Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Martin, Smieško"'
Autor:
Moritz Winker, Antoine Chauveau, Martin Smieško, Olivier Potterat, Alexander Areesanan, Amy Zimmermann-Klemd, Carsten Gründemann
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Nonpsychotic mental diseases (NMDs) affect approximately 15% of pregnant women in the US. Herbal preparations are perceived a safe alternative to placenta-crossing antidepressants or benzodiazepines in the treatment of nonpsychotic mental di
Externí odkaz:
https://doaj.org/article/9ed505e676e844629dda6743efc4881a
Autor:
Christina Lamers, Xiaoguang Xue, Martin Smieško, Henri van Son, Bea Wagner, Nadja Berger, Georgia Sfyroera, Piet Gros, John D. Lambris, Daniel Ricklin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complemen
Externí odkaz:
https://doaj.org/article/0c7331cff4f34721b958795607a6055b
Autor:
Lydia Wehrli, Ioannis Galdadas, Lionel Voirol, Martin Smieško, Yves Cambet, Vincent Jaquet, Stéphane Guerrier, Francesco Luigi Gervasio, Serge Nef, Rita Rahban
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration ([Ca2+]i) and plays an essential role in sperm function. It is mainly activated by the steroid progesterone (P4) but is also promiscuously acti
Externí odkaz:
https://doaj.org/article/615465c0b9f74934804518fb5b8517a1
Autor:
Verena N. Schreier, Emre Çörek, Christian Appenzeller-Herzog, Beat J. Brüschweiler, Birgit Geueke, Martin F. Wilks, Benoit Schilter, Jane Muncke, Thomas J. Simat, Martin Smieško, Nicolas Roth, Alex Odermatt
Publikováno v:
Environment International, Vol 176, Iss , Pp 107978- (2023)
Background: The presence of polyethylene terephthalate (PET) oligomers in food contact materials (FCMs) is well-documented. Consumers are exposed through their migration into foods and beverages; however, there is no specific guidance for their safet
Externí odkaz:
https://doaj.org/article/73693be193ec4c62800623585ed38310
Autor:
Verena N. Schreier, Christian Appenzeller-Herzog, Beat J. Brüschweiler, Birgit Geueke, Martin F. Wilks, Thomas J. Simat, Benoit Schilter, Martin Smieško, Jane Muncke, Alex Odermatt, Nicolas Roth
Publikováno v:
Environment International, Vol 167, Iss , Pp 107387- (2022)
Background: Polyethylene terephthalate (PET) oligomers are ubiquitous in PET used in food contact applications. Consumer exposure by migration of PET oligomers into food and beverages is documented. However, no specific risk assessment framework or g
Externí odkaz:
https://doaj.org/article/cfc5cf1d66e842d398e0cc8842bf4e09
Autor:
Beatrice Wagner, Florian P. C. Binder, Xiaohua Jiang, Tobias Mühlethaler, Roland C. Preston, Said Rabbani, Martin Smieško, Oliver Schwardt, Beat Ernst
Publikováno v:
Molecules, Vol 28, Iss 6, p 2595 (2023)
The d-GlcNAc moiety in sialyl Lewisx (sLex, 1) acts predominantly as a linker to position the d-Gal and the l-Fuc moieties in the bioactive spatial orientation. The hypothesis has been made that the NHAc group of GlcNAc pushes the fucose underneath t
Externí odkaz:
https://doaj.org/article/09c92691cdac462f95168204e153b667
Autor:
Katarzyna Papaj, Patrycja Spychalska, Patryk Kapica, André Fischer, Jakub Nowak, Maria Bzówka, Manuel Sellner, Markus A. Lill, Martin Smieško, Artur Góra
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro. In addition to their known anticoagulants activity this potential inhibition could have an additional therapeutic eff
Externí odkaz:
https://doaj.org/article/a5bf9b16c24c4d5a81c32141595dbc98
Autor:
Charleen G. Don, Martin Smieško
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The annual increase in depression worldwide together with an upward trend in the use of alternative medicine as treatment asks for developing reliable safety profiles of herbal based medicine. A considerable risk on adverse reactions exists when herb
Externí odkaz:
https://doaj.org/article/1cf53596edde420584a4be1ad560fbc7
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2584-2595 (2017)
In general, carbohydrate–lectin interactions are characterized by high specificity but also low affinity. The main reason for the low affinities are desolvation costs, due to the numerous hydroxy groups present on the ligand, together with the typi
Externí odkaz:
https://doaj.org/article/604f6c401e1b4d23b39c56c9495314c7
Autor:
Katarzyna Papaj, Patrycja Spychalska, Katarzyna Hopko, Patryk Kapica, Andre Fisher, Markus A. Lill, Weronika Bagrowska, Jakub Nowak, Katarzyna Szleper, Martin Smieško, Anna Kasprzycka, Artur Góra
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1153 (2021)
In the present study we tested, using the microscale thermophoresis technique, a small library of thionocarbamates, thiolocarbamates, sulfide and disulfide as potential lead compounds for SARS-CoV-2 Mpro drug design. The successfully identified binde
Externí odkaz:
https://doaj.org/article/cfc8ba5fbeaa4b28b89a3a1f556103ea