Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Martin C. Dyroff"'
Autor:
Edward P. Vacek, Thomas Michael Bare, Martin C. Dyroff, Kathy L. Neilson, Rebecca Urbanek, J. Empfield, Alan S. Kirschner, Christine Barlaam, Joseph Lewis, Chi-Ming C. Lee, Wenhua Xiao, Megan Murphy, Vernon Alford, Janet Marie Forst, Gary Steelman, Shephali Trivedi, Richard A. Keith, Frances M. Mclaren, Dean G. Brown, Keith John Herzog, Horchler Carey
Publikováno v:
Journal of Medicinal Chemistry. 50:3113-3131
A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the glycine site of the NMDA receptor. In some cases, these compounds possessed poor aqueous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e6df439ce03cdca255c44c5222f7a4
https://doi.org/10.1021/jm060212s
https://doi.org/10.1021/jm060212s
Autor:
Dean G. Brown, Kathy L. Neilson, Horchler Carey, Thomas Michael Bare, Frances M. Mclaren, Gary Steelman, James Empfield, Richard A. Keith, Martin C. Dyroff, Wenhua Xiao, Rebecca Urbanek, Janet Marie Forst, Chi-Ming C. Lee, Shephali Trivedi, Keith John Herzog, Megan Murphy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3553-3556
Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5c094ed082aa4e657e79b5ec88d0a5
https://doi.org/10.1016/s0960-894x(03)00750-9
https://doi.org/10.1016/s0960-894x(03)00750-9
Autor:
Thomas M. Bare, Dean G. Brown, Carey L. Horchler, Megan Murphy, Rebecca A. Urbanek, Vernon Alford, Christine Barlaam, Martin C. Dyroff, James B. Empfield, Janet M. Forst, Keith J. Herzog, Richard A. Keith, Alan S. Kirschner, Chi-Ming C. Lee, Joseph Lewis, Frances M. McLaren, Kathy L. Neilson, Gary B. Steelman, Shephali Trivedi, Edward P. Vacek
Publikováno v:
Journal of Medicinal Chemistry; Jun2007, Vol. 50 Issue 13, p3113-3131, 19p
Publikováno v:
Carcinogenesis. 7:247-251
Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCCA), with a 100% incidence in the left and right median lobes and a 30% incidence in the right anterior lobe 20 weeks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebfb6eb35843b9477d661666929428a
https://doi.org/10.1093/carcin/7.2.247
https://doi.org/10.1093/carcin/7.2.247
Autor:
Uwe Kirstein, Martin C. Dyroff, Nam Ho Huh, James A. Popp, Mary A. Bedell, James A. Swenberg, Manfred F. Rajewsky
Publikováno v:
Proceedings of the National Academy of Sciences. 81:1692-1695
In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates in the DNA of nonparenchymal cells (NPC) but is efficiently removed from hepatocellular DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b958bf9134ec1327469ec8d341431d3
https://doi.org/10.1073/pnas.81.6.1692
https://doi.org/10.1073/pnas.81.6.1692
Publikováno v:
Environmental Health Perspectives
An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis to establish the correlation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95723514119fd185e16bf2194cdc5d5b
https://doi.org/10.1289/ehp.8562177
https://doi.org/10.1289/ehp.8562177
Publikováno v:
Carcinogenesis. 6:625-629
Recent experiments have demonstrated that O6-alkylguanine is rapidly removed from hepatocyte DNA following continuous exposure to 1,2-dimethylhydrazine or diethylnitrosamine. In contrast, O4-ethyldeoxythymidine accumulates to concentrations more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01a256a335e727c61bcffcfe408313f
https://doi.org/10.1093/carcin/6.4.625
https://doi.org/10.1093/carcin/6.4.625
Publikováno v:
Chemico-biological interactions. 45(3)
Lorsque des souches de souris ayant une forte (C3H) et une faible (C57BL) incidence de carcinome hepatocellulaire spontane sont comparees aucune difference dans l'activite de l'O 6 AGAAP n'a pu etre mise en evidence dans les hepatocytes des souris de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb156f02f83f6f70a8415d61fb0ed4f7
https://pubmed.ncbi.nlm.nih.gov/6883578
https://pubmed.ncbi.nlm.nih.gov/6883578
Publikováno v:
Chemico-biological interactions. 52(2)
The mononitrotoluenes are important industrial chemicals which display isomeric specificity in their ability to induce hepatic DNA excision repair in Fischer-344 rats. Covalent binding of the structurally related hepatocarcinogen, 2,6-dinitrotoluene,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0b51f0beb4cee75f9c842cd711be17
https://pubmed.ncbi.nlm.nih.gov/6595071
https://pubmed.ncbi.nlm.nih.gov/6595071
Publikováno v:
Carcinogenesis. 5(9)
The sulfotransferase inhibitors 2,6-dichloro-4-nitrophenol and pentachlorophenol were used to investigate the role of sulfate ester formation during the in vivo bioactivation of 2,4- and 2,6-dinitrotoluene (DNT). Male F-344 rats were administered one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f29678c7e7ccdb5318d7f74744b9f6
https://pubmed.ncbi.nlm.nih.gov/6590136
https://pubmed.ncbi.nlm.nih.gov/6590136