Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: A multicentre cohort follow-up study.

Autor: Mark J Hamilton, Yvonne Robb, Sarah Cumming, Helen Gregory, Alexis Duncan, Monika Rahman, Anne McKeown, Catherine McWilliam, John Dean, Alison Wilcox, Maria E Farrugia, Anneli Cooper, Josephine McGhie, Berit Adam, Richard Petty, Scottish Myotonic Dystrophy Consortium, Cheryl Longman, Iain Findlay, Alan Japp, Darren G Monckton, Martin A Denvir

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174166 (2017)

ObjectiveHigh sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor of cardiac events in a variety of settings. We have explored its utility in patients with myotonic dystrophy type 1 (DM1).Methods117 patients with DM1 were r

Externí odkaz: https://doaj.org/article/d5d3a07f0d044a9eaff8ffc4d1e835f1

Influence of Androgen Receptor in Vascular Cells on Reperfusion following Hindlimb Ischaemia.

Autor: Junxi Wu, Patrick W F Hadoke, Kaloyan Takov, Agnieszka Korczak, Martin A Denvir, Lee B Smith

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154987 (2016)

AIMS:Studies in global androgen receptor knockout (G-ARKO) and orchidectomised mice suggest that androgen accelerates reperfusion of the ischaemic hindlimb by stimulating angiogenesis. This investigation used novel, vascular cell-specific ARKO mice t

Externí odkaz: https://doaj.org/article/36d2e0e86de94933905fe03e513027e2

Identifying acute coronary syndrome patients approaching end-of-life.

Autor: Stephen Fenning, Rebecca Woolcock, Kristin Haga, Javaid Iqbal, Keith A Fox, Scott A Murray, Martin A Denvir

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35536 (2012)

BackgroundAcute coronary syndrome (ACS) is common in patients approaching the end-of-life (EoL), but these patients rarely receive palliative care. We compared the utility of a palliative care prognostic tool (Gold Standards Framework (GSF)) and the

Externí odkaz: https://doaj.org/article/575fd1b6f1414f1a9cc450526c2f91e7

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

Autor: Hon-Chiu Eastwood Leung, Gianfranco Matrone, Antrix Jain, Martin A. Denvir, John P. Cooke, Julie Rodor, Cristian Coarfa, Sung Yun Jung, Jong Min Choi, Kimal Rajapakshe, Andy Baker

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Matrone, G, Jung, S Y, Choi, J M, Jain, A, Eastwood Leung, H-C, Rajapakshe, K, Coarfa, C, Rodor, J, Denvir, M A, Baker, A H & Cooke, J P 2021, ' Nuclear S-nitrosylation impacts tissue regeneration in zebrafish ', Nature Communications . https://doi.org/10.1038/s41467-021-26621-0

Despite the importance of nitric oxide signaling in multiple biological processes, its role in tissue regeneration remains largely unexplored. Here, we provide evidence that inducible nitric oxide synthase (iNos) translocates to the nucleus during ze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89522bea17de6a4bf80d341b7eda9310
https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23

29 Predicting Unplanned Readmission and Death After Hospital Discharge: How Do Frailty Tools Compare to Electronic Health Record Frailty Markers?

Autor: Nicholas L. Mills, Susan D. Shenkin, P Keeling, Alasdair M.J. MacLullich, Martin A. Denvir, Yong Yong Tew, Atul Anand, J Hao Chan

Publikováno v: Age and Ageing. 50:i7-i11

Introduction Numerous frailty tools and definitions have been described. Amongst hospitalised patients, the validity of face-to-face instruments may be confounded by acute illness. However, patient assessment after recovery at the point of hospital d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e989e493957b0e91e8a807cb7a1bc8dd
https://doi.org/10.1093/ageing/afab029.08