Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Martin A Bewley"'
Autor:
Bartłomiej Salamaga, Tomasz K Prajsnar, Ana Jareño-Martinez, Joost Willemse, Martin A Bewley, Françoise Chau, Tassadit Ben Belkacem, Annemarie H Meijer, David H Dockrell, Stephen A Renshaw, Stéphane Mesnage
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006526 (2017)
Enterococcus faecalis is an opportunistic pathogen frequently isolated in clinical settings. This organism is intrinsically resistant to several clinically relevant antibiotics and can transfer resistance to other pathogens. Although E. faecalis has
Externí odkaz:
https://doaj.org/article/1a742257308e47bd9748ea7d865fdd1d
Autor:
Martin A Bewley, Kylie B R Belchamber, Kirandeep K Chana, Richard C Budd, Gavin Donaldson, Jadwiga A Wedzicha, Christopher E Brightling, Iain Kilty, Louise E Donnelly, Peter J Barnes, Dave Singh, Moira K B Whyte, David H Dockrell, COPDMAP
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163139 (2016)
Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecul
Externí odkaz:
https://doaj.org/article/93b4546360fc4a8381bc77a1fb98b2dd
Autor:
Marc Daigneault, Thushan I De Silva, Martin A Bewley, Julie A Preston, Helen M Marriott, Andrea M Mitchell, Timothy J Mitchell, Robert C Read, Moira K B Whyte, David H Dockrell
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002814 (2012)
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incomplete
Externí odkaz:
https://doaj.org/article/43f5810c5b064f1c963861ddb7bc27cf
Autor:
Martin A Bewley, Helen M Marriott, Calogero Tulone, Sheila E Francis, Timothy J Mitchell, Robert C Read, Benny Chain, Guido Kroemer, Moira K B Whyte, David H Dockrell
Publikováno v:
PLoS Pathogens, Vol 7, Iss 1, p e1001262 (2011)
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of a
Externí odkaz:
https://doaj.org/article/098ec9f941f241339c263c49479fd2ad
Autor:
Patrícia Coelho, Pranvera Sadiku, Alex von Kriegsheim, Leila Reyes, David H. Dockrell, Robert Grecian, Jordi Duran, Christopher J Graham, Simone Arienti, Abel Acosta-Sanchez, Veronica M. Dardé, Privjyot Jheeta, Ananda S. Mirchandani, Gordon G. Paterson, A. A. Roger Thompson, David Sammut, Tyler Morrison, Martin A. Bewley, Ailing Zhang, Joseph A Willson, Massimiliano Mazzone, Kenneth Baillie, Moira K. B. Whyte, Tobias Griessler, Sarah R. Walmsley, Emily R. Watts, Peter Carmeliet, Jessie-May Morgan, Eilise M. Ryan, John P. Thomson, Manuel A. Sanchez Garcia, Bart Ghesquière, Joan J. Guinovart, Richard R. Meehan, Gio Rodriguez-Blanco, Jason M. Young
Publikováno v:
Sadiku, P, Willson, J A, Ryan, E M, Sammut, D, Coelho, P, Watts, E R, Grecian, R, Young, J M, Bewley, M, Arienti, S, Mirchandani, A S, Sanchez Garcia, M A, Morrison, T, Zhang, A, Reyes, L, Griessler, T, Jheeta, P, Paterson, G G, Graham, C J, Thompson, J P, Baillie, K, Thompson, A A R, Morgan, J-M, Acosta-Sanchez, A, Dardé, V M, Duran, J, Guinovart, J J, Rodriguez-Blanco, G, Von Kriegsheim, A, Meehan, R R, Mazzone, M, Dockrell, D H, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2021, ' Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis ', Cell Metabolism, vol. 33, no. 2, pp. 411-423.e4 . https://doi.org/10.1016/j.cmet.2020.11.016
Cell Metabolism
Cell Metabolism
Summary Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad74cc910e5a97db33fae4b7012689
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
Autor:
David H. Dockrell, J Callahan, Joby Cole, Patrícia Coelho, JB McCafferty, Dave Singh, Richard C. Budd, Martin A. Bewley, MK Whyte, Sarah R. Walmsley, Eilise M. Ryan
Publikováno v:
BTS/BALR/BLF Early Career Investigator Awards.
COPD is set to become the third leading cause of death globally by 2023. To date, we have no significant disease modifying therapies. COPD patients experience chronic inflammation and defective innate immunity, largely driven by macrophage dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::347e4a81eea2f302f7bc071dfd7ce932
https://doi.org/10.1136/thorax-2020-btsabstracts.1
https://doi.org/10.1136/thorax-2020-btsabstracts.1
Autor:
Linda J Kay, Helen M. Marriott, Martin A. Bewley, Yiwen Yao, Sharonjit K Gill, Peter T. Peachell
Publikováno v:
British Journal of Pharmacology. 173:3099-3109
Background and Purpose PGE2 inhibits cytokine generation from human lung macrophages. However, the EP receptor that mediates this beneficial anti-inflammatory effect of PGE2 has not been defined. The aim of this study was to identify the EP receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c26d53d9baf125a6ec9926e297f0c64
https://doi.org/10.1111/bph.13565
https://doi.org/10.1111/bph.13565
Autor:
Iain Kilty, Dave Singh, Eilise M. Ryan, Ppeter J. Barnes, Gussie Beech, Richard D. Emes, Irina Tcherniaeva, Louise E. Donnelly, Sarah R. Walmsley, Moira K. B. Whyte, Jadwiga A. Wedzicha, Martin A. Bewley, Umme Kolsum, Joby Cole, Jennifer L. Marshall, William L. Rumsey, Richard C. Budd, Yolanda Sanchez, Christopher E. Brightling, Gavin C. Donaldson, Gguy A.M. Berbers, David H. Dockrell, Paul Collini
Publikováno v:
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C E, Donnelly, L E, Barnes, P J, Singh, D & Whyte, M K B & Dockrell, D H 2018, ' Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists ', American Journal of Respiratory and Critical Care Medicine, vol. 198, no. 6, pp. 739-750 . https://doi.org/10.1164/rccm.201705-0903OC
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B & Dockrell, D H 2018, ' Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201705-0903OC
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B & Dockrell, D H 2018, ' Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201705-0903OC
Rationale: Previous studies have identified defects in bacterial phagocytosis by alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD), but the mechanisms and clinical consequences remain incompletely defined.Object
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ede7f3b1e46ae120abd9a1e44f2fc73
https://www.pure.ed.ac.uk/ws/files/67945656/AJRCCM_Online_Sup_TEXT_SUB.docx
https://www.pure.ed.ac.uk/ws/files/67945656/AJRCCM_Online_Sup_TEXT_SUB.docx
Autor:
Simon A. Johnston, David H. Dockrell, Helen M. Marriott, Simon Stoneham, Robert C. Read, Simon J. Foster, Andrew A. Peden, Jamil Jubrail, Paul Morris, Martin A. Bewley
Publikováno v:
Cellular Microbiology
Summary Macrophages are critical effectors of the early innate response to bacteria in tissues. Phagocytosis and killing of bacteria are interrelated functions essential for bacterial clearance but the rate‐limiting step when macrophages are challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd0eb5f5113c9834c4277674e777056
http://europepmc.org/articles/PMC4778410
http://europepmc.org/articles/PMC4778410
Autor:
David H. Dockrell, Richard C. Budd, PA Reid, G Choudhury, Eilise M. Ryan, William L. Rumsey, Yolanda Sanchez, Patrícia Coelho, Sarah R. Walmsley, Martin A. Bewley, MK Whyte
Publikováno v:
Mechanistic insights into COPD.
COPD patients have defective innate immunity, characterised in part by macrophage dysfunction. In established disease, both monocyte derived macrophages (MDM) and alveolar macrophages (AM), have impaired phagocytosis of bacteria and apoptotic cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4582d3fb01b6fb28b3917d06071874f4
https://doi.org/10.1136/thoraxjnl-2017-210983.121
https://doi.org/10.1136/thoraxjnl-2017-210983.121