Zobrazeno 1 - 10
of 594
pro vyhledávání: '"Martin A, Nowak"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012299 (2024)
Computing the rate of evolution in spatially structured populations is difficult. A key quantity is the fixation time of a single mutant with relative reproduction rate r which invades a population of residents. We say that the fixation time is "fast
Externí odkaz:
https://doaj.org/article/1f02ec1b43d9490cbdfd978cae77cf02
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002570 (2024)
Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such tr
Externí odkaz:
https://doaj.org/article/2890d1a322b94caeb3285185535317c4
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Many human interactions feature the characteristics of social dilemmas where individual actions have consequences for the group and the environment. The feedback between behavior and environment can be studied with the framework of stochasti
Externí odkaz:
https://doaj.org/article/e28396a4eb8746ce9da483c005777d8d
Autor:
Xiyun Zhang, Gabriela Lobinska, Michal Feldman, Eddie Dekel, Martin A Nowak, Yitzhak Pilpel, Yonatan Pauzner, Baruch Barzel, Ady Pauzner
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011608 (2023)
[This corrects the article DOI: 10.1371/journal.pcbi.1010391.].
Externí odkaz:
https://doaj.org/article/c968eff386c341aabd5e20bdbe954f85
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002214 (2023)
Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however, may lead to an evolutionary safety concern. We define evolutionary saf
Externí odkaz:
https://doaj.org/article/1a46499a5e724a7c82d03645e5741b53
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1010987 (2023)
Human interactions can take the form of social dilemmas: collectively, people fare best if all cooperate but each individual is tempted to free ride. Social dilemmas can be resolved when individuals interact repeatedly. Repetition allows them to adop
Externí odkaz:
https://doaj.org/article/4bbfe384d7f8498e8dbee2464ed1a070
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In many instances of reciprocity, individuals cooperate in turns. Here, the authors analyze the equilibria and the dynamics of such alternating games, and in particular describe all strategies with one-round memory that maintain cooperation.
Externí odkaz:
https://doaj.org/article/3bd37842c4d647739a90494487d3c533
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Motivated by COVID-19, we develop and analyze a simple stochastic model for the spread of disease in human population. We track how the number of infected and critically ill people develops over time in order to estimate the demand that is i
Externí odkaz:
https://doaj.org/article/3c1abcb0892249d59691976ba81de89f
Autor:
Martin A. Nowak, Sarah Coakley
According to the reigning competition-driven model of evolution, selfish behaviors that maximize an organism's reproductive potential offer a fitness advantage over self-sacrificing behaviors—rendering unselfish behavior for the sake of others a my
Autor:
Xiyun Zhang, Gabriela Lobinska, Michal Feldman, Eddie Dekel, Martin A Nowak, Yitzhak Pilpel, Yonatan Pauzner, Baruch Barzel, Ady Pauzner
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010391 (2022)
The COVID-19 pandemic demonstrated that the process of global vaccination against a novel virus can be a prolonged one. Social distancing measures, that are initially adopted to control the pandemic, are gradually relaxed as vaccination progresses an
Externí odkaz:
https://doaj.org/article/f47adbc2c59047de8d58f8bd94e44b50