Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Martin Michels"'
Autor:
Karl Ziegelbauer, Dominik Mumberg, Michael Brands, Franz von Nussbaum, Bertolt Kreft, Martin Michels, Oliver von Ahsen, Anna-Lena Frisk, Marian Raschke, Stefan Prechtl, Benjamin Bader, Philip Lienau, Roland Neuhaus, Detlef Stoeckigt, Ulrich Klar, Dirk Kosemund, Volker Schulze, Marcus Koppitz, Gerhard Siemeister, Antje M. Wengner
Effect of BAY 1217389 in monotherapy and combination therapy with paclitaxel on total KNL1 in A2780Cis tumors in nude mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0b68fc1d8f214b0b3e08ca88297410
https://doi.org/10.1158/1535-7163.22508437.v1
https://doi.org/10.1158/1535-7163.22508437.v1
Autor:
Karl Ziegelbauer, Dominik Mumberg, Michael Brands, Franz von Nussbaum, Bertolt Kreft, Martin Michels, Oliver von Ahsen, Anna-Lena Frisk, Marian Raschke, Stefan Prechtl, Benjamin Bader, Philip Lienau, Roland Neuhaus, Detlef Stoeckigt, Ulrich Klar, Dirk Kosemund, Volker Schulze, Marcus Koppitz, Gerhard Siemeister, Antje M. Wengner
Multinuclearity in U2OS cells induced by Mps1 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921d9472516e80123b05471c837506f
https://doi.org/10.1158/1535-7163.22508449.v1
https://doi.org/10.1158/1535-7163.22508449.v1
Autor:
Karl Ziegelbauer, Dominik Mumberg, Michael Brands, Franz von Nussbaum, Bertolt Kreft, Martin Michels, Oliver von Ahsen, Anna-Lena Frisk, Marian Raschke, Stefan Prechtl, Benjamin Bader, Philip Lienau, Roland Neuhaus, Detlef Stoeckigt, Ulrich Klar, Dirk Kosemund, Volker Schulze, Marcus Koppitz, Gerhard Siemeister, Antje M. Wengner
H&E stained A2780cis tumors after treatment with vehicle paclitaxel alone BAY 1161909 alone or in combination with BAY 1161909 and paclitaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9c126cf3b030f5383bcf8d4111e2f2
https://doi.org/10.1158/1535-7163.22508446.v1
https://doi.org/10.1158/1535-7163.22508446.v1
Autor:
Karl Ziegelbauer, Dominik Mumberg, Michael Brands, Franz von Nussbaum, Bertolt Kreft, Martin Michels, Oliver von Ahsen, Anna-Lena Frisk, Marian Raschke, Stefan Prechtl, Benjamin Bader, Philip Lienau, Roland Neuhaus, Detlef Stoeckigt, Ulrich Klar, Dirk Kosemund, Volker Schulze, Marcus Koppitz, Gerhard Siemeister, Antje M. Wengner
Additional data showing pharmacological characterization of Mps1 Inhibitors BAY 1161909 and BAY 1217389; Suppl. Table 1: Kinase selectivity profile of BAY 1161909; Suppl. Table 2: Kinase selectivity profile of BAY 1217389; Suppl. Table 3: Kinase sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471af036b499cdbb44ed74a80af4d2c5
https://doi.org/10.1158/1535-7163.22508434.v1
https://doi.org/10.1158/1535-7163.22508434.v1
Autor:
Karl Ziegelbauer, Dominik Mumberg, Michael Brands, Franz von Nussbaum, Bertolt Kreft, Martin Michels, Oliver von Ahsen, Anna-Lena Frisk, Marian Raschke, Stefan Prechtl, Benjamin Bader, Philip Lienau, Roland Neuhaus, Detlef Stoeckigt, Ulrich Klar, Dirk Kosemund, Volker Schulze, Marcus Koppitz, Gerhard Siemeister, Antje M. Wengner
Effect of BAY 1161909 in monotherapy on the frequencies of peripheral blood reticulocytes and micronuclei-harboring reticulocytes in nude mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab6e5c8aa529b99980fb121751c20dc
https://doi.org/10.1158/1535-7163.22508443.v1
https://doi.org/10.1158/1535-7163.22508443.v1
Autor:
Claudia Merz, Marcus Bauser, Martin Michels, Ashley Eheim, David T. Scadden, Henrik Seidel, Ralf Lesche, Timo Stellfeld, Hanna Meyer, Pascale Lejeune, Thomas Mueller, Detlef Stoeckigt, David B. Sykes, Steven James Ferrara, Sven Christian, Andrea Haegebarth, Judith Guenther, Andreas Janzer, Katja Zimmermann, Sherif El Sheikh, Stefan Gradl, Michael Bruening
Publikováno v:
Cancer Research. 78:DDT02-04
Acute myeloid leukemia (AML), the most common acute leukemia in adults, is an aggressive hematologic malignancy resulting in bone marrow failure with a poor outcome; overall survival is approximately 25% at five years. Treatment options, in particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810e228e308047a51f2ef7b9122f3063
https://doi.org/10.1158/1538-7445.am2018-ddt02-04
https://doi.org/10.1158/1538-7445.am2018-ddt02-04
Autor:
Ningshu Liu, Franziska Siegel, Lars Bärfacker, Franz von Nussbaum, Karl Ziegelbauer, Ulf Bömer, William J. Scott, Stuart Ince, Amaury Ernesto Fernandez-Montalvan, Dominik Mumberg, Kirstin Meyer, Roland Neuhaus, Martin Michels, Oliver Politz, Andrea Hägebarth
Publikováno v:
International Journal of Cancer. 140:449-459
The PI3K-AKT-mTOR signaling cascade is activated in the majority of human cancers, and its activation also plays a key role in resistance to chemo and targeted therapeutics. In particular, in both breast and prostate cancer, increased AKT pathway act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ce2c1e9fe2894b3e55ba673689a4f45
https://doi.org/10.1002/ijc.30457
https://doi.org/10.1002/ijc.30457
Autor:
Katja Zimmermann, Henrik Seidel, Vera Puetter, Sherif El Sheikh, Steven James Ferrara, Stefan Gradl, Claudia Merz, Anders Friberg, Sven Christian, Andrea Haegebarth, Thomas Mueller, Ashley Eheim, Timo Stellfeld, David T. Scadden, Marcus Bauser, Duy Nguyen, Michael Niehues, Martina Schaefer, Michael Bruening, Martin Michels, Judith Guenther, Knut Eis, Detlef Stoeckigt, Hanna Meyer, Pascal Lejeune, Andreas Janzer, Han-Jie Zhou, David B. Sykes, Michael Kroeber
Publikováno v:
Cancer Research. 79:2-2
DHODH is a key enzyme in the biosynthesis of pyrimidines and recent studies have renewed interest in this old anti-cancer target. Here, we disclose the discovery of 4-triazolosalicylamides as inhibitors of DHODH and their structure activity relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6ee917949e8111944b8c7f5491d2229
https://doi.org/10.1158/1538-7445.am2019-2
https://doi.org/10.1158/1538-7445.am2019-2
Autor:
Ingo Flamme, Iring Heisler, Michael Haerter, Peter Ellinghaus, Alexander Ehrmann, Susanne Greschat, Felix Oehme, Hartmut Beck, Martin Michels, Holger Summer, Karl Ziegelbauer, Holger Hess-Stumpp, Karl-Heinz Thierauch, Kerstin Unterschemmann
Publikováno v:
Cancer Medicine
The activation of the transcription factor hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development, tumor progression, and resistance to chemo- and radiotherapy. In order to identify compounds targeting the HIF pathway, a smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174a861d462f2de1915952cca5fb3aa
https://doi.org/10.1002/cam4.112
https://doi.org/10.1002/cam4.112
Autor:
Oliver, Politz, Franziska, Siegel, Lars, Bärfacker, Ulf, Bömer, Andrea, Hägebarth, William J, Scott, Martin, Michels, Stuart, Ince, Roland, Neuhaus, Kirstin, Meyer, Amaury Ernesto, Fernández-Montalván, Ningshu, Liu, Franz, von Nussbaum, Dominik, Mumberg, Karl, Ziegelbauer
Publikováno v:
International journal of cancer. 140(2)
The PI3K-AKT-mTOR signaling cascade is activated in the majority of human cancers, and its activation also plays a key role in resistance to chemo and targeted therapeutics. In particular, in both breast and prostate cancer, increased AKT pathway act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4779ff9245f0f8c406ddc4715ef7e9cf
https://pubmed.ncbi.nlm.nih.gov/27699769
https://pubmed.ncbi.nlm.nih.gov/27699769