Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Martin Norin"'
Autor:
Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhib
Externí odkaz:
https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c524
Autor:
Mohammad, Hojjat-Farsangi, Ali, Moshfegh, Johan, Schultz, Martin, Norin, Thomas, Olin, Anders, Österborg, Håkan, Mellstedt
Publikováno v:
Handbook of experimental pharmacology. 269
Receptor tyrosine kinases (RTKs) are frequently dysregulated in malignancies and important for the malignant characteristics of tumor cells. RTKs are attractive structures for drug targeting of cancer. The RTK ROR1 is of significance during embryogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41213b9484f21d6c978b466a72981061
https://pubmed.ncbi.nlm.nih.gov/34490515
https://pubmed.ncbi.nlm.nih.gov/34490515
Autor:
Ali Moshfegh, Mohammad Hojjat-Farsangi, Johan Schultz, Anders Österborg, Thomas Olin, Håkan Mellstedt, Martin Norin
Publikováno v:
Pharmacology of the WNT Signaling System ISBN: 9783030854980
Receptor tyrosine kinases (RTKs) are frequently dysregulated in malignancies and important for the malignant characteristics of tumor cells. RTKs are attractive structures for drug targeting of cancer. The RTK ROR1 is of significance during embryogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055bf52e4f5cd58ae393e40b864ca1ed
https://doi.org/10.1007/164_2021_535
https://doi.org/10.1007/164_2021_535
Autor:
Jessica Hollers, Martin Norin, Katarina Färnegårdh, Jemina Lehto, Nadilly Bonagas, N. Markova, Carina Norström, Anna Huguet Ninou, Petra Groth, Nina M. S. Gustafsson, Martin Andersson, Jessica Martinsson, Baek Kim, Elisee Wiita, Rosa Pennisi, Thomas Olin, Kenth Hallberg, Johan Schultz, Mattias Jönsson, Petra Marttila, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ea467c334b76d93f503c7eee3f7fb8
Autor:
Elias Drakos, Mohammad Hojjat-Farsangi, Håkan Mellstedt, Martin Norin, Amineh Ghaderi, George Z. Rassidakis, Fariba Mozaffari, Ali Moshfegh, Johan Schultz, Thomas Olin, Johanna Aschan, Birgitta Sander, Anders Österborg
Publikováno v:
Blood. 134:5312-5312
Background: ROR1 - a receptor tyrosine kinase (RTK) - is essential for normal embryonic development, but is absent on most normal adult tissues. ROR1 is of importance of cell proliferation, differentiation, survival and metabolism. However, ROR1 is o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5d91fa69ac9843f864e3d87510e245
https://doi.org/10.1182/blood-2019-129773
https://doi.org/10.1182/blood-2019-129773
Autor:
Parviz Kokhaei, Håkan Mellstedt, Jan Vågberg, Thomas Olin, Martin Norin, Elias Drakos, Charlotta Löfberg, George Z. Rassidakis, Charlotta Carina Norström, AmirHossein Daneshmanesh, Anders Österborg, Elisabeth Olsson, Jemina Lehto, Mohammad Hojjat-Farsangi, Johan Schultz, Ali Moshfegh, Amineh Ghaderi
Publikováno v:
Blood. 134:2565-2565
Background: Receptor tyrosine kinase (RTK) (ROR1) is normally expressed during embryogenesis but absent in most normal tissues. However, ROR1 is overexpressed in several cancers (onco-fetal RTK) and of importance for various tumor cell functions such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0208c4a9402e8f9a6a1108592959c6a3
https://doi.org/10.1182/blood-2019-126801
https://doi.org/10.1182/blood-2019-126801
Autor:
T Easter, M. D. Lewis, Juan Pedro López-Siguero, David Neil Cooper, David Stuart Millar, Nieves Díaz-Torrado, Annie M. Procter, Linda Fryklund, John Gregory, Luis Fernando López-Canti, Rafael Espino, Cristóbal-Jorge Del Valle, Vicky Newsway, Maurice F. Scanlon, Martin Horan, Ramón Cañete, Martin Norin, Angels Ulied
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:1068-1075
The pituitary-expressed GH1 gene was screened for mutation in a group of 74 children with familial short stature. Two novel mutations were identified: an Ile179Met substitution and a −360A→G promoter variant. The Ile179Met variant was shown to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508bfa8233face2a1a5189fdf12a8091
https://doi.org/10.1210/jc.2003-030652
https://doi.org/10.1210/jc.2003-030652
Autor:
Michael Krawczak, Martin Horan, T Easter, Elizabeth Crowne, John Gregory, John A. Phillips, Phillip Edwards, Linda Fryklund, David Neil Cooper, Victoria Elizabeth Newsway, Annie M. Procter, Sally J. Davies, M. D. Lewis, Martin Norin, Kim Waldron, Jeremy Kirk, Patricia J. Smith, David Stuart Millar, Maurice F. Scanlon
Publikováno v:
Human Mutation. 21:424-440
Subtle mutations in the growth hormone 1 (GH1) gene have been regarded as a comparatively rare cause of short stature. Such lesions were sought in a group of 41 individuals selected for short stature, reduced height velocity, and bone age delay; a gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d677d1369fd8e9b74b79c79579b7548
https://doi.org/10.1002/humu.10168
https://doi.org/10.1002/humu.10168
Autor:
Martin Norin, Michael Sundstrom
Publikováno v:
Il Farmaco. 57:947-951
The genomics efforts have identified a large number of novel genes and thus provided a pool of interesting but not functionally characterized target proteins. It has been suggested that structural proteomics will significantly impact the success rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1322bb32b3f30ca843505a5aea42cf
https://doi.org/10.1016/s0014-827x(02)01212-0
https://doi.org/10.1016/s0014-827x(02)01212-0
Autor:
Michael Sundstrom, Martin Norin
Publikováno v:
Trends in Biotechnology. 20:79-84
The major challenge for post-genomic research is to functionally assign and validate a large number of novel target genes and their corresponding proteins. Functional genomics approaches have, therefore, gained considerable attention in the quest to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcbcbaf11ecd355bc0168e6be5ddb17
https://doi.org/10.1016/s0167-7799(01)01884-4
https://doi.org/10.1016/s0167-7799(01)01884-4