Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Martin A, Giedlin"'
Autor:
Richard D. Schulick, Drew M. Pardoll, Thomas W. Dubensky, David N. Cook, Jill E. Slansky, Meredith L. Leong, Keith S. Bahjat, Martin A. Giedlin, Dirk G. Brockstedt, Sowmya Ravi, Christina Y. Chia, Lindsay S. Laird, Heather E. Allen, Ajay Jain, Kiyoshi Yoshimura
Improved immunization and ex vivo T-cell culture strategies can generate larger numbers and more potent tumor-specific effector cells than previously possible. Nonetheless, the capacity of these cells to eliminate established tumors is limited by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb7d48a9d38fbba96196cfc94730119
https://doi.org/10.1158/0008-5472.c.6494138
https://doi.org/10.1158/0008-5472.c.6494138
Autor:
Richard D. Schulick, Drew M. Pardoll, Thomas W. Dubensky, David N. Cook, Jill E. Slansky, Meredith L. Leong, Keith S. Bahjat, Martin A. Giedlin, Dirk G. Brockstedt, Sowmya Ravi, Christina Y. Chia, Lindsay S. Laird, Heather E. Allen, Ajay Jain, Kiyoshi Yoshimura
Supplementary Data 1-2 from Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089e76f1d441452b70f9ee177a84f04
https://doi.org/10.1158/0008-5472.22364327.v1
https://doi.org/10.1158/0008-5472.22364327.v1
Autor:
Rupert Handgretinger, Andreas Niethammer, Darrell R. Galloway, Edward Barker, Alice L. Yu, Ursula Pertl, Martin A. Giedlin, Barry D. Kahan, Soldano Ferrone, Jürgen C. Becker, Martin Schrappe, Vito Quaranta, Argyrios Theophilopoulos, Hans Loibner, Rong Xiang, Carlo Russo, Gregor Schulz, Thomas F. Bumol, Nissi Varki, Debbie Liao, Michele Pellegrino, John R. Harper, Helen Sabzevari, Ruth Ladenstein, He Zhou, Leslie E. Walker, Kohzoh Imai, Paul M. Sondel, Bill Church, Andreas Stahl, Barry S. Wilson, David A. Cheresh, Barbara M. Mueller, James P. Allison, Wolfgang Wrasidlo, Holger N. Lode, Yunping Luo, Stephen D. Gillies, AhKau Ng, Ursula Wargalla-Plate
Publikováno v:
Cancer Research. 81:1429-1430
[][1] The sad news that Ralph A. Reisfeld, PhD, passed away on December 6, 2020 reached us early this year, and we would like to reflect on Ralph's long career and distinctive contribution to biomedical science and in particular to the field of cance
Autor:
Joal D. Beane, David Paschon, Richard A. Morgan, Mary A. Black, Martin A. Giedlin, Andreas Reik, Philip D. Gregory, Zhili Zheng, Jeffrey C. Miller, Gary Lee, Daniel Abate-Daga, Michael C. Holmes, Matthew C. Mendel, Edward J. Rebar, Dmitry Guschin, Zhiya Yu, Smita S. Chandran, Mini Bharathan, Steven A. Feldman, Nicholas P. Restifo, Nimisha Gandhi, Dale Ando, Steven A. Rosenberg
Publikováno v:
Molecular Therapy. 23:1380-1390
Programmed cell death-1 (PD-1) is expressed on activated T cells and represents an attractive target for gene-editing of tumor targeted T cells prior to adoptive cell transfer (ACT). We used zinc finger nucleases (ZFNs) directed against the gene enco
Autor:
Nicholas Chomont, Gary Lee, Jacob Lalezari, Winson Tang, Geoff Nichol, Shelley Wang, Rafick-Pierre Sekaly, Remy Fromentin, Joumana Zeidan, Martin A. Giedlin, Dale Ando, Ronald T. Mitsuyasu
Publikováno v:
Molecular Therapy. 23
Background: Nine aviremic HIV+ subjects on ART with CD4 counts between 200-500 cells/mm3 received 10-30 billion SB-728-T cells. Sustained CD4 increases in peripheral blood (PB) were observed in all treated subjects (median +103 cells/mm3 at 1 year).
Autor:
Y Gao, Anat A. Herskovits, Joanne Y.H. Lim, Adam Sampson-Johannes, David N. Cook, Martin A. Giedlin, John E. Hearst, Keith S. Bahjat, W Liu, William S. Luckett, D Kapadia, A Stassinopoulos, Pamela Schnupf, Thomas W. Dubensky, G Castro, H. G. Archie Bouwer, Dirk G. Brockstedt, M Leong, Daniel A. Portnoy
Publikováno v:
Nature Medicine. 11:853-860
We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision r
Autor:
Weiqun Liu, William S. Luckett, Yi Gao, Dirk G. Brockstedt, Daniel A. Portnoy, Thomas W. Dubensky, Keith S. Bahjat, Martin A. Giedlin, David N. Cook, Meredith L. Leong
Publikováno v:
Proceedings of the National Academy of Sciences. 101:13832-13837
The facultative intracellular bacteriumListeria monocytogenesis being developed as a cancer vaccine platform because of its ability to induce potent innate and adaptive immunity. For successful clinical application, it is essential to develop aLister
Autor:
Jeff F. Miller, Holly J. Starks, Ronald A. Barry, David J. Hinrichs, Darren E. Higgins, H. G. Archie Bouwer, Thomas W. Dubensky, Dirk G. Brockstedt, Martin A. Giedlin, Kevin W. Bruhn, Hao Shen
Publikováno v:
The Journal of Immunology. 173:420-427
The bacterium L. monocytogenes is a proposed vaccine carrier based upon the observation that this pathogen replicates within the intracytoplasmic environment facilitating delivery of Ag to the endogenous Ag processing and presentation pathway with su
Autor:
Henry Masur, Richard T. Davey, Robert E. Walker, Julia A. Metcalf, Jeffrey M. Albert, Joseph A. Kovacs, Martin A. Giedlin, Gwendolyn Fyfe, Michael Baseler, Michael A. Polis, Judith Falloon, Stephen C. Piscitelli, Doreen G. Chaitt, H. Clifford Lane, Robin Dewar
Publikováno v:
The Journal of Infectious Diseases. 179:849-858
Forty-nine outpatients infected with human immunodeficiency virus with baseline CD4 cell counts >/=500/mm3, who were on stable antiretroviral therapy, were randomized to receive 5-day cycles of either low-dose (1.5 million IU [MIU] twice a day) or hi
Autor:
Smita S. Chandran, Joal D. Beane, Dale Ando, Gary Lee, Richard A. Morgan, Steven A. Rosenberg, Andreas Reik, Zhili Zheng, Steven A. Feldman, Zhiya Yu, Sadik H. Kassim, Nicholas P. Restifo, Ed Rebar, Mary A. Black, Michael C. Holmes, Martin A. Giedlin, Matthew C. Mendel, Mini Bharathan, Nimisha Gandhi, Philip D. Gregory, Daniel Abate-Daga
Publikováno v:
Molecular Therapy. 23:S33-S34
Multiple inhibitory pathways are exploited by a number of cancers to block the body's immune response which may limit the effectiveness of adoptive cell transfer (ACT). Programmed cell death-1 (PD-1) is a member of the CD28 superfamily and is express