd875796e61bf9eb9139af
https://pubmed.ncbi.nlm.nih.gov/28400126
https://pubmed.ncbi.nlm.nih.gov/28400126
Autor:
T. Dose, Thomas Bettecken, Stephan Ripke, Florian Holsboer, Susanne Lucae, Peter McGuffin, Elisabeth B. Binder, Daria Salyakina, Benno Pütz, Simone Reppermund, Torsten Klengel, Martin A. Kohli, Johannes M. Hennings, Marcus Ising, Roy H. Perlis, Steven P. Hamilton, Josef Zihl, Rudolf Uher, Tanja Brückl, Paul G. Unschuld, Bertram Müller-Myhsok, Manfred Uhr, Stefan Kloiber
Publikováno v:
European Neuropsychopharmacology. 23:653-662
Leptin, a peptide hormone from adipose tissue and key player in weight regulation, has been suggested to be involved in sleep and cognition and to exert antidepressant-like effects, presumably via its action on the HPA-axis and hippocampal function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccba059b850ea2bde7527ff2ca125d7
https://doi.org/10.1016/j.euroneuro.2012.08.010
https://doi.org/10.1016/j.euroneuro.2012.08.010
Autor:
John R. Gilbert, Martin A. Kohli, Brian W. Kunkle, Adam C. Naj, Stephan Züchner, Margaret A. Pericak-Vance, Regina M. Carney
Publikováno v:
Alzheimer's & Dementia. 10:360-365
Background The Arg406Trp (R406W) missense mutation in the microtubule-associated protein-tau gene (MAPT ) is a known cause of early-onset dementia. Various dementia phenotypes have been described, including frontotemporal dementia (FTD), FTD with par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de70d1996493a796ffe9a674694cbf5f
https://doi.org/10.1016/j.jalz.2013.02.011
https://doi.org/10.1016/j.jalz.2013.02.011
Autor:
Goldie S. Byrd, Gerard D. Schellenberg, Brian W. Kunkle, Jeffery M. Vance, Derek M. Dykxhoorn, Margaret A. Pericak-Vance, Martin A. Kohli, Badri N. Vardarajan, Holly N. Cukier, Gary W. Beecham, Jonathan L. Haines, Eden R. Martin, Michael L. Cuccaro, Regina M. Carney, Richard Mayeux, John R. Gilbert, Lindsay A. Farrer, Derek J. Van Booven, Kara L. Hamilton-Nelson, Rosalyn Lang, Sophie Rolati, Patrice L. Whitehead
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3806cd98378949bba075f6be063e17be
https://doi.org/10.1016/j.jalz.2016.06.305
https://doi.org/10.1016/j.jalz.2016.06.305
Autor:
Jeffery M. Vance, Derek J. Van Booven, Lindsay A. Farrer, Margaret A. Pericak-Vance, Brian W. Kunkle, Gerard D. Schellenberg, Holly N. Cukier, Sophie Rolati, Kara L. Hamilton-Nelson, Derek M. Dykxhoorn, Rosalyn Lang, Patrice L. Whitehead, Beth A. Dombroski, Richard Mayeux, Jonathan L. Haines, Eden R. Martin, John R. Gilbert, Regina M. Carney, Goldie S. Byrd, Michael L. Cuccaro, Martin A. Kohli, Badri N. Vardarajan, Gary W. Beecham
Publikováno v:
Neurology: Genetics
Objective: To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A ( ABC1 ), member 7 ( ABCA7 ) gene, a known risk factor for late-onset AD. Methods: Custom c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c104e978f2b33c55ca06b8f6b5052f7c
http://europepmc.org/articles/PMC4871806
http://europepmc.org/articles/PMC4871806
Autor:
Angela Heck, Andreas Menke, Philipp G. Sämann, Michael Czisch, Martin A. Kohli, Stefan Kloiber, Elisabeth B. Binder, Bertram Müller-Myhsok, Darina Czamara, Johannes M. Hennings, Susanne Lucae, Florian Holsboer
Publikováno v:
Psychoneuroendocrinology. 37:565-575
Summary Objectives Glutamate has been implicated in the pathophysiology and treatment of mood disorders possibly by affecting the regulation of the hypothalamus–pituitary–adrenocortical (HPA) axis. Growing evidence suggests an important role of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0c7339431ba22b4defd4ca29a59bfc
https://doi.org/10.1016/j.psyneuen.2011.09.003
https://doi.org/10.1016/j.psyneuen.2011.09.003