Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Martin, Sjöström"'
Autor:
Anouk C. de Jong, Alexandra Danyi, Job van Riet, Ronald de Wit, Martin Sjöström, Felix Feng, Jeroen de Ridder, Martijn P. Lolkema
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Prostate cancer is known to have a variable response to androgen receptor signalling inhibitors. Here, the authors use machine learning to predict response to therapy from genomic, transcriptomic and clinical data.
Externí odkaz:
https://doaj.org/article/e58d41290711477f987b222a1895084f
Autor:
Tommaso De Marchi, Paul Theodor Pyl, Martin Sjöström, Susanne Erika Reinsbach, Sebastian DiLorenzo, Björn Nystedt, Lena Tran, Gyula Pekar, Fredrik Wärnberg, Irma Fredriksson, Per Malmström, Mårten Fernö, Lars Malmström, Johan Malmstöm, Emma Niméus
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
A proteogenomic analysis of matching primary breast cancer and ipsilateral breast tumor recurrence (IBTR) samples provides insight into the development of IBTR and may be useful in identifying biomarkers for IBTR formation.
Externí odkaz:
https://doaj.org/article/7fcdfaaf09f349e4a6ae38eff9a3e17b
Autor:
Hamza Bakhtiar, Kyle T. Helzer, Yeonhee Park, Yi Chen, Nicholas R. Rydzewski, Matthew L. Bootsma, Yue Shi, Paul M. Harari, Marina Sharifi, Martin Sjöström, Joshua M. Lang, Menggang Yu, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can “phenocopy” pathogenic mutations, but would not be identified using standard clinical sequencing
Externí odkaz:
https://doaj.org/article/e2291cadffc94043a32301fcbd5da0f7
Autor:
Ying Z. Mazzu, YuRou Liao, Subhiksha Nandakumar, Martin Sjöström, Lina E. Jehane, Romina Ghale, Barani Govindarajan, Travis A. Gerke, Gwo‐Shu Mary Lee, Jian‐Hua Luo, Sreenivasa R. Chinni, Lorelei A. Mucci, Felix Y. Feng, Philip W. Kantoff
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2451-2469 (2022)
Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2
Externí odkaz:
https://doaj.org/article/1e7d977b030b44b383eed28d4cf9959d
Autor:
Martin Sjöström, Emma Niméus, Erik Holmberg, Lena Tran, Axel Stenmark Tullberg, Fredrika Killander, Anikó Kovács, Dan Lundstedt, Per Karlsson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background The implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor
Externí odkaz:
https://doaj.org/article/0736d5bb3c344d828645d3fe5bef9cfb
Autor:
Nicholas R. Rydzewski, Erik Peterson, Joshua M. Lang, Menggang Yu, S. Laura Chang, Martin Sjöström, Hamza Bakhtiar, Gefei Song, Kyle T. Helzer, Matthew L. Bootsma, William S. Chen, Raunak M. Shrestha, Meng Zhang, David A. Quigley, Rahul Aggarwal, Eric J. Small, Daniel R. Wahl, Felix Y. Feng, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, w
Externí odkaz:
https://doaj.org/article/683460200e2546bd8518fb156fad7efa
Autor:
Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics
Externí odkaz:
https://doaj.org/article/fa65632946e846318209a6540b59b6ba
Autor:
Martin Sjöström, Cynthia Veenstra, Erik Holmberg, Per Karlsson, Fredrika Killander, Per Malmström, Emma Niméus, Mårten Fernö, Olle Stål
Publikováno v:
Molecular Oncology, Vol 14, Iss 11, Pp 2713-2726 (2020)
Experimental studies suggest that hepatocyte growth factor (HGF) and its transmembrane tyrosine kinase receptor, Met, in part also relying on Akt kinase activity, mediate radioresistance. We investigated the importance of these biomarkers for the ris
Externí odkaz:
https://doaj.org/article/efd64e9c664e42559b7651d5419d26bc
Autor:
Axel Stenmark Tullberg, Martin Sjöström, Emma Niméus, Fredrika Killander, S. Laura Chang, Felix Y. Feng, Corey W. Speers, Lori J. Pierce, Anikó Kovács, Dan Lundstedt, Erik Holmberg, Per Karlsson
Publikováno v:
Clinical Cancer Research. 29:1783-1793
Purpose: The local immune infiltrate's influence on tumor progression may be closely linked to tumor-intrinsic factors. The study aimed to investigate whether integrating immunologic and tumor-intrinsic factors can identify patients from a low-risk c
Autor:
Anthony DiNatale, Asurayya Worrede, Waleed Iqbal, Michael Marchioli, Allison Toth, Martin Sjöström, Xiaolin Zhu, Eva Corey, Felix Y. Feng, Wanding Zhou, Alessandro Fatatis
Publikováno v:
Cancer Res Commun
We report the inverse association between the expression of androgen receptor (AR) and IL1β in a cohort of patients with metastatic castration-resistant prostate cancer. We also discovered that AR represses the IL1β gene by binding an androgen resp