Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Martin, Thurnher"'
Autor:
Renate Pichler, Gabriel Diem, Hubert Hackl, Jiří Koutník, Laura S. Mertens, David D`Andrea, Benjamin Pradere, Francesco Soria, Andrea Mari, Ekaterina Laukhtina, Wojciech Krajewski, Jeremy Yuen-Chun Teoh, Francesco Del Guidice, Marco Moschini, Martin Thurnher, Wilfried Posch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BCG is the most efficient adjuvant therapy for high-risk, non-muscle-invasive bladder cancer (NMIBC). Both innate and adaptive immune responses have been implicated in BCG-mediated effects. BCG vaccination can boost innate immune responses via traine
Externí odkaz:
https://doaj.org/article/3292851d0d8e44c394d83330342e1654
Autor:
Renate Pichler, Peter J. Siska, Piotr Tymoszuk, Agnieszka Martowicz, Gerold Untergasser, Roman Mayr, Florian Weber, Andreas Seeber, Florian Kocher, Dominik A. Barth, Martin Pichler, Martin Thurnher
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Renal cell carcinoma (RCC) is frequently infiltrated by immune cells, a process which is governed by chemokines. CD8+ T cells in the RCC tumor microenvironment (TME) may be exhausted which most likely influence therapy response and survival. The aim
Externí odkaz:
https://doaj.org/article/26dd55bbbaf4450489ea940ca2cd59b3
Autor:
Andrea Katharina Lindner, Gennadi Tulchiner, Andreas Seeber, Peter J. Siska, Martin Thurnher, Renate Pichler
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Fumarate hydratase (FH) - deficient renal cell carcinoma (FHdRCC) is a rare aggressive subtype of RCC caused by a germline or sporadic loss-of-function mutation in the FH gene. Here, we summarize how FH deficiency results in the accumulation of fumar
Externí odkaz:
https://doaj.org/article/34440c1f4d07413caebd68c900ac80ab
Autor:
Georg Gruenbacher, Hubert Gander, Andrea Rahm, Gabriele Dobler, Astrid Drasche, Jakob Troppmair, Walter Nussbaumer, Martin Thurnher
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the f
Externí odkaz:
https://doaj.org/article/f7527065a0d64848875bd47014568c8c
Autor:
Dominik Klaver, Martin Thurnher
Publikováno v:
Purinergic Signalling.
Although first cloning of the human ATP receptor P2Y11 was successful 25 years ago, the exact downstream signaling pathways of P2Y11 receptor, which can couple to Gq and Gs proteins, have remained unclear. Especially the lack of rodent models as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe9e5a2bba1a2e280310feebb274e86e
https://doi.org/10.1007/s11302-023-09932-3
https://doi.org/10.1007/s11302-023-09932-3
Autor:
Dominik Klaver, Martin Thurnher
Publikováno v:
Cells, Vol 10, Iss 5, p 1098 (2021)
Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To perform tissue stress surveillance, macrophages express many different stre
Externí odkaz:
https://doaj.org/article/8e5d626815cf44408bcf06108f54504a
Autor:
Georg Gruenbacher, Hubert Gander, Andrea Rahm, Marco Idzko, Oliver Nussbaumer, Martin Thurnher
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 444-456 (2016)
In humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood. Here, we show that
Externí odkaz:
https://doaj.org/article/339e160e75494bcf8f5bfbea32fff782
Autor:
Martin Thurnher, Andrea Rahm, Walter Nussbaumer, Oliver Nussbaumer, Hubert Gander, Georg Gruenbacher
Statins are inhibitors of cholesterol biosynthesis and protein prenylation that also have been studied in cancer therapy and chemoprevention. With regard to natural killer (NK) cells, only inhibitory effects of statins such as suppression of granule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73eb2114381b576b58827a5061c61a6
https://doi.org/10.1158/0008-5472.c.6501108.v1
https://doi.org/10.1158/0008-5472.c.6501108.v1
Autor:
Martin Thurnher, Andrea Rahm, Walter Nussbaumer, Oliver Nussbaumer, Hubert Gander, Georg Gruenbacher
Supplementary Methods, Figures 1-6 from IL-2 Costimulation Enables Statin-Mediated Activation of Human NK Cells, Preferentially through a Mechanism Involving CD56+ Dendritic Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330e59973425c930b311570721125408
https://doi.org/10.1158/0008-5472.22385109.v1
https://doi.org/10.1158/0008-5472.22385109.v1
Autor:
Oliver Nussbaumer, Martin Thurnher
Publikováno v:
Cells, Vol 9, Iss 3, p 772 (2020)
Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in hum
Externí odkaz:
https://doaj.org/article/f367999c0cad4443816e2491d7f0782d