Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Martin Črnugelj"'
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 639 (2020)
Venetoclax is an orally bioavailable, B-cell lymphoma-2 (BCL-2) selective inhibitor, used for the treatment of various types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In this study we investiga
Externí odkaz:
https://doaj.org/article/6d416e0b76d343bd87be443c869a3f74
Publikováno v:
Applied Microbiology and Biotechnology. 106:1521-1530
Abstract Streptomyces clavuligerus is an industrially important producer of clavulanic acid (CA), a β-lactamase inhibitor which is used together with amoxicillin in one of the most widely prescribed antibacterial medicines, the co-amoxiclav. In a mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09fde54804fdecf50045ebec97d8847c
https://doi.org/10.1007/s00253-022-11805-5
https://doi.org/10.1007/s00253-022-11805-5
Publikováno v:
Applied microbiology and biotechnology. 106(4)
Streptomyces clavuligerus is an industrially important producer of clavulanic acid (CA), a β-lactamase inhibitor which is used together with amoxicillin in one of the most widely prescribed antibacterial medicines, the co-amoxiclav. In a mid-eightie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98d432a198b8c4422dab3f6166fb7ce9
https://pubmed.ncbi.nlm.nih.gov/35138454
https://pubmed.ncbi.nlm.nih.gov/35138454
Publikováno v:
Synthesis. 46:2333-2346
An expedient and simple synthetic approach to pitavastatin and rosuvastatin final intermediates is described. The presented approach consists of completely stereoselective Julia–Kocienski olefination step (E/Z up to 300:1) between lactonized stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc733986048112939c1e55f15fe11338
https://doi.org/10.1055/s-0033-1338648
https://doi.org/10.1055/s-0033-1338648
Publikováno v:
Tetrahedron Letters. 56:529-531
Orthogonally protected aminocyclopentitols were synthesized from commercially available aldopentoses using a convenient three-step procedure that does not require protection of the free anomeric hydroxyl group of the starting carbohydrate. The synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374bf1b9f77e282ca8aaec3343f56659
https://doi.org/10.1016/j.tetlet.2014.12.008
https://doi.org/10.1016/j.tetlet.2014.12.008
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5735-5744
We have recently communicated that DNA oligonucleotide d(G(3)T(4)G(4)) forms a dimeric G-quadruplex in the presence of K(+) ions [J. Am. Chem. Soc.2003, 125, 7866-7871]. The high-resolution NMR structure of d(G(3)T(4)G(4))(2) G-quadruplex exhibits G-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90ddd6fea2f58171b1f33c8f2a1bdf3
https://doi.org/10.1016/j.bmc.2004.08.009
https://doi.org/10.1016/j.bmc.2004.08.009
Publikováno v:
Journal of Molecular Biology. 320:911-924
The G-rich 11-mer oligonucleotide d(G(4)T(4)G(3)) forms a bimolecular G-quadruplex in the presence of sodium ions with a topology that is distinct from the folds of the closely related and well-characterized sequences d(G(4)T(4)G(4)) and d(G(3)T(4)G(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7b3be747e0079e426d07443940a85c
https://doi.org/10.1016/s0022-2836(02)00569-7
https://doi.org/10.1016/s0022-2836(02)00569-7
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1433-1438
A variable temperature-dependent 1H NMR conformational analysis of 3JHH coupling constants and NOE enhancements of a series of 8-aza-3-deaza modified guanine nucleosides 2 and 4–8 has been performed in DMSO-d6 and the results compared to those for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::185f699106de5381428a59a36972b06f
https://doi.org/10.1039/b009401n
https://doi.org/10.1039/b009401n
Publikováno v:
Organicbiomolecular chemistry. 2(14)
2D NMR studies demonstrate that the residence lifetime of 15NH4+ ions within the bimolecular G-quadruplex adopted by d(G4T4G4) is reduced from 270 ms in the presence of ammonium ions alone to 36 ms in the presence of Na+ ions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aa32e487ac9d59cbf1145d50eb7bf4
https://pubmed.ncbi.nlm.nih.gov/15254621
https://pubmed.ncbi.nlm.nih.gov/15254621
Publikováno v:
Journal of the American Chemical Society. 125(26)
NMR study has shown that DNA oligonucleotide d(G(3)T(4)G(4)) adopts an asymmetric bimolecular G-quadruplex structure in solution. The structure of d(G(3)T(4)G(4))(2) is composed of three G-quartets, overhanging G11 residue and G3, which is part of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a937efd546265f1bbaf927f57b702f6f
https://pubmed.ncbi.nlm.nih.gov/12823005
https://pubmed.ncbi.nlm.nih.gov/12823005