Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Martin, Stahl"'
Publikováno v:
CHIMIA, Vol 77, Iss 7/8 (2023)
Successful structure-based drug design (SBDD) requires the optimization of interactions with the target protein and the minimization of ligand strain. Both factors are often modulated by small changes in the chemical structure which can lead to profo
Externí odkaz:
https://doaj.org/article/5a77acfa0fab4271b95d75928bcd2ac6
Autor:
Torsten P.M. Scheithauer, Hilde Herrema, Hongbing Yu, Guido J. Bakker, Maaike Winkelmeijer, Galina Soukhatcheva, Derek Dai, Caixia Ma, Stefan R. Havik, Manon Balvers, Mark Davids, Abraham S. Meijnikman, Ömrüm Aydin, Bert-Jan H. van den Born, Marc G. Besselink, Olivier R. Busch, Maurits de Brauw, Arnold van de Laar, Clara Belzer, Martin Stahl, Willem M. de Vos, Bruce A. Vallance, Max Nieuwdorp, C. Bruce Verchere, Daniël H. van Raalte
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied, but causal links remain enigmatic. Obese individuals with or without T2D were included from two independen
Externí odkaz:
https://doaj.org/article/51e301893b1e4bf7bc15c80a62ac3ab1
Autor:
Joannie M. Allaire, Anita Poon, Shauna M. Crowley, Xiao Han, Zohreh Sharafian, Navjit Moore, Martin Stahl, Brian Bressler, Pascal M. Lavoie, Kevan Jacobson, Xiaoxia Li, Bruce A. Vallance
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Intestinal epithelial cells (IEC) reside in close proximity to the gut microbiota and are hypo-responsive to bacterial products, likely to prevent maladaptive inflammatory responses. This is in part due to their strong expression of Single I
Externí odkaz:
https://doaj.org/article/15d2427d54394e72ab94d917fb2ea064
Autor:
Franziska A. Graef, Larissa S. Celiberto, Joannie M. Allaire, Mimi T. Y. Kuan, Else S. Bosman, Shauna M. Crowley, Hyungjun Yang, Justin H. Chan, Martin Stahl, Hongbing Yu, Candice Quin, Deanna L. Gibson, Elena F. Verdu, Kevan Jacobson, Bruce A. Vallance
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8 (2021)
Reducing food intake is a common host response to infection, yet it remains unclear whether fasting is detrimental or beneficial to an infected host. Despite the gastrointestinal tract being the primary site of nutrient uptake and a common route for
Externí odkaz:
https://doaj.org/article/8ccaa15743bd4f1987bf12c7c7818b6b
Autor:
Robert T. Patry, Martin Stahl, Maria Elisa Perez-Munoz, Harald Nothaft, Cory Q. Wenzel, Jessica C. Sacher, Colin Coros, Jens Walter, Bruce A. Vallance, Christine M. Szymanski
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Bacterial AB5 toxins, such as cholera toxin, bind to oligosaccharides on the host cell surface and play key roles in the pathogenesis of diarrheal disease. Here, Patry et al. show that these toxins bind also to bacterial oligosaccharides and inhibit
Externí odkaz:
https://doaj.org/article/c5e73df516cb42219cd70dc2bfef3ef5
Autor:
Shauna M Crowley, Xiao Han, Joannie M Allaire, Martin Stahl, Isabella Rauch, Leigh A Knodler, Bruce A Vallance
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008498 (2020)
We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase
Externí odkaz:
https://doaj.org/article/038531766fc4486bbc499e93c5ab38da
Autor:
Malcolm R. DeBaun, Brett P. Salazar, Yan Bai, Michael J. Gardner, Yunzhi Peter Yang, Chi-chun Pan, Alex Martin Stahl, Seydesina Moeinzadeh, Sungwoo Kim, Elaine Lui, Carolyn Kim, Sien Lin, L. Henry Goodnough, Harsh Wadhwa
Publikováno v:
Injury
OBJECTIVES: High energy long bone fractures with critical bone loss are at risk for nonunion without strategic intervention. We hypothesize that a synthetic membrane implanted at a single stage improves bone healing in a preclinical nonunion model. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0e123aa8d7001805bcd7a3c825ff79
https://doi.org/10.1016/j.injury.2022.01.015
https://doi.org/10.1016/j.injury.2022.01.015
Publikováno v:
ChemMedChem. 16:2760-2763
We retrace Prof. François Diederich's consultancy work for Roche and its impact over the years he worked with us. François Diederich uniquely shaped our approach to molecular design, and interactions with him and his research group at ETH Zurich ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61d9c3528f130bd3c60dd83af25ac58
https://doi.org/10.1002/cmdc.202100351
https://doi.org/10.1002/cmdc.202100351
Publikováno v:
Journal of chemical information and modeling. 62(7)
The Torsion Library is a collection of torsion motifs associated with angle distributions, derived from crystallographic databases. It is used in strain assessment, conformer generation, and geometry optimization. A hierarchical structure of expert c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e62be5e1304dbced8e102e3dcc8dbb2
https://pubmed.ncbi.nlm.nih.gov/35318851
https://pubmed.ncbi.nlm.nih.gov/35318851
Autor:
Martin Stahl, Manfred Wappler
Publikováno v:
Geriatrie-Report. 15:34-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a45921ab034a0a149cd1036405668efb
https://doi.org/10.1007/s42090-020-0199-2
https://doi.org/10.1007/s42090-020-0199-2