Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction

Autor: Atul Anand, Sarah Cudmore, Shirley Robertson, Jacqueline Stephen, Kristin Haga, Christopher J. Weir, Scott A. Murray, Kirsty Boyd, Julian Gunn, Javaid Iqbal, Alasdair MacLullich, Susan D. Shenkin, Keith A. A. Fox, Nicholas Mills, Martin A. Denvir

Publikováno v: BMC Geriatrics, Vol 20, Iss 1, Pp 1-9 (2020)

Abstract Background Risk prediction after myocardial infarction is often complex in older patients. The Global Registry of Acute Coronary Events (GRACE) model includes clinical parameters and age, but not frailty. We hypothesised that frailty would e

Externí odkaz: https://doaj.org/article/c24c63c1ac694632a07fa3531b0c5715

Adaptive prospective optical gating enables day-long 3D time-lapse imaging of the beating embryonic zebrafish heart

Autor: Jonathan M. Taylor, Carl J. Nelson, Finnius A. Bruton, Aryan Kaveh, Charlotte Buckley, Carl S. Tucker, Adriano G. Rossi, John J. Mullins, Martin A. Denvir

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Imaging heart development is challenging due to constant tissue movement and changing physical landmarks. Here the authors present an algorithm capable of maintaining phase-locked imaging throughout a 24 hour timespan, enabling long term timelapse im

Externí odkaz: https://doaj.org/article/178169f074c049959cd3251b5dd86533

Chest pain presentations to hospital during the COVID-19 lockdown: Lessons for public health media campaigns.

Autor: Amy V Ferry, Collette Keanie, Martin A Denvir, Nicholas L Mills, Fiona E Strachan

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0249389 (2021)

ObjectiveEmergency Department (ED) attendances with chest pain reduced during the COVID-19 lockdown. We performed a service evaluation project in NHS Lothian to explore how and why the COVID-19 pandemic and public health advice had affected chest pai

Externí odkaz: https://doaj.org/article/931f69115b2e43dd95a9ac2db219d6e3

Criteria for Referral of Patients With Advanced Heart Failure for Specialized Palliative Care

Autor: Yuchieh Kathryn Chang, Larry A. Allen, John A. McClung, Martin A. Denvir, Jennifer Philip, Masanori Mori, Pedro Perez-Cruz, Shao-Yi Cheng, Anna Collins, David Hui

Publikováno v: Chang, Y K, Allen, L A, McClung, J A, Denvir, M A, Philip, J, Mori, M, Perez-Cruz, P, Cheng, S-Y, Collins, A & Hui, D 2022, ' Criteria for Referral of Patients With Advanced Heart Failure for Specialized Palliative Care ', Journal of the American College of Cardiology, vol. 80, no. 4, pp. 332-344 . https://doi.org/10.1016/j.jacc.2022.04.057

Background: Patients with advanced heart failure have substantial supportive care needs. Specialist palliative care can be beneficial, but it is unclear who is most appropriate for referral and when patients should be referred. Objectives: We conduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1d63ccfc8272c09afe1b0d99c22e16
https://doi.org/10.1016/j.jacc.2022.04.057

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

Autor: Hon-Chiu Eastwood Leung, Gianfranco Matrone, Antrix Jain, Martin A. Denvir, John P. Cooke, Julie Rodor, Cristian Coarfa, Sung Yun Jung, Jong Min Choi, Kimal Rajapakshe, Andy Baker

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Matrone, G, Jung, S Y, Choi, J M, Jain, A, Eastwood Leung, H-C, Rajapakshe, K, Coarfa, C, Rodor, J, Denvir, M A, Baker, A H & Cooke, J P 2021, ' Nuclear S-nitrosylation impacts tissue regeneration in zebrafish ', Nature Communications . https://doi.org/10.1038/s41467-021-26621-0

Despite the importance of nitric oxide signaling in multiple biological processes, its role in tissue regeneration remains largely unexplored. Here, we provide evidence that inducible nitric oxide synthase (iNos) translocates to the nucleus during ze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89522bea17de6a4bf80d341b7eda9310
https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23