Zobrazeno 1 - 10
of 651
pro vyhledávání: '"Martin A, Schwartz"'
Autor:
Sorosh Amiri, Camelia Muresan, Xingbo Shang, Clotilde Huet-Calderwood, Martin A. Schwartz, David A. Calderwood, Michael Murrell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of the cell, from cell division to cell migration. However,
Externí odkaz:
https://doaj.org/article/ce14d1660c824adbb36e86e71d1ace82
Autor:
Kuheli Banerjee, Yanzhu Lin, Johannes Gahn, Julio Cordero, Purnima Gupta, Islam Mohamed, Mariona Graupera, Gergana Dobreva, Martin A. Schwartz, Roxana Ola
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Vascular networks form, remodel, and mature under the influence of both fluid shear stress (FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via synergy with bone morphogenic proteins 9 and 10 (BMP9 and BMP10). Co
Externí odkaz:
https://doaj.org/article/b542650ec401437cb3c92d2af512b770
Autor:
Benton A. Emblom, Brian L. Walters, Logan E. Mast, David P. Beason, John A. Ruder, Michael K. Ryan, Stephen A. Gould, Martin L. Schwartz
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/e5a80aeead4b49e8bc5828504fb0ac39
Autor:
Jeremy A. Herrera, Lewis Dingle, M. Angeles Montero, Rajamiyer V. Venkateswaran, John F. Blaikley, Craig Lawless, Martin A. Schwartz
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Usual interstitial pneumonia (UIP) is a histological pattern characteristic of idiopathic pulmonary fibrosis (IPF). The UIP pattern is patchy with histologically normal lung adjacent to dense fibrotic tissue. At this interface, fibroblastic foci (FF)
Externí odkaz:
https://doaj.org/article/da6ce78e6e224d07974ead382256b1a5
Autor:
Hanqiang Deng, Martin A. Schwartz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 14 (2022)
Background Atherosclerosis occurs preferentially in regions of low and disturbed fluid shear stress (FSS) but is limited in regions of high laminar FSS as a result of inhibition of endothelial inflammatory pathways. Recent work has identified endothe
Externí odkaz:
https://doaj.org/article/e819c259d9f243b3a7c26cbc233c9929
Autor:
Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W. Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J. Lovoulos, Martin A. Schwartz, Jay D. Humphrey, George Tellides
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Aortic dissection and rupture are triggered by decreased vascular wall strength and/or increased mechanical loads. We investigated the role of mTOR signaling in aortopathy using a well-described model of angiotensin II–induced dissection, aneurysm,
Externí odkaz:
https://doaj.org/article/6514c0bd7b9245d6a91075f917c40b3b
Autor:
Cristina Cavinato, Minghao Chen, Dar Weiss, Maria Jesús Ruiz-Rodríguez, Martin A. Schwartz, Jay D. Humphrey
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief among them mutations to the gene that encodes fibrillin-1 and leads to Marfan syndrome. Fibrillin-1 microfibrils associate with elastin to form elastic fiber
Externí odkaz:
https://doaj.org/article/da44a394911644a0abaa1aa38cf268d0
Publikováno v:
Cells, Vol 11, Iss 22, p 3584 (2022)
The function of the integrin family of receptors as central mediators of cell-extracellular matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and influences. Integrins must be anchored to the cytoskeleton and bou
Externí odkaz:
https://doaj.org/article/b059d80f1a4046fbbe8ca33142dbedf7
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Background Adhesion of vascular endothelial cells to the underlying basement membrane potently modulates endothelial cells to cells' inflammatory activation. The normal basement membrane proteins laminin and collagen IV attenuate inflammatory signali
Externí odkaz:
https://doaj.org/article/b9d7f4d104a34a08b1afa1ccf92c1123
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Blood vessel acquisition of arterial or venous fate is an adaptive phenomenon in response to increasing blood circulation during vascular morphogenesis. The past two decades of effort in this field led to development of a widely accepted paradigm of
Externí odkaz:
https://doaj.org/article/7632b94fce774742a272e60b78786319