Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Martin, van der Valk"'
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf
PDF - 278KB, Supplemental figure 1. pH equilibrium between the lactone (closed ring) form and free carboxylic acid (open) form of irinotecan and SN-38. Supplemental Figure 2. Role of Oatp1a/1b uptake transporters in small intestinal (tissue plus cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638cae802c59446336feae0b2f280b61
https://doi.org/10.1158/1535-7163.22500156.v1
https://doi.org/10.1158/1535-7163.22500156.v1
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf
Organic anion-transporting polypeptides (OATP) mediate the hepatic uptake of many drugs, thus codetermining their clearance. Impaired hepatic clearance due to low-activity polymorphisms in human OATP1B1 may increase systemic exposure to SN-38, the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7919a874f439756c790a463f50f88691
https://doi.org/10.1158/1535-7163.c.6536373.v1
https://doi.org/10.1158/1535-7163.c.6536373.v1
Autor:
Bart A Westerman, Marleen Blom, Ellen Tanger, Martin van der Valk, Ji-Ying Song, Marije van Santen, Jules Gadiot, Paulien Cornelissen-Steijger, John Zevenhoven, Haydn M Prosser, Anthony Uren, Eleonora Aronica, Maarten van Lohuizen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35943 (2012)
Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types of cancer, including tumors of astroglial and neural
Externí odkaz:
https://doaj.org/article/6af8facbcc884638a76bf0cd182d6c29
Autor:
Claudia Gaspar, Patrick Franken, Lia Molenaar, Cor Breukel, Martin van der Valk, Ron Smits, Riccardo Fodde
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000547 (2009)
Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of ex
Externí odkaz:
https://doaj.org/article/124db0947e784f8db7107eceb9a390b5
Publikováno v:
Familial Cancer. 16:221-229
Missense variants of DNA mismatch repair (MMR) genes pose a problem in clinical genetics as long as they cannot unambiguously be assigned as the cause of Lynch syndrome (LS). To study such variants of uncertain clinical significance, we have develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4f9d2fc780194b661ba8046017f275
https://doi.org/10.1007/s10689-016-9945-x
https://doi.org/10.1007/s10689-016-9945-x
Autor:
Martin van der Valk, Maarten Loos, Jaap J. Plomp, Bastijn Koopmans, Alexander J. Groffen, Matthijs Verhage, Elizabeth M. van der Pijl, Cornelia J. Geerts
Publikováno v:
Brain Structure and Function, 220(4), 1971-1982
Brain Structure and Function, 220(4), 1971-1982. Springer Verlag
Geerts, C J, Plomp, J J, Koopmans, B, Loos, M, van der Pijl, EM, van der Valk, M A, Verhage, M & Groffen, A J A 2015, ' Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates. ', Brain Structure and Function, vol. 220, no. 4, pp. 1971-1982 . https://doi.org/10.1007/s00429-014-0766-0
Brain Structure and Function, 220(4), 1971-1982. Springer Verlag
Geerts, C J, Plomp, J J, Koopmans, B, Loos, M, van der Pijl, EM, van der Valk, M A, Verhage, M & Groffen, A J A 2015, ' Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates. ', Brain Structure and Function, vol. 220, no. 4, pp. 1971-1982 . https://doi.org/10.1007/s00429-014-0766-0
Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in the mammalian nervous system is still unclear. Here we generated tomosyn-2 null (Tom2(KO/KO))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7930a2ae4a97053930900363b9e48c
https://doi.org/10.1007/s00429-014-0766-0
https://doi.org/10.1007/s00429-014-0766-0
Autor:
Martin van der Valk, Jaap Willem Hol, Durk Fekkes, Felix van Lier, Robert Jan Stolker, Markus Klimek
Publikováno v:
Annals of Surgery, 258(6), 1072-1078. Lippincott Williams & Wilkins
OBJECTIVE:: To determine the effect of surgical invasiveness on plasma levels of arginine, citrulline, ornithine, and nitric oxide (NO) in humans. BACKGROUND:: Surgical trauma may have a profound effect on the metabolism of NO. However, human studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf2d1a531fcb30ec01305fecf0192b4
https://doi.org/10.1097/sla.0b013e3182856ade
https://doi.org/10.1097/sla.0b013e3182856ade
Autor:
Martin van der Valk, Werner Helvensteijn, Sigrid M. A. Swagemakers, Patrick Franken, Asha M. Das, Elvira R M Bakker, Ernst J. Kuipers, Ron Smits, Wendy van Veelen, Timo L.M. ten Hagen
Publikováno v:
Carcinogenesis, 34(11), 2629-2638. Oxford University Press
Whereas aberrant activation of canonical Wnt/β-catenin signaling underlies the majority of colorectal cancer cases, the contribution of non-canonical Wnt signaling is unclear. As enhanced expression of the most extensively studied non-canonical Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060f6c2cf0d9516bdea1b41f74f923f3
https://pure.eur.nl/en/publications/d1196931-bc14-4078-b0fd-030c7ac164b3
https://pure.eur.nl/en/publications/d1196931-bc14-4078-b0fd-030c7ac164b3
Publikováno v:
The American Journal of Pathology. 181:785-794
The MAP kinase and PI3 kinase pathways have been identified as the most common pathways that mediate oncogenic transformation in melanoma, and the majority of compounds developed for melanoma treatment target one or the other of these pathways. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faae7440521fd3a241acbb1c596cbf26
https://doi.org/10.1016/j.ajpath.2012.06.002
https://doi.org/10.1016/j.ajpath.2012.06.002
Autor:
Johan P. de Winter, Sietske T. Bakker, Martin van der Valk, Marieke van de Ven, Sandra S. de Vries, Mariska A. D. Berns, Hein te Riele, Henri J. van de Vrugt, Jenny A. Visser, Piet Kramer, Elly Delzenne-Goette, Fré Arwert, Anja van der Wal, Anneke B. Oostra
Publikováno v:
Journal of Pathology, 226(1), 28-39. John Wiley and Sons Ltd
Bakker, S T, van der Vrugt, H J, Visser, J A, Delzenne-Goette, E, van der Wal, A, Berns, M A D, van de Ven, M, Oostra, A B, de Vries, S, Kramer, P, Arwert, F, van de Valk, M, de Winter, J P & te Riele, H P J 2012, ' Fancf-deficient mice are prone to develop ovarian tumours ', Journal of Pathology, vol. 226, no. 1, pp. 28-39 . https://doi.org/10.1002/path.2992
Journal of Pathology, 226(1), 28-39. John Wiley & Sons Ltd.
Bakker, S T, van der Vrugt, H J, Visser, J A, Delzenne-Goette, E, van der Wal, A, Berns, M A D, van de Ven, M, Oostra, A B, de Vries, S, Kramer, P, Arwert, F, van de Valk, M, de Winter, J P & te Riele, H P J 2012, ' Fancf-deficient mice are prone to develop ovarian tumours ', Journal of Pathology, vol. 226, no. 1, pp. 28-39 . https://doi.org/10.1002/path.2992
Journal of Pathology, 226(1), 28-39. John Wiley & Sons Ltd.
Fanconi anaemia (FA) is a rare recessive disorder marked by developmental abnormalities, bone marrow failure, and a high risk for the development of leukaemia and solid tumours. The inactivation of FA genes, in particular FANCF, has also been documen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453911b5432632f12ea1a6b85ec01bc8
https://doi.org/10.1002/path.2992
https://doi.org/10.1002/path.2992